Abstract
Structure-activity relationships for ligands of the colchicine site of tubulin were analyzed based on their common pharmacophore. The role of the elucidation of the three-dimensional structure of the colchicine site of tubulin on the development of studies aimed at the search for the ligands of this site is analyzed.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 655–662, April, 2007.
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Zefirova, O.N., Diikov, A.G., Zyk, N.V. et al. Ligands of the colchicine site of tubulin: A common pharmacophore and new structural classes. Russ Chem Bull 56, 680–688 (2007). https://doi.org/10.1007/s11172-007-0106-0
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DOI: https://doi.org/10.1007/s11172-007-0106-0