Abstract
We have analyzed muscle biopsy specimens from polymyositis patients who are also positive for human T cell lymphotropic virus type I (HTLV-I) using both immunohistochemistry for surface antigens of lymphocytes and macrophages and in situ polymerase chain reaction for HTLV-I proviral DNA on the same sections. We found HTLV-I in CD4+ cells but not in macrophages. This finding suggests that most of the HTLV-I-containing CD4+ cells are not macrophages but lymphocytes.
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Received: 12 February 1996 / Revised, accepted: 11 April 1996
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Higuchi, I., Hashimoto, K., Matsuoka, E. et al. The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4+ lymphocytes. Acta Neuropathol 92, 358–361 (1996). https://doi.org/10.1007/s004010050530
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DOI: https://doi.org/10.1007/s004010050530