The effects of T-31, AB-17, and AB-9 peptides on old (passage 8) thymocyte culture were studied. Only AB-9 peptide exhibited a complex geroprotective effect on thymocytes during their aging. Peptide AB-9 stimulated proliferative activity and differentiation of thymocytes and inhibited their apoptosis.
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I. M. Kvetnoy, A. A. Yarilin, V. O. Polyakova, and I. V. Knyaz’kin, Neuroimmunoendocrinology of the Thymus [in Russian], St. Petersburg (2005).
V. O. Polyakova and I. M. Kvetnoy, The Thymus and Aging (Neuroimmunoendocrinological Mechanisms) [in Russian], St. Petersburg (2004).
V. Kh. Khavinson and V. G. Morozov, Pineal and Thymic Peptides and Regulation of Aging [in Russian], St. Petersburg (2001).
V. Kh. Khavinson, E. G. Rybakina, and V. V. Malinin, Byull. Eksp. Biol. Med., 133, No. 5, 574–577 (2002).
G. Anderson, B. C. Harman, K. J. Hare, and E. J. Jenkinson, Semin. Immunol., 12, No. 5, 457–464 (2000).
M. Pinti, M. Nasi, E. Lugli, et al., Curr. Pharm. Res., 16, No. 6, 597–603 (2010).
T. Yamamoto, S. Morita, R. Go, et al., Int. J. Radiat. Oncol. Biol. Phys., 77, No. 1, 235–243 (2010).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 2, pp. 203–206, February, 2011
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Lin’kova, N.S., Polyakova, V.O., Trofimov, A.V. et al. Peptidergic Regulation of Thymocyte Differentiation, Proliferation, and Apoptosis during Aging of the Thymus. Bull Exp Biol Med 151, 239–242 (2011). https://doi.org/10.1007/s10517-011-1298-8
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DOI: https://doi.org/10.1007/s10517-011-1298-8