Abstract
Aβ-2M-amyloidosis is a type of systemic amyloidosis that is specifically seen in patients with chronic kidney diseases. The precursor protein of Aβ-2M-amyloid fibril is β2-microglobulin, and its elevated serum level is the main cause of Aβ-2M-amyloidosis in patients with kidney failure. However, the precise mechanism of Aβ-2M-amyloidogenesis remains unclear. In vitro analyses of Aβ-2M amyloidogenesis are still being actively conducted. Osteolytic lesions are often found around synovial membrane with Aβ-2M-amyloid deposition. Both evident osteoclastogenesis and active osteoclastic bone resorption are found, while osteoblastic bone formation is absent in the lesion most likely associated with the inflammation caused by infiltrating macrophages/monocytes into Aβ-2M-amyloid deposition. The precise cell biological mechanism of this inflammatory change is unknown. Further studies are needed to establish specific treatments against this as yet unsolved problem with long-term dialysis therapy.
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Kazama, J., Yamamoto, S., Takahashi, N. et al. Aβ-2M-amyloidosis and related bone diseases. J Bone Miner Metab 24, 182–184 (2006). https://doi.org/10.1007/s00774-005-0669-5
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DOI: https://doi.org/10.1007/s00774-005-0669-5