We studied the effect of intracerebral transplantation of bone marrow mesenchymal stem cells on microcirculation (density of microvascular network and reactivity of arterioles) in the pia mater of 2-3-month-old rats. It was found that after transplantation of mesenchymal stem cells, the density of pial microcirculatory network in the contralateral hemisphere significantly increased (by 1.7 times; p<0.05) in comparison with both intact animals and controls. The number of arterioles in the studied area increased most markedly (by ~2.5 times; p<0.05) in comparison with other groups. Intracerebral transplantation of mesenchymal stem cells or conditioned culture medium (α-MEM) had no effect on reactivity of pial arterioles.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 16-20, January, 2013
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Sokolova, I.B., Sergeev, I.V., Bilibina, A.A. et al. Effect of Intracerebral Transplantation of Mesenchymal Stem Cells on Pial Microcirculation in Rats. Bull Exp Biol Med 155, 134–138 (2013). https://doi.org/10.1007/s10517-013-2098-0
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DOI: https://doi.org/10.1007/s10517-013-2098-0