Abstract
Complexes of platinum tetrachloride with substituted nicotinamides and isonicotinamides were synthesized by the reactions of the corresponding amides with hexachloroplatinic acid. All these complexes are low-toxic. The strong antimetastatic activity of these complexes against Lewis lung carcinoma and B16 melanoma experimental tumors was found in an enzyme system and was then shown in experiments on animals.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1155–1158, June, 2011.
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Fedorov, B.S., Fadeev, M.A., Kozub, G.I. et al. New method for the synthesis of metal complexes based on PtIV and substituted nicotinamides and isonicotinamides and investigation of their antimetastatic activity. Russ Chem Bull 60, 1181–1184 (2011). https://doi.org/10.1007/s11172-011-0186-8
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DOI: https://doi.org/10.1007/s11172-011-0186-8