Abstract
Persulfated derivatives of natural polyhydroxy compounds, such as lignans secoisolariciresinol, and isolariciresinol, flavonoid dihydroquercetin, and myo-inositol, have been synthesized. The ability of these compounds to inhibit the intrinsic pathway of blood coagulation (APTT-test) and to reduce the activity of coagulation factor Xa in the presence of antithrombin(III) has been studied.
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References
I. Melnikova, Nature Reviews Drug Discovery, 2009, 8, 353.
V. V. Kakkar, S. Kakkar, R. M. Sanderson, C. E. Peers, Haemostasis, 1986, 16, 19.
J. Fareed, D. A. Hoppensteadt, R. L. Bick, Sem. Thromb. Hemost., 2000, 26, 5.
D. Mukherjee, E. G. Topol, Prog. Cardiovasc. Dis., 2002, 45, 139.
A. G. Turpie, Sem. Thromb. Hemost., 2002, 28, 3.
P. A. S. Mourao, Curr. Pharm. Des., 2004, 10, 967.
M. Guerrini, D. Beccati, Z. Shriver, A. Naggi, K. Viswanathan, A. Bisio, I. Capila, J. C. Lansing, S. Guglieri, B. Fraser, A. Al-Hakim, N. S. Gunay, Z. Zhang, L. Robinson, L. Buhse, M. Nasr, J. Woodcock, R. Langer, G. Venkataraman, R. J. Linhardt, B. Casu, G. Torri, R. Sasisekharan, Nat. Biotechnol., 2008, 26, 669.
D. J. Tyrrel, A. P. Horne, K. R. Holme, J. M. H. Preuss, C. P. Page, Adv. Pharmacol., 1999, 46, 151.
A. Nardella, F. Chaubet, C. Boisson-Vidal, C. Blondin, P. Durand, J. Jozefonvicz, Carbohydr. Res., 1996, 289, 201.
V. H. Pomin, M. S. Pereira, A. P. Valente, D. M. Tollefsen, M. S. G. Pavro, P. A. Mourro, Glycobiology, 2005, 15, 369.
A. Cumashi, N. A. Ushakova, M. E. Preobrazhenskaya, A. D’Incecco, A. Piccoli, L. Totani, N. Tinari, G. E. Morozevich, A. E. Berman, M. I. Bilan, A. I. Usov, N. E. Ustyuzhanina, A. A. Grachev, C. J. Sanderson, M. Kelly, G. A. Rabinovich, S. Iacobelli, N. E. Nifantiev, Glycobiology, 2007, 17, 541.
P. Sinaÿ, J. C. Jacquinet, M. Petitou, P. Duchaussoy, I. Lederman, J. Choay, G. Torri, Carbohydr. Res., 1984, 132, C5.
M. Petitou, P. Duchaussoy, I. Lederman, J. Choay, P. Sinas, J. C. Jacquinet, G. Torri, Carbohydr. Res., 1986, 147, 221.
C. A. A. van Boeckel, M. Petitou, Angew. Chem., Int. Ed., 1993, 32, 1671.
M. Petitou, C. A. A. van Boeckel, Angew. Chem., Int. Ed., 2004, 43, 3118.
D. Montaigne, X. Marechal, S. Lancel, B. Decoster, P. Asseman, R. Neviere, Thromb Haemost., 2008, 100, 912.
S. K. Nadar, D. Goyal, E. Shantsila, P. Banerjee, G. Y. Lip, Expert Rev. Cardiovasc. Ther., 2009, 7, 577.
B. H. Monien, B. L. Henry, A. Raghuraman, M. Hindle, U. R. Desai, Bioorg. Med. Chem., 2006, 14, 7988.
G. T. Gunarsson, U. R. Desai, Bioorg. Med. Chem. Lett., 2003, 13, 679.
M. E. Sousa, M. Correia da Silva, M. M. M. Pinto, in Natural Products: Chemistry, Biochemistry and Pharmacology, Ed. G. Brahmachari, Narosa Publishing House PVT. Ltd., New Delhi, India ISBN: 978-81-7319-886-1, 2009.
V. B. Krylov, N. E. Ustyuzhanina, A. A. Grachev, N. E. Nifantiev, Tetrahedron Lett., 2008, 49, 5877.
N. E. Nifantiev, D. V. Yashunsky, V. M. Menshov, Yu. E. Tsvetkov, D. E. Tsvetkov, A method for isolation of secoisola-riciresinol and dihydroquercetin from the pulp (versions), Application for the Patent of the Russian Federation and PCT PCT/RU2008/000176, 26.03.2008.
A. J. Fatiadi, Carbohydr. Res., 1970, 12, 293.
N. Takahashi, F. Egami, Nippon Kagaku Zasshi, 1959, 80, 1364.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 228–231, January, 2010.
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Krylov, V.B., Ushakova, N.A., Ustyuzhanina, N.E. et al. Study of sulfated derivatives of polyhydroxy compounds as inhibitors of blood coagulation. Russ Chem Bull 59, 232–235 (2010). https://doi.org/10.1007/s11172-010-0067-6
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DOI: https://doi.org/10.1007/s11172-010-0067-6