Abstract
Objectives
To study the effect of patient size, body region and modulation strength on tube current and image quality on CT examinations that use automatic tube current modulation (ATCM).
Methods
Ten physical anthropomorphic phantoms that simulate an individual as neonate, 1-, 5-, 10-year-old and adult at various body habitus were employed. CT acquisition of head, neck, thorax and abdomen/pelvis was performed with ATCM activated at weak, average and strong modulation strength. The mean modulated mAs (mAsmod) values were recorded. Image noise was measured at selected anatomical sites.
Results
The mAsmod recorded for neonate compared to 10-year-old increased by 30 %, 14 %, 6 % and 53 % for head, neck, thorax and abdomen/pelvis, respectively, (P < 0.05). The mAsmod was lower than the preselected mAs with the exception of the 10-year-old phantom. In paediatric and adult phantoms, the mAsmod ranged from 44 and 53 for weak to 117 and 93 for strong modulation strength, respectively. At the same exposure parameters image noise increased with body size (P < 0.05).
Conclusions
The ATCM system studied here may affect dose differently for different patient habitus. Dose may decrease for overweight adults but increase for children older than 5 years old. Care should be taken when implementing ATCM protocols to ensure that image quality is maintained.
Key Points
• ATCM efficiency is related to the size of the patient’s body.
• ATCM should be activated without caution in overweight adult individuals.
• ATCM may increase radiation dose in children older than 5 years old.
• ATCM efficiency depends on the protocol selected for a specific anatomical region.
• Modulation strength may be appropriately tuned to enhance ATCM efficiency.
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
Introduction
Automatic tube current modulation (ATCM) systems adapt the tube current on the basis of each patient’s attenuation characteristics and aim to generate images of diagnostic quality at the lowest possible radiation dose. Previous studies have reported that ATCM systems can reduce patient radiation dose by up to 60 % compared to the fixed tube current examinations [1–5]. However, the degree of radiation dose reduction is strongly influenced by the patient’s size and the anatomy of the imaged body volume. The pattern of tube current modulation is determined by a certain image quality metric, which is different between ATCM schemes. This image quality metric is specified in the form of either image noise or a reference mAs value [6–8]. The level of this metric is selected by the user on the patient size and anatomic region being examined, while in paediatric patients it is selected also depending on the age of the examined individual.
The ATCM system implemented by Siemens Medical Solutions (CARE Dose 4D, Siemens, Erlangen, Germany) adapts the tube current through two parameters recommended for each different body region, but is still operator-defined in terms of (i) the quality reference milliampere-second value (mAsQR), and (ii) the modulation strength setting i.e. weak, average or strong [9, 10]. To achieve exposure optimization, operators must tailor the mAsQR and modulation strength for each region to be examined and patient size. This, however, requires an astute understanding of how the above parameters influence resulting image quality and patient radiation dose. Despite the fact that several studies have been published on the dose reduction from ATCM systems, there is no published data on the effect of patient size and modulation strength on tube current and image quality [11, 12]. Thus, the effectiveness of ATCM during examinations performed on overweight patients is not known. Moreover, the impact of altering the ATCM modulation strength setting on radiation dose and image quality in patients of varying size is not known.
The aim of the present study was to examine systematically the effect of patient size, patient anatomy and prescribed modulation strength on tube current and image quality in CT examinations that use ATCM.
Materials and methods
Anthropomorphic phantoms
Four physical anthropomorphic phantoms (ATOM Phantoms, CIRS, Norfolk, Virginia, USA) that represent the average individual as neonate, 1-year-old, 5-year-old, 10-year-old child and the Rando phantom (Alderson Research Labs, Stanford, CA, USA) that simulates the average adult individual were employed. A whole body lateral scout view of each phantom is shown in Fig. 1.
To simulate patients with increased body size, the phantoms were appropriately modified into different body habitus using bolus material. Bolus is made of a homogeneous, tissue-equivalent gel with a density 1.03 g/cm3 (CIVCO Medical Solutions, Iowa, USA). The bolus material is formed in rectangular sheets, 35 cm × 35 cm, and can be cut to any shape with scissors. The thickness of the bolus sheet was 2 cm.
