Mice selected for high score in the extrapolation test (EX line) and kept under conditions of “enriched environment” for 3 months demonstrated changes in locomotor and exploratory activity and enhanced reaction to novelty. The relative brain weight was higher and neurogenesis in the hippocampal fascia dentate was more intensive in this group. In non-selected mice, the changes were similar, but insignificant in many cases.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Golibrodo VA, Perepelkina OV, Lil’p IG, Poletaeva II. The behavior of mice selected for cognitive signs in the test for hyponeophagy. Zh. Vyssh. Nervn. Deyat. 2014;64(6):639. Russian.
Perepelkina OV, Golibrodo VA, Lilp IG, Poletaeva II. Selection of mice for high scores of elementary logical task solution. Dokl. Biol. Sci. 2015;460(1):52-56.
Perepelkina OV, Markina NV, Poletaeva II. The Ability to Extrapolate the Direction of Movement in Mice Selected for Large and Small Brain Weight: The Influence of Environmental Enrichment. Zh. Vyssh. Nervn. Deyat. 2006;56(2):282-286. Russian.
Timoshenko TV, Poletaeva II, Pavlova GV, Revishchin AV. Effect of neonatal injections of the neuropeptide Semax on cell proliferation in hippocampal dentate area in rats of two genotypes. Dokl. Biol. Sci. 2009;424(1):78-80.
Fuss J, Ben Abdallah NM, Vogt MA, Touma C, Pacifici PG, Palme R, Witzemann V, Hellweg R, Gass P. Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus. 2010;20(3):364-376.
Goes TC, Antunes FD, Teixeira-Silva F. Environmental enrichment for adult rats: effects on trait and state anxiety. Neurosci. Lett. 2015;584:93-96.
Kempermann G, Gast D, Gage FH. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol. 2002;52(2):135-143.
Poletaeva II, Zorina ZA. A genetic approach to the study of simple cognitive abilities in animals. Russ. J. Cogn. Sci. 2014;1(3):31-55.
Rogers J, Vo U, Buret LS, Pang TY, Meiklejohn H, Zeleznikow-Johnston A, Churilov L, van den Buuse M, Hannan AJ, Renoir T. Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment. Transl. Psychiatry. 2016;6:e794. doi: https://doi.org/10.1038/tp.2016.52.
Tsai PP, Pachowsky U, Stelzer HD, Hackbarth H. Impact of environmental enrichment in mice. 1: effect of housing conditions on body weight, organ weights and haematology in different strains. Lab. Anim. 2002;36(4):411-419.
van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 1999;2(3):266-270.
Zeleznikow-Johnston A, Burrows EL, Renoir T, Hannan AJ. Environmental enrichment enhances cognitive flexibility in C57BL/6 mice on a touch screen reversal learning task. Neuropharmacology. 2017;117:219-226.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 11, pp. 532-535, November, 2017
Rights and permissions
About this article
Cite this article
Tarasova, A.Y., Perepelkina, O.V., Lil’p, I.G. et al. Influence of “Enriched Environment” on Behavior and Neurogenesis in Mice Selected by Cognitive Trait. Bull Exp Biol Med 164, 583–586 (2018). https://doi.org/10.1007/s10517-018-4036-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-018-4036-7