Abstract
Electrochemically induced catalytic multicomponent transformation of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized pyrano[2,3-c]pyrazole system in 78–99} yields. The developed efficient electrocatalytic approach to medicinally relevant spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazoles] is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a novel example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reaction strategy.
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Elinson, M.N., Dorofeev, A.S., Miloserdov, F.M. et al. Electrocatalytic multicomponent assembling of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile: facile and convenient way to functionalized spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazole] system. Mol Divers 13, 47–52 (2009). https://doi.org/10.1007/s11030-008-9100-1
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DOI: https://doi.org/10.1007/s11030-008-9100-1