Abstract
Intracranial vertebral artery (VA) dissection has three clinical presentations: ischemia, hemorrhage, and mass effect. Imaging findings of intracranial VA dissections vary according to clinical presentation. Irregular stenosis or occlusion of the VA is the most common finding in patients with posterior fossa infarction, whereas a dissecting aneurysm is the main feature in those with acute subarachnoid hemorrhage. A chronic, giant, dissecting aneurysm can cause mass effect on the brain stem or cranial nerves, as well as distal embolism. Magnetic resonance imaging is useful for detection of intramural hematomas and intimal flaps, both of which are diagnostic of VA dissection. Multidetector computed tomography angiography is increasingly used for diagnosis of VA dissection. Catheter angiography is still beneficial for evaluation of precise endoluminal morphology of the dissection before surgical or endovascular intervention. Endovascular treatment is now considered a major therapeutic option for patients with a ruptured dissecting aneurysm or a chronic dissecting aneurysm. Anticoagulation therapy is currently considered the initial treatment of choice in patients with posterior circulation ischemic symptoms. Endovascular treatment, such as stent-assisted angioplasty or coil occlusion at the dissection site, can be performed in selected patients with posterior fossa ischemic symptoms.
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Introduction
Vertebral artery (VA) dissection is an important cause of posterior circulation stroke and a common cause of ischemic stroke in young and middle-aged patients. The annual incidence of spontaneous VA dissection can be estimated at 1–1.5 per 100,000 [1].
The VA is divided into four anatomical segments. V1 extends from its origin to its entry into the transverse foramen of cervical vertebra 6 (C6). V2 extends from the transverse foramen of C6 to C1. V3 extends from the exit from the transverse foramen of C1 to the foramen magnum. V4, the intracranial portion of the VA, extends from the foramen magnum to the basilar artery [2]. The intracranial portion of the VA gives rise to three major branches: the posterior inferior cerebellar artery (PICA), the anterior spinal artery, and the posterior spinal artery. The largest branch of the VA is the PICA, which usually arises near the lower end of the olive and supplies the cerebellar hemisphere, inferior vermis, dorsolateral aspect of the medulla oblongata, choroid plexus of the fourth ventricle, and dentate nucleus. An anterior spinal artery arises near the end of the VA and descends anterior to the medulla oblongata to unite with the other anterior spinal artery from the opposite side at the mid-medullary level. Branches from the anterior spinal arteries are distributed to the medulla oblongata. A posterior spinal artery usually arises from the PICA but may come directly from the VA, near the medulla oblongata. Minute medullary arteries arise from the VA and its branches and are distributed widely to the medulla oblongata [3]. Histologic differences in structure exist between intracranial and extracranial VAs. Intracranial VAs have a thicker internal elastic lamina but lack an external elastic lamina, have a thinner adventitia, and have fewer elastic fibers in the media [4, 5].
VA dissection is most frequently found between the C1 and C2 cervical vertebrae (uppermost part of the V2 segment) and between C1 and the entry site into the dura (V3 segment). These segments are tightly fixed to bones (lateral masses of the C1 and C2 vertebral bodies) and the dural attachment and, thus, are most vulnerable to mechanical stress, such as rotation, hyperextension, or hyperflexion movements of the head [5–7]. Intracranial (V4 segment) VA dissections occur less frequently than extracranial VA dissections.
Dissections of the V4 segment can be classified as either traumatic or spontaneous. In the majority of cases, intracranial VA dissection occurs spontaneously. Several risk factors have been associated with spontaneous cervical artery dissection. Hereditary connective tissue disorders, particularly vascular Ehlers–Danlos syndrome, are known risk factors for spontaneous dissections. Other inherited disorders associated with spontaneous dissections include Marfan syndrome, autosomal dominant polycystic kidney disease, and osteogenesis imperfecta type I. Hyperhomocysteinemia, α1-antitrypsin deficiency, and abnormalities of neural crest cells have also been associated with an increased risk of spontaneous cervical dissections [1, 8, 9]. A recent respiratory tract infection was found to be an independent risk factor for spontaneous dissections [10]. This possibility is supported by the finding of seasonal variation in the incidence of spontaneous dissections, with a peak incidence in the fall [11]. Spontaneous dissections have also been reported in association with fibromuscular dysplasia and cystic medial necrosis. Both fibromuscular dysplasia and cystic medial necrosis, however, are nonspecific abnormalities that are associated with a variety of systemic disorders [1].
The pathogenesis of VA dissection is still controversial. It has been suggested that the acute VA dissection is caused by a sudden disruption of the internal elastic lamina (IEL), the most important layer with regard to the strength of the intracranial arterial wall [12, 13]. Subsequent penetration of circulating blood into the wall of the artery creates an intramural hematoma, the so-called false lumen. Recently, in their pathology study of the vertebral artery in patients with VA dissecting aneurysm, Yamada et al. [14] found areas of severe degeneration and calcification in the IEL of the VA wall, just proximal to the aneurysm. They hypothesized that degeneration of the IEL of this type might constitute a predisposing factor and may have led to vascular wall dissection. They also postulated that increased hemodynamic stress on the VA distal to the cervical flexures and around the VA union might contribute to the genesis of IEL degeneration, although they failed to elucidate the precise etiology of the IEL degeneration in their study. However, in several pathology studies of intracranial VA dissection, an intramural hematoma was found without any connection between the false and true arterial lumen [1, 9, 15, 16], which suggests that some VA dissections might be caused by a primary intramural hematoma. It has been suggested that possible causes of primary intramural hematoma are rupture of the vasa vasorum and rupture of new vessels formed in response to medial necrosis [15, 16].
