New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10−9 M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H2O2 and glutamate. GK-2 in a concentration of 10−8 M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 537–540, November, 2010
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Antipova, T.A., Gudasheva, T.A. & Seredenin, S.B. In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic. Bull Exp Biol Med 150, 607–609 (2011). https://doi.org/10.1007/s10517-011-1202-6
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DOI: https://doi.org/10.1007/s10517-011-1202-6