Summary
Choroid plexus papillomas (CPP) are rare intracranial tumours with a favourable long-term outcome after surgical excision. Although they are histologically benign, local recurrences may occasionally occur, but leptomeningeal dissemination is exceptional. We report an unusual example of a fourth ventricle choroid plexus papilloma with diffuse leptomeningeal seeding. Neither the initial tumour nor the recurrence showed malignant histological features. Treatment with systemic and intrathecal chemotherapy was ineffective in this patient. We review the literature concerning leptomeningeal dissemintation of benign choroid plexus papillomas.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
A Aguzzi S Brandner W Paulus (2000) Choroid plexus tumours P Kleihues WK Cavenee (Eds) World Health Organization classification of tumours SeriesTitlePathology and genetics: tumours of the nervous system IARC Press Lyon 84–86
M Arico E Raiteri G Bossi MT Giordana F Corbella D Locatelli S Pezzota (1994) ArticleTitleChoroid plexus carcinoma: report of one case with favourable response to treatment Med Pediatr Oncol 22 274–278 Occurrence Handle8107660 Occurrence Handle10.1002/mpo.2950220412 Occurrence Handle1:STN:280:DyaK2c7ltVCitQ%3D%3D
C Berger P Thiesse A Lellouch-Tubiana C Kalifa A Pierre-Kahn E Bouffet (1998) ArticleTitleChoroid plexus carcinomas in childhood: clinical features and prognostic factors Neurosurgery 42 470–475 Occurrence Handle9526979 Occurrence Handle10.1097/00006123-199803000-00006 Occurrence Handle1:STN:280:DyaK1c7os1Wktw%3D%3D
PC Burger B Scheitahuer (1993) Tumours of the central nervous system SeriesTitleAtlas of tumour pathology Armed Forces Institute of Pathology Washington, DC 394–404
E Chow JJ Jenkins PC Burger DA Reardon JW Langston RA Sanford RL Heideman LE Kun TE Merchant (1999) ArticleTitleMalignant evolution of choroid plexus papillomas Pediatr Neurosurg 31 127–130 Occurrence Handle10708353 Occurrence Handle10.1159/000028847 Occurrence Handle1:STN:280:DC%2BD3c7ntVKntQ%3D%3D
RC Domingues JM Taveras P Reimer BR Rosen (1991) ArticleTitleForamen magnum choroid plexus papilloma with drop metastases to the lumbar spine Am J Neuroradiol 12 564–565 Occurrence Handle2058519 Occurrence Handle1:STN:280:DyaK3M3otFKgtA%3D%3D
PK Duffner LE Kun PC Burger ME Horowitz RA Sanford JP Krisher RK Mulhern HE James HL Rekate HS Friedman (1995) ArticleTitlePostoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas Pediatr Neurosurg 22 189–196 Occurrence Handle7619719 Occurrence Handle1:STN:280:DyaK2MzksV2rsA%3D%3D
RG Ellenbogen KR Winston WJ Kupsky (1989) ArticleTitleTumors of the choroid plexus in children Neurosurgery 25 327–335 Occurrence Handle2771002 Occurrence Handle10.1097/00006123-198909000-00001 Occurrence Handle1:STN:280:DyaL1MzmsFCrtQ%3D%3D
H Enomoto M Mizuno T Katsumata T Doi (1991) ArticleTitleIntracranial metastasis of a choroid plexus papilloma originating in the cerebellopontine angle region: a case report Surg Neurol 36 54–58 Occurrence Handle2053075 Occurrence Handle10.1016/0090-3019(91)90134-U Occurrence Handle1:STN:280:DyaK3M3nt1WltQ%3D%3D
A Fiorillo G Maggi S Cirillo R Migliorati F Buffardi E Alfieri MS Sabbatino A D’Amico ML DelBasso DeCaro (2003) ArticleTitleEfficacy of sequential chemotherapy including methotrexate and doxorubicin in an infant with partially resected choroid plexus carcinoma Pediatr Neurosurg 38 21–26 Occurrence Handle12476023 Occurrence Handle10.1159/000067559
A Gianella-Borradori PM Zeltzer B Bodey M Nelson H Britton A Marlin (1992) ArticleTitleChoroid plexus tumours in childhood. Response to chemotherapy, and immunophenotypic profile using a panel of monoclonal antibodies Cancer 69 809–816 Occurrence Handle1370394 Occurrence Handle10.1002/1097-0142(19920201)69:3<809::AID-CNCR2820690333>3.0.CO;2-Q Occurrence Handle1:STN:280:DyaK387htVOnsw%3D%3D