One bolus (Fig. 1e) and two bolus sheets (Fig. 1f) were placed around the anterior surface of the abdomen and pelvis slabs of the 10-year-old phantom. The aforementioned bolus sheets were cut into 30 cm × 30 cm squares and covered the phantom slabs numbered from 19 to 31. These phantom configurations allow the simulation of a 10-year-old child at three different body sizes, i.e. normal weight and overweight at two different habitus. The 10-year-old phantom in the last two body habitus is designated hereafter as 10-year-old (I) and 10-year-old (II). One bolus sheet 2 cm thick (Fig. 1h) was placed around the anterior surface of the abdomen and pelvis slabs of the adult phantom. This bolus sheet was 35 cm × 35 cm and covered the phantom slabs numbered from 15 to 32. The phantom configured in this body habitus is designated hereafter as adult (I). Two bolus sheets were additionally added, resulting in a total bolus thickness of 6 cm (Fig. 1i). These bolus sheets covered the adult phantom slabs numbered from 17 to 31. The phantom configured in this body habitus is designated hereafter as adult (II). Finally, two additional bolus sheets were added around the anterior surface of the abdomen and pelvis slabs of the adult phantom (Fig. 1j), resulting in a total bolus thickness of 10 cm. The inferior bolus sheet covered the phantom slabs numbered from 22 to 29, while the superior bolus sheet covered the phantom slabs numbered from 20 to 30. The phantom configured in this body habitus is designated hereafter as adult (III). The above phantom configurations allow the simulation of an adult individual at four different body sizes, i.e. normal weight, and overweight at three different body habitus (I), (II) and (III). Thus, these phantoms exhibit a progressively increasing attenuation of the x-ray beam in the abdominal and pelvic regions.
Weight and height values of each phantom are listed in Table 1. To obtain an index of the body size of each phantom, circumference measurements were performed in specific anatomical sites of each body region. Head circumference was measured at the axial image depicting the maxillary sinuses. Neck circumference was measured at the axial image depicting the fourth cervical vertebrae. Thorax circumference was measured at the axial image depicting the central lung parenchyma. Abdomen circumference was measured at the axial CT image depicting the superior part of the iliac crest.
CT system and ATCM mechanism
A 16-slice CT system (Sensation 16, Siemens, Germany) equipped with the CARE Dose 4D (software version syngo CT 2006G, Siemens, Germany) ATCM system was used. ATCM is accomplished by modulating the tube current both angularly and along the z-axis of the patient according to each patient’s individual anatomy [9–14]. The tube current is modulated according to the difference in the recorded attenuation between the examined individual and an average sized patient, named as the ‘reference patient’. An image quality reference mAs (mAsQR) setting is preselected for the reference patient according to the diagnostic requirements. On the basis of the topogram, the system determines whether the patient’s body size is smaller or larger compared to the reference patient. If the algorithm detects that the examined body part is smaller than the reference patient’s, the system prescribes a decrease in tube current below mAsQR. Similarly, if the algorithm detects that the examined body part is larger compared to the reference patient, the system prescribes an increase in tube current above mAsQR. Hence, when imaging smaller or larger patients compared to the reference patient, images of lower or higher noise levels, respectively, are generated. According to the manufacturer, the reference patient for adult examinations is defined as a typical adult weighing 70 kg. For child examinations, the reference patient is defined as a typical 5-year-old child weighing 20 kg. In the current study, the Rando phantom was considered as the reference patient for the adult examinations and the ATOM phantom simulating the average 5-year-old individual was considered as the reference patient for the paediatric examinations. The ATCM system allows the selection of the modulation strength on the basis of the anatomical characteristics of the examined patient. Prior to the acquisition of the scout view, the operator is allowed to choose the required modulation strength, which will be applied in the examination. Three modulation strength options (weak, average and strong decrease) are available for slim or undersized anatomical regions compared to the reference patient. Additionally, three modulation strength options (weak, average and strong increase) are available for obese or oversized anatomical regions compared to the reference patient. Any of the three modulation strength options for slim anatomical regions may be combined with any of the three modulation strength options for obese anatomical regions, resulting in nine different combinations. Figure 2 demonstrates the theoretical effect of the CARE Dose4D system on tube current and image noise [9]. For the slim, strong decrease setting, the tube current is decreased less than constant noise would require. For the obese, strong increase setting, the tube current is increased less than constant noise would require.
