Summary.
S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals.
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Mannick, J. Regulation of apoptosis by protein S-nitrosylation. Amino Acids 32, 523–526 (2007). https://doi.org/10.1007/s00726-006-0427-6
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DOI: https://doi.org/10.1007/s00726-006-0427-6