C Girardot M Boukobza JP Lamoureux JP Sichez L Capelle A Zouaoui B Bencherif J Metzger (1990) ArticleTitleChoroid plexus papillomas of the posterior fossa in adults: MR imaging and gadolinium enhancement J Neuroradiol 17 303–318 Occurrence Handle2092089 Occurrence Handle1:STN:280:DyaK3M3isFOrtg%3D%3D
B Guidetti A Spallone (1981) ArticleTitleThe surgical treatment of choroid plexus papillomas. Results of 27 years experience Neurosurg Rev 4 129–137 Occurrence Handle7301142 Occurrence Handle10.1007/BF01743638 Occurrence Handle1:STN:280:DyaL38%2FlvVGgtg%3D%3D
F Gullotta AS de Melo (1979) ArticleTitleDas Karzinom des plexus choroideus. Klinische lichtmikroskopische und elektronenoptische Untersuchungen Neurochirurgia 22 1–9 Occurrence Handle759977 Occurrence Handle1:STN:280:DyaE1M%2FpsVWjug%3D%3D
M Irsutti M Thorn-Kany P Arrue J Richaud JC Sol MB Delisle C Manelfe (2000) ArticleTitleSuprasellar seeding of a benign choroid plexus papilloma of the fourth ventricle with local recurrence Neuroradiology 42 657–661 Occurrence Handle11071438 Occurrence Handle10.1007/s002340000370 Occurrence Handle1:STN:280:DC%2BD3MzgsVCmtQ%3D%3D
J Jagielski M Zabek T Wierzba-Bobrowicz B Takomiec SJ Chrapusta (2001) ArticleTitleDisseminating histologically benign multiple papilloma of the choroid plexus: case report Folia Neuropathol 39 209–213 Occurrence Handle11770132 Occurrence Handle1:STN:280:DC%2BD38%2Fkt1Gkuw%3D%3D
R Leblanc S Bekhor D Melanson S Carpenter (1998) ArticleTitleDiffuse craniospinal seeding from a benign fourth ventricle choroid plexus papilloma: case report J Neurosurg 88 757–760 Occurrence Handle9525724 Occurrence Handle1:STN:280:DyaK1c7osVKgtQ%3D%3D
ML Levy A Goldfarb DJ Hyder I Gonzales-Gomez M Nelson FH Gilles JG McComb (2001) ArticleTitleChoroid plexus tumours in children: significance of stromal invasion Neurosurgery 48 303–309 Occurrence Handle11220372 Occurrence Handle10.1097/00006123-200102000-00010 Occurrence Handle1:STN:280:DC%2BD3M3ksVCrtA%3D%3D
P Lewis (1967) ArticleTitleCarcinoma of the choroid plexus Brain 90 177–186 Occurrence Handle6023072 Occurrence Handle10.1093/brain/90.1.177 Occurrence Handle1:STN:280:DyaF2s7jsVOlsg%3D%3D
D Leys F Pasquier JP Lejeune F Lesoin H Petit JM Delandsheer (1986) ArticleTitlePapillome bénin des plexus choroïdes. Deux récidives locales et essaimage intraventriculaire Neurochirurgie 32 258–261 Occurrence Handle3762840 Occurrence Handle1:STN:280:DyaL2s%2FhsFSrsQ%3D%3D
BL Maria ML Graham LC Strauss MD Wharam (1985) ArticleTitleResponse of a recurrent choroid plexus tumour to combination chemotherapy J Neurooncol 3 259–262 Occurrence Handle2414413 Occurrence Handle10.1007/BF00165187 Occurrence Handle1:STN:280:DyaL28%2Fjs1ersw%3D%3D
T Masuzawa H Shimabukuro N Yoshimizu F Sato (1981) ArticleTitleUltrastructure of disseminated choroid plexus papilloma Acta Neuropathol (Berl) 54 321–324 Occurrence Handle10.1007/BF00697007 Occurrence Handle1:STN:280:DyaL3M3nvVCgsw%3D%3D
DD Matson FDL Crofton (1960) ArticleTitlePapilloma of the choroid plexus in childhood J Neurosurg 17 1002–1027 Occurrence Handle13768200 Occurrence Handle1:STN:280:DyaF3c%2FovVajug%3D%3D
T McCall M Binning DT Blumenthal RL Jensen (2006) ArticleTitleVariations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature Surg Neurol 66 62–67 Occurrence Handle16793445 Occurrence Handle10.1016/j.surneu.2005.09.023
AW McEvoy M Galloway T Revesz ND Kitchen (2002) ArticleTitleMetastatic choroid plexus papilloma: a case report J Neurooncol 56 241–246 Occurrence Handle12061730 Occurrence Handle10.1023/A:1015044012574
RE McLendon DS Enterline (1998) Tumors of specialized tissues of central neuroepithelial origin DD Bigner RE McLendon JM Bruner (Eds) Russell & Rubinstein’s SeriesTitlePathology of tumours of the nervous system NumberInSeries2 Arnold London 37–65
S Niikawa T Ito T Murakawa H Hirayama T Ando N Sakai H Yamada (1993) ArticleTitleRecurrence of choroid plexus papilloma with malignant transformation: case report and lectin histochemistry study Neurol Med Chir (Tokyo) 33 32–35 Occurrence Handle1:STN:280:DyaK3s7ps1OksQ%3D%3D Occurrence Handle10.2176/nmc.33.32