CT imaging protocols
To assess the effect of the ATCM in different anatomical regions on tube current and image noise, head, neck, thorax and abdomen/pelvis CT acquisitions were performed using the routine examination protocols specified for children (Table 2). These CT acquisitions were also performed using the routine examination protocols specified for adults (Table 3) to assess the effect of patient target group on tube current and image noise. Figure 3 illustrates the imaging boundaries of each anatomical region on an AP scout view of the 10-year-old phantom. Each phantom was examined using the quality reference mAs (mAsQR) setting, which is prescribed by the routine examination protocol for a particular anatomical region (Tables 2 and 3). The mean modulated mAsmod value displayed in the system console was recorded upon the end of each helical image.
To compare modulated tube current among different examination protocols applied at the same anatomical region, whole body CT examinations were performed in 5-year-old and adult phantoms using all anatomic-specific routine examination protocols listed in Tables 2 and 3. To facilitate comparison on modulated tube current among protocols, all whole body CT examinations were performed at the same mAsQR setting. Upon the completion of each ATCM-activated whole body acquisition, the modulated tube current–time product (mAsmod) value was manually recorded from the DICOM header of each consecutive reconstructed axial image along the z-axis. These values were used to generate plots of mAsmod(z) profiles.
All CT acquisitions were performed with the ATCM modulation strength set to (i) ‘strong decrease’–‘weak increase’, (ii) ‘average decrease’–‘average increase’ and (iii) ‘weak decrease’–‘strong increase’. These settings were selected because they correspond to the lowest, the average and the highest patient exposure, respectively. The ‘average decrease’/’average increase’ is the default modulation strength set by the manufacturer. All phantoms were accurately aligned with the gantry isocentre, while in the supine position. Each phantom and table increment was kept stable among acquisitions. All ATCM-activated acquisitions were repeated five times to calculate arithmetic averages of the modulated tube current–time product values among images.
To investigate whether the ATCM-activated acquisitions can deliver images of similar noise at reduced radiation dose compared to acquisitions performed with the ATCM system deactivated, the phantoms were subjected to head, neck, thorax and abdomen/pelvis examinations using the routine examination protocols (Tables 1 and 2) at fixed tube current settings (mAsf). The mAsf settings applied were based on the guidelines proposed by the system’s application guide on phantom’s age for head and neck, and phantom’s weight for torso examinations [10]
Quantitative image noise assessment and statistical analysis
To quantitatively assess the effect of ATCM on image quality, image noise was measured as the average standard deviation (SD) of the Hounsfield unit (HU) values across circular 2 cm2 regions of interest (ROI), which were drawn over uniform, tissue-equivalent areas. For head anatomical region, image noise was measured in brain equivalent areas at the level of the central part of the brain parenchyma. For the neck, image noise was measured in soft-tissue equivalent areas at the level of the C4 cervical vertebrae. For the thorax anatomical region, image noise was measured in lung equivalent areas at the level of central part of the lung parenchyma, while for abdomen and pelvis anatomical region, image noise was measured in soft-tissue equivalent areas at the level of L4 lumbar vertebrae. At each anatomical region, image noise was measured for three consecutive image slices. Five ROIs were drawn throughout each image slice. The image noise was then derived from the average of the 15 measurements of the SD values. Quantitative image assessment and analysis was performed using the ImageJ image analysis software (version 1.46r, Java, NIH, USA). Modulated mAs and image noise comparison among phantoms for each acquisition was performed using the Student’s t test for unpaired samples. A significant difference was set at a P value of less than 0.05. Statistical computations were performed using the MedCalc software package (MedCalc software, Belgium).
Results
Table 4 lists the phantoms’ circumference (CIR) measured at specific anatomical sites, along with the corresponding mean modulated mAsmod value, which was recorded upon the completion of each helical CT acquisition. Two mean mAsmod values are tabulated for each CT acquisition. The first was derived from acquisitions performed using the ‘child’ examination protocols, and the second was derived from acquisitions performed using ‘adult’ examination protocols. The mAsmod values for head, neck and thorax are mostly lower in child compared to adult protocols, since mAsQR settings are much lower in child than the corresponding setting for adult protocols. However, for abdomen/pelvis the mAsmod values are higher in child protocols suggesting that ATCM might be less efficient in reducing radiation dose in children. As expected, mAsmod values show an increase trend with CIR. This is more clearly illustrated for the abdomen/pelvis anatomical region, where mAsmod was significantly increased from 45 for neonate to 142 for adult (III) when the ‘child’ abdomen routine examination protocol was selected (P < 0.05). The corresponding increase for the ‘adult’ abdomen examination protocol was from 29 to 86 (P < 0.05) The mAsmod values listed in Table 4 were derived with the ATCM modulation strength setting set to the ‘average decrease’ for slim–‘average increase’ for obese patients. Moreover, as shown in Tables 2 and 4, the mAsQR/mAsmod value in thorax of the 10-year-old was 30/33, and in abdomen/pelvis of 5-year-old, 10-year-old, 10-year-old (I), and 10-year-old (II) was 55/59, 55/69, 55/83, and 55/94, respectively. This finding suggests that ATCM activation may potentially increase patient radiation dose in trunk CT examinations of children older than 5 years.
