Abstract
Bovine-derived biological apatite has a long history for use in human health care as bone substitute. This article reports an elegant method of designing bovine-derived hydroxyapatite (BHA) blocks suitable for drug delivery. Neomycin sulphate (NS) was selected as a model drug and its loading and release studies were performed under in-vitro physiological conditions. The results indicate that phase purity and structural integrity of the BHA are retained even after entrapment of drug molecules. It was noticed that the rate of neomycin delivery was directly proportional to the porosity of the BHA blocks. The in-vitro release studies suggest that BHA may be used as a good carrier system for neomycin delivery.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
D. I. C. KIRKPATRICK, J. A. VON FRAUNHOFER, L. S. TRACHTENBERG, D. SELIGSON and P. D. MANGINO, Orthopedics 8 (1985) 1130.
T. IPSEN, P. S. JORGENSON, V. DAMHOLT and C. TORHOLM, Acta. Orthop. Scand. 62 (1991) 592.
G. WEI, Y. KOTOURA, M. OKA, T. YAMAMURO, R. WADA, S. H. HYON and Y. IKADA, J. Bone Joint Surg. [Br] 73-B (1991) 246.
R. MURUGAN, T. S. S. KUMAR and K. P. RAO, Mater. Lett. 57 (2002) 429.
R. MURUGAN, K. P. RAO and T. S. S. KUMAR, Bull. Mater. Sci. 26 (2003) 523.
R. MURUGAN and S. RAMAKRISHNA, J. Appl. Biomater. Biomech. 3 (2005) 93.
C. CHAI and B. B. NISSAN, Inter. Ceramic Monographs 1 (1994) 79.
G. JIANG and D. SHI, J. Biomed. Mater. Res. (Appl. Biomater.). 43 (1999) 117.
I. SUNSHINE, “Handbook of Spectrophotometric Data of Drugs” (CRC Press, Boca Raton, 1980).
Powder Diffraction File (inorganic phases), File No. 9-432, International Centre for Diffraction Data, Newton Square, PA.
J. C. MERRY, I. R. GIBSON, S. M. BEST and W. BONFIELD, J. Mater. Sci. Mater. Med. 9 (1998) 779.
W. R. WALSH, D. P. LABRADOR, H. D. KIM and N. GUZELSU, Ann. Biomed. Engng. 22 (1994) 404.
J. C. LE HUEC, T. SCHAEVERBEKE, D. CLEMENT, J. FABER and A. LE RABELLER, Biomaterials 16 (1995) 113.
T. M. KEAVENY and W. C. HAYES, J. Biomech. Engng. 115 (1993) 534.
C. E. RAWLINGS III and R. H. WILKINS, in “Neurosurgery Update I. Diagnosis, Operative Technique and Neuro-Oncology”, edited by R. H. Wilkins and S. S. Rengachary, (McGraw Hill, New York, 1990).
H. W. BUCHHOLZ, R. A. ELSON, H. ENGELBRECHT, H. LODENKAMPER, J. ROTTGER and A. SIEGEL, J. Bone Joint Surg. [Br] 63-B (1991) 342.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Murugan, R., Ramakrishna, S. Designing biological apatite suitable for neomycin delivery. J Mater Sci 41, 4343–4347 (2006). https://doi.org/10.1007/s10853-006-6157-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10853-006-6157-z