RJ Packer G Perilongo D Johnson LN Sutton G Vezina RA Zimmerman J Ryan G Reaman L Schut (1992) ArticleTitleChoroid plexus carcinoma of childhood Cancer 69 580–585 Occurrence Handle1728390 Occurrence Handle10.1002/1097-0142(19920115)69:2<580::AID-CNCR2820690250>3.0.CO;2-O Occurrence Handle1:STN:280:DyaK38%2FpslSjsg%3D%3D
W Paulus W Jänisch (1990) ArticleTitleClinicopathological correlations in epithelial choroid plexus neoplasms: a study of 52 cases Acta Neuropathol 80 635–641 Occurrence Handle1703384 Occurrence Handle10.1007/BF00307632 Occurrence Handle1:STN:280:DyaK3M7ht1ensg%3D%3D
P Pencalet C Sainte-Rose A Lellouch-Tubiana C Kalifa F Brunelle S Sgouros P Meyer G Cinalli M Zerah A Pierre-Kahn D Renier (1998) ArticleTitlePapillomas and carcinomas of the choroid plexus in children J Neurosurg 88 521–528 Occurrence Handle9488307 Occurrence Handle1:STN:280:DyaK1c7kslKgsw%3D%3D Occurrence Handle10.3171/jns.1998.88.3.0521
JY Pierga C Kalifa MJ Terrier-Lacombe JL Habrand J Lemerele (1993) ArticleTitleCarcinoma of the choroid plexus: a paediatric experience Med Pediatr Oncol 21 480–487 Occurrence Handle8341215 Occurrence Handle10.1002/mpo.2950210705 Occurrence Handle1:STN:280:DyaK3szktFCjsw%3D%3D
RL Rovit MM Schechter P Chodroff (1970) ArticleTitleChoroid plexus papillomas. Observations on radiographic diagnosis Am J Roentgenol Radium Ther Nucle Med 110 608–617 Occurrence Handle1:STN:280:DyaE3M%2FmtlyqtA%3D%3D
DS Russell LJ Rubinstein (1989) Papillomas and carcinomas of the choroid plexus SeriesTitlePathology of tumours of the nervous system Arnold London 394–404
TP Shakespeare MM Slancar AR Mallik DR Bell (1997) ArticleTitleCSF dissemination of a benign choroid plexus papilloma Aust NZ J Med 27 597–598 Occurrence Handle1:STN:280:DyaK1c%2FmvVCjtQ%3D%3D
N Shirakawa S Kannuki K Matsumoto (1994) ArticleTitleClinicopathological study on choroid plexus tumors: immunohistochemical features and argyrophilic nucleolar organizer regions values (Abstract) Noshuyo Byori 11 99–105 Occurrence Handle8162158 Occurrence Handle1:STN:280:DyaK2c3hsVKgsg%3D%3D
A Talacchi E De Micheli C Lombardo S Turazzi A Bricolo (1999) ArticleTitleChoroid plexus papillomas of the cerebellopontine angle: a twelve patient series Surg Neurol 51 621–629 Occurrence Handle10369230 Occurrence Handle10.1016/S0090-3019(99)00024-5 Occurrence Handle1:STN:280:DyaK1M3psF2jtg%3D%3D
J Valencak W Dietrich M Raderer K Dieckmann D Prayer JA Hainfellner C Marosi (2000) ArticleTitleEvidence of therapeutic efficacy of CCNU in recurrent choroid plexus papillomas J Neurooncol 49 263–268 Occurrence Handle11212906 Occurrence Handle10.1023/A:1006405106553 Occurrence Handle1:STN:280:DC%2BD3M7nvF2isw%3D%3D
Z Varga I Vajtai (1998) ArticleTitlePrognostic markers in the histopathological diagnosis of tumors of the choroid plexus (Abstract) Orv Hetil 139 761–765 Occurrence Handle9578705 Occurrence Handle1:STN:280:DyaK1c3jvFymsQ%3D%3D
JE Wolff M Sajedi R Brant MJ Coppes RM Egeler (2002) ArticleTitleChoroid plexus tumours Br J Cancer 87 1086–1091 Occurrence Handle12402146 Occurrence Handle10.1038/sj.bjc.6600609 Occurrence Handle1:STN:280:DC%2BD38nkt1artA%3D%3D
WL Wolfson WJ Brown (1977) ArticleTitleDisseminated choroid plexus papilloma. An ultrastructural study Arch Pathol Lab Med 101 366–368 Occurrence Handle577391 Occurrence Handle1:STN:280:DyaE2s3gtV2itA%3D%3D
H Yu TL Yao J Spooner JR Stumph R Hester PE Konrad (2006) ArticleTitleDelayed occurrence of multiple spinal drop metastases from a posterior fossa Choroid plexus papilloma: case report J Neurosurg Spine 4 494–496 Occurrence Handle16776361
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ortega-Martínez, M., Cabezudo-Artero, J., Fernández-Portales, I. et al. Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien) 149, 1229–1237 (2007). https://doi.org/10.1007/s00701-007-1292-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-007-1292-0