The effect of altering the modulation strength setting on the resulting mAsmod values as a function of CIR is illustrated in Fig. 4 for ‘child’ (Fig. 4a) and ‘adult’ (Fig. 4b) abdomen routine examination protocols.
Figure 5 illustrates the mAsmod(z) profile curves derived from whole body CT acquisitions of the 5-year-old phantom (Fig. 5a) and the adult phantom (Fig. 5b) using the routine examination protocols for head, neck, thorax and abdomen anatomical regions specified for children and adults, respectively. Although all whole body CT scans were performed at the same mAsQR setting (100), the mAsmod(z) profiles differ substantially among examination protocols.
Table 5 lists the image noise values obtained with fixed tube current acquisitions for each anatomical region and phantom. On average, image noise values were found to be lower for head and neck than for torso acquisitions. For the same anatomical region, the image was found to vary among phantoms. In particular, image noise varied from 1.5 to 5.3 HU for head, 1.9 to 7.8 HU for neck, 9.4 to 35.7 HU for thorax and 9.9 to 24.4 HU for abdomen/pelvis.
Table 6 lists the image noise values measured in the axial images along with the corresponding mAsmod values for each phantom. For each anatomical region, two values are tabulated. These values were derived from CT acquisitions performed using examination protocols specified for children and adults, respectively. Image noise was found to significantly increase from neonate to adult phantom (P < 0.05). This increase was most pronounced in the abdomen and pelvis anatomical region of the phantoms.
Discussion
In this study we used ten anthropomorphic phantoms representing patients of varying age and body size to provide a detailed insight into how the CARE Dose 4D exposure modulation mechanism affects tube current and image noise. The results presented demonstrate quantitatively that mean modulated tube current and image noise are affected by (i) patient size, (ii) the patient target group for which the examination is prescribed (‘child’ versus ‘adult’), (iii) anatomical region (head, thorax, etc.) and (iv) modulation strength setting (strong, average, weak).
Several studies have reported results on the efficiency of ATCM systems in delivering images of diagnostic quality at an optimized patient radiation dose [1–4, 15–22]. These studies have assessed the percentage dose reduction achieved when the ATCM is activated as (mAsmod−mAsQR)/mAsQR %. Once the mAsQR value is selected, the actual mAs is modulated online as the tube rotates around the patient and moves along the patient’s long axis. If the attenuation caused by the examined patient is similar to that of a reference patient, the mAsmod values are expected to be similar to the mAsQR. The data presented in Tables 2, 3 and 4 suggest that the trunk of the reference 5-year-old patient considered by CARE Dose 4D closely matches the trunk of the ATOM phantom simulating the 5-year-old individual used here, but head and neck regions do not. Indeed, the mAsQR/mAsmod in the 5-year-old phantom was 30/30 for thorax and 55/59 for abdomen/pelvis, whereas it was 150/75 for head and 60/38 for neck. Besides, the data presented in Tables 2, 3 and 4 suggest that the size of the reference adult patient considered by CARE Dose 4D seems to be considerably larger than the Rando phantom simulating the average (height 1.73 m, weight 73.5 kg) adult individual. Indeed, the mAsQR/mAsmod was 320/159 for head, 150/67 for neck, 100/63 for thorax and 160/59 for abdomen/pelvis. This finding is further illustrated in the Rando phantom simulating the adult (I), (II) and (III) individuals. Specifically, the mAsQR/mAsmod for abdominal examinations was 160/65, 160/76 and 160/86 for adult (I), adult (II) and adult (III), respectively. Even the largest phantom considered here seems to be much smaller than the average adult considered by the system. These findings indicate the importance of using ATCM in adult examination protocols. Even for average size adult patients, the application of ATCM may result in considerable dose reduction compared to the stable mAs examination, in contrast to what might be a common conviction. Moreover, as shown in Table 4, the mean mAsmod value exceeded the mAsQR by 10 % (33 versus 30) in thorax of the 10-year-old, and by 71 % (55 versus 94) in abdomen/pelvis acquisition of 10-year-old (II) phantom. This finding suggests that in torso CT examinations of children older than 5 years, ATCM activation may increase radiation dose.
