Summary
[11C]-choline has been reported as a potential tracer for imaging a variety of human tumors with positron emission tomography (PET). A new labeling technique for [11C]-choline was established depending on parameters optimized, such as reaction time, volume, temperature, and the quantity of DMAE.The synthesis yield was improved from 82.0% to 96.5% (EOB), while the consumption of DMAE precursor decreased from 60 to 2 mg. Absolute yield of [11C]-choline was 2500 MBq for a 10-minute irradiation at15mA, and a total synthesis time of less than 8 minutes from [11C]-CH3I to [11C]-choline.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jinming, Z., Jiahe, T., Wushang, W. et al. A new technique for labeling of [11C]-choline, a positron-emitting tracer for tumor imaging. J Radioanal Nucl Chem 267, 665–668 (2006). https://doi.org/10.1007/s10967-006-0100-2
Issue Date:
DOI: https://doi.org/10.1007/s10967-006-0100-2