A comparison between image noise values obtained from fixed tube current (Table 5) with the corresponding values obtained from ATCM-activated acquisitions (Table 6) reveals that the default mAsQR may be appropriately modified to generate images of similar noise to the corresponding images obtained from fixed tube current acquisitions. In particular, the mAsf and noise values found in fixed tube current acquisitions in abdomen/pelvis of the adult phantom are 160 and 9.9 HU (Table 5). When the same acquisition is performed with the ATCM activated at mAsQR 160, the mean modulated mAsmod applied is 59 (63 % decrease) and the corresponding image noise 14.5 HU (Table 6). To achieve the same image noise (9.9 HU) between two acquisitions the mAsQR/mAsmod should be increased from 160/59 to 192/71 (71 = 59 × \( \sqrt{14.5} \)/\( \sqrt{9.9} \)). Therefore, to achieve images of similar noise between fixed tube current and ATCM acquisitions the dose might be reduced by 56 %. Moreover, in the case of the abdomen/pelvis of the 10-year-old phantom the mAsf and noise values found in fixed tube current acquisitions are 55 and 10.8 HU (Table 5). When the same acquisition is performed with the ATCM activated at mAsQR 55, the mean modulated mAsmod applied is 69 (25 % increase) and the corresponding image noise is 8.5 HU (Table 6). To achieve the same image noise (10.8 HU) between two acquisitions, the mAsQR/mAsmod should be decreased from 55/69 to 49/61 (61 = 69 × \( \sqrt{8.5} \)/\( \sqrt{10.8} \)). Therefore, to achieve images of similar noise between fixed tube current and ATCM acquisitions the dose should be increased by 11 %.
Regarding ATCM-activated examinations, data shown in Table 6 indicate that resulting image noise is elevated as patient body size is increased. This is most clearly seen in the abdomen/pelvis anatomical region, where image noise increased in the adult (III) phantom compared to the average adult by 32 % and decreased in neonate compared to the average 5-year-old child by 28 %. This is consistent with the operation principle of the CARE Dose 4D system, which is designed to alter image noise relative to that obtained for the reference patient [6, 8]. This is based on the notion that different-sized patients require different levels of image noise to maintain diagnostic image quality. When imaging paediatric patients lower image noise, compared to adult patients, is preferred to improve delineation of anatomies of interest. Besides, higher noise levels may be tolerated when examining large-sized patients to avoid increased patient radiation dose.
Our data illustrate how the parameter ATCM ‘modulation strength’ affects the mean modulated tube current, and consequently the resulting image noise, in ATCM-activated examinations of different body regions. As shown in Fig. 4a for paediatric patients, (a) selecting ‘strong’ or ‘weak decrease’ instead of ‘average decrease’ the resulting mean modulated mAs values were found to be lower or higher, respectively, for patients with body size smaller than the average patient considered by the system and (b) selecting ‘strong’ or ‘weak increase’ instead of ‘average increase’ the resulting mean modulated mAs values were found to be higher or lower, respectively, for patients with body size larger than the average patient considered by the system. As shown in Fig. 4b for adult patients, selecting ‘strong’ or ‘weak decrease’ instead of ‘average decrease’ the resulting mean modulated mAs values are lower or higher, respectively. This seems to be valid for the whole range of patient sizes studied here, since as discussed previously even the largest phantom employed seems to be smaller than ‘the average adult individual’ considered by the system. In other words, the selection of even the highest modulation strength setting may not be adequate to appropriately increase mean modulated mAs with respect to mAsQR and deliver images of acceptable noise through the application of an appropriately high mAsmod value.
Our findings indicate that the effect of ATCM on tube current and consequently image noise is dependent on the anatomical region for which a specific examination protocol is designed. This dependence is demonstrated in the mAsmod(z) profiles of Fig. 5. This means that, everything else being equal, a change of the selected examination protocol from thorax to abdomen results in a different ATCM behaviour. These findings may be useful in cases where the volume to be examined includes different anatomical regions. For example, data shown in Fig. 5 indicate that, in whole body trunk ATCM-activated CT examinations (thorax + abdomen/pelvis), lower mAsmod values result when the abdomen/pelvis instead of the thorax protocol is selected. Specifically, when the thorax routine protocol is selected, the mAsmod/noise values at the level of central lung parenchyma for thorax and L4 lumbar vertebrae for abdomen/pelvis are 80/3.8 HU and 62/8.3 HU, respectively (Fig. 5b). However, when the abdomen routine protocol is selected the corresponding mAsmod/noise values are 62/6.5 HU and 47/14.5 HU, respectively (Fig. 5b). Although the thorax protocol produces images with less noise compared to the abdomen protocol, the latter is associated with less patient radiation dose and still provides thoracic images with less noise compared to those obtained when the thorax is examined alone (6.5 HU versus 10.8 HU) and abdominal images of similar noise to those obtained when abdomen/pelvis is examined alone (14.5 HU). Therefore, in whole body trunk ATCM-activated CT examinations, operators should select the abdomen/pelvis protocol rather than the thorax protocol to reduce patient radiation burden. This may be particularly useful in paediatric patients who are considered more radiosensitive than adults.
Clinical image quality was not evaluated in the current study. It should be noted that this study was performed using anthropomorphic phantoms. A further study on a large number of patients at various ages and body habitus is required to investigate the effect of ATCM on clinical image quality. Another limitation of this study is that it was limited to a single ATCM system, which was available in the CT suite installed in our institution. Other CT vendors adopt different concepts in defining the level of diagnostic image quality. It would be interesting to investigate the effect of other ATCM algorithms on radiation dose and image quality in patients of varying age and body size. Moreover, this study was conducted using a 16-row CT system. Modern wide area detector CT systems are equipped with a higher number of detector rows, which feature longer z-axis coverage per tube rotation. There is evidence, however, that the CARE Dose 4D system investigated herein exhibits similar performance in CTs with a different detector configuration built by the same vendor [20].
In conclusion, this study demonstrates that ATCM can reduce patient radiation dose in adult individuals regardless of their body habitus. Overweight adult patients referred for CT imaging can benefit from ATCM activation, regarding the associated absorbed radiation dose, even when the highest available modulation strength setting is selected. On the contrary, ATCM may increase patient radiation dose in trunk CT examinations of children older than 5 years. Moreover, this study shows that whole body trunk ATCM-activated CT examinations should be performed with the abdomen/pelvis rather than the thorax protocol to reduce patient radiation burden. The detailed insight to the operation principles of the complex ATCM mechanism, provided here, may be exploited by CT operators to better understand how ATCM can be clinically implemented and maximize its benefits towards a more efficient radiation dose management in CT imaging.
Abbreviations
- ATCM:
-
Automatic tube current modulation
- CIR:
-
Circumference
- CT:
-
Computed tomography
- HU:
-
Hounsfield unit
- mAsmod :
-
Mean modulated mAs
- ROI:
-
Region of interest
- SD:
-
Standard deviation
- ROI:
-
Region of interest
References
Mulkens TH, Bellinck P, Baeyaert M, Ghysen D, Van Dijck X, Mussen E, Venstermans C, Termote J (2005) Use of an automatic exposure control mechanism for dose optimization in multi–detector row CT examinations: clinical evaluation. Radiology 237:213–223
Rizzo S, Kalra M, Schmidt B, Dalal T, Suess C, Flohr T, Blake M, Saini S (2006) Comparison of angular and combined automatic tube current modulation techniques with constant tube current CT of the abdomen and pelvis. Am J Roentgenol 186:673–679
Kalra M, Maher M, Toth T, Kamath R, Halpern E, Saini S (2004) Comparison of z-axis automatic tube current modulation technique with fixed tube current CT scanning of abdomen and pelvis. Radiology 232:347–353
Papadakis AE, Perisinakis K, Damilakis J (2008) Automatic exposure control in pediatric and adult multi-detector CT examinations: a phantom study on dose reduction and image quality. Med Phys 35:4567–4576
Allen BC, Baker ME, Einstein DM, Remer EM, Herts BR, Achkar JP, Davros W, Novac E, Obuchowski N (2010) Effect of altering automatic exposure settings and image quality reference mAs on radiation dose, image quality, and diagnostic efficacy in MDCT enterography of active inflammatory Crohn’s disease. Am J Roentgenol 195:89–100
McCollough C, Bruesewitz M, Kofler JM (2006) CT dose reduction and dose management tools: overview of available options. Radiographics 26:503–512
Kalra M, Maher M, Kamath R, Horiouchi T, Toth T, Halpern E, Saini S (2004) Sixteen-detector row CT of abdomen and pelvis: study for optimization of z-axis modulation technique performed in 153 patients. Radiology 233:241–249
Solomon JB, Li X, Samei E (2013) Relating noise to image quality indicators in CT examinations with tube current modulation. Am J Roentgenol 200:592–600
Kalra M, Brady T (2006) CARE Dose4D new technique for radiation dose reduction. Siemens Somatom Session 19:28–31
Bredenholler C, Feuerlein U (2006) Somatom sensation 16 application guide. Siemens Medical, Forchheim
Sookpeng S, Martin CJ, Gentle DJ, Lopez-Gonzalez MR (2014) Relationships between patient size, dose and image noise under automatic tube current modulation systems. J Radiol Prot 34:103–123
Söderberg M, Gunnarsson M (2010) The effect of different adaptation strengths on image quality and radiation dose using Siemens Care Dose 4D. Radiat Prot Dosim 139:173–179
Kalra M, Maher M, Toth T, Schmidt B, Westerman B, Morgan H, Saini S (2004) Techniques and applications of automatic tube current modulation for CT. Radiology 233:649–657
Kalender W, Wolf H, Suess C (1999) Dose reduction in CT by anatomically adapted tube current modulation. II. Phantom measurements. Med Phys 26:2248–2253
Papadakis AE, Perisinakis K, Oikonomou I, Damilakis J (2011) Automatic exposure control in pediatric and adult computed tomography examinations: can we estimate organ and effective dose from mean mAs reduction? Investig Radiol 46:654–662
Papadakis AE, Perisinakis K, Damilakis J (2007) Angular on-line tube current modulation in multidetector CT examinations of children and adults: the influence of different scanning parameters on dose reduction. Med Phys 34:2864–2874
Brisse H, Robilliard M, Savignoni A, Pierrat N, Gaboriaud G, De Rycke Y, Neuenschwander S, Aubert B, Rosenwald J (2009) Assessment of organ absorbed doses and estimation of effective doses from pediatric anthropomorphic phantom measurements for multi-detector row CT with and without automatic exposure control. Health Phys 97:303–314
van Straten M, Deak P, Shrimpton P, Kalender W (2009) The effect of angular and longitudinal tube current modulations on the estimation of organ and effective doses in x-ray computed tomography. Med Phys 36:4881–4889
Das M, Mahnken AH, Muhlenbruch G, Stargardt A, Weiss C, Sennst D, Flohr T, Gunther R, Wildberger J (2005) Individually adapted examination protocols for reduction of radiation exposure for 16-MDCT chest examinations. Am J Roentgenol 184:1437–1443
Tack D, De Maertelaer V, Gevenois P (2003) Dose reduction in multidetector CT using attenuation-based online tube current modulation. Am J Roentgenol 181:331–334
Greess H, Lutze J, Nomayr A, Wolf H, Horhorn T, Kalender W, Bautz W (2004) Dose reduction in subsecond multislice spiral CT examination of children by on-line tube current modulation. Eur Radiol 14:995–999
Papadakis AE, Perisinakis K, Raissaki M, Damilakis J (2013) Effect of x-ray tube parameters and iodine concentration on image quality and radiation dose in cerebral pediatric and adult CT angiography. Investig Radiol 48:192–199
Acknowledgements
The scientific guarantor of this publication is Antonios E Papadakis. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional review board approval was not required because this study was performed on anthropomorphic phantoms. Methodology: experimental, performed at one institution.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Papadakis, A.E., Perisinakis, K. & Damilakis, J. Automatic exposure control in CT: the effect of patient size, anatomical region and prescribed modulation strength on tube current and image quality. Eur Radiol 24, 2520–2531 (2014). https://doi.org/10.1007/s00330-014-3309-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-014-3309-4