The plane of dissection extends through the tunica media and can be subintimal or subadventitial. A subintimal dissection tends to result in luminal stenosis or occlusion by intramural hematoma. Arterial dissection may cause a dissecting aneurysm when the major dissection plane is subadventitial and the entire vessel wall is widely disrupted [12, 17, 18].
The pathogenesis of chronic dissecting aneurysm also remains unclear. Recently, Krings et al. [19] reviewed and supported the hypothesis that repeated subadventitial bleeding from the new vasa vasorum plays an important role in the pathogenesis of chronic giant dissecting aneurysm, which had been proposed by Schubiger et al. in 1980s [20, 21]. Chronic dissecting aneurysm can progressively increase in size due to the apposition of multiple layers of intramural hematoma of different ages within the vessel wall [19].
The clinical course and prognosis of patients with intracranial VA dissection range from a relatively benign course with no neurologic complications to death from severe brain injury. Clinical presentations of intracranial VA dissection can be categorized into three groups: posterior circulation ischemia or infarction, acute subarachnoid hemorrhage (SAH), and posterior fossa mass effect on the brain stem or cranial nerves [17, 18]. Imaging findings of intracranial VA dissections are also variable and are highly associated with specific clinical presentations. Recently, endovascular treatment has emerged as a major therapeutic option for patients with intracranial VA dissections, especially patients who presented with acute SAH. In this article we present the clinicoradiologic features of VA dissection involving the V4 segment and discuss the endovascular treatment options for these patients.
Clinical manifestations of intracranial vertebral artery dissection
Posterior circulation ischemic symptoms
Unilateral, occipital headache with or without ipsilateral neck pain, followed by progressive onset of ischemic symptoms, is the hallmark of VA dissection [5, 22]. A prospective study found that headache or neck pain occurred in 57 (85%) of 67 patients with VA dissections [23].
Brain stem or cerebellar infarction is the most common clinical presentation of intracranial VA dissection [1]. These infarctions are mainly caused by distal embolization from the dissection site or thrombotic occlusion of branch vessels, rather than hypoperfusion due to arterial stenosis or occlusion [18, 24]. More than 50% of patients with intracranial VA dissection demonstrate symptoms related to brain stem infarction, the most common of which is lateral medullary infarction (Wallenberg syndrome) (Fig. 1), [1, 25]. Intracranial VA dissection is also an important cause of medial medullary infarction. One study found that, in 21% of patients, medial medullary infarction was related to intracranial VA dissection (Fig. 2) [26].
Although prognosis depends on the initial severity of neurologic deficits, intracranial VA dissection presenting with posterior circulation ischemic symptoms carries a relatively good prognosis [25, 27, 28]. In one study, more than 90% of patients who presented with ischemic symptoms subsequently returned to their previous lifestyles [27].
Acute subarachnoid hemorrhage
Acute SAH occurs when a dissecting aneurysm is formed and subsequently ruptures in a patient with intracranial VA dissection (Fig. 3). In contrast to intracranial VA dissections presenting with posterior circulation ischemic symptoms, intracranial VA dissections presenting with acute SAH due to ruptured dissecting aneurysms carry a poor prognosis if left untreated. Yamada et al. [29] reported an overall mortality rate of 67% in 24 patients who underwent conservative treatment after acute SAH caused by ruptured VA dissecting aneurysms. Early rebleeding is frequent and is responsible for a high mortality rate in these patients. Rates of rebleeding of ruptured VA dissecting aneurysms range from 30% to 71% [30]. Rebleeding most often occurs during the hyperacute phase: 57%–93% of rebleeding occurs within 24 h of the first hemorrhage. Reported mortality rates for patients with rebleeding are 47%–71% [29, 30].
Posterior fossa mass effect
Posterior fossa mass effect is a rare manifestation of intracranial VA dissection. A chronic, large, dissecting aneurysm can compress the brain stem or cranial nerves and cause symptoms related to mass effect, including headache, occipital pain, vertigo, vomiting, progressive myelopathy, and lower cranial nerve symptoms, such as dysphagia or hearing loss (Fig. 4) [17, 30]. A chronic dissecting aneurysm may also cause recurrent ischemic symptoms due to emboli from intra-aneurysmal thrombus.
Radiologic manifestations of intracranial vertebral artery dissection
Catheter angiographic findings
Imaging findings of V4 dissections are variable and are highly associated with specific clinical presentations. The most common angiographic findings in intracranial VA dissections are irregular, long segmental stenosis (Fig. 1) and tapered or abrupt occlusion of the V4 segment. These findings are predominantly observed in patients with ischemic symptoms.
In patients with acute SAH, a dissecting aneurysm with proximal and distal stenosis (pearl and string sign) is the typical angiographic finding (Fig. 3). Fusiform aneurysmal dilatation with or without proximal and/or distal stenosis is also common in these patients. On rare occasions, fusiform dissecting aneurysms also cause posterior fossa infarction due to distal thromboembolism (Fig. 2).
Angiographic findings of intimal flap and retention of contrast medium within the pseudolumen on delayed-phase images are diagnostic of VA dissection (Fig. 5). However, these findings are rarely observed. Another characteristic feature of arterial dissection is that angiographic findings may change rapidly within a period of days or even hours [1].
Magnetic resonance imaging and magnetic resonance angiographic findings
Magnetic resonance (MR) imaging is replacing catheter angiography as the imaging study of choice in the diagnosis of intracranial VA dissection [1]. MR imaging is helpful in differentiating VA dissection from other diseases causing luminal stenosis or occlusion, because MR imaging can directly visualize intramural hematomas and intimal flaps (both diagnostic of VA dissection) within VAs. In addition, MR imaging is the modality of choice in the evaluation of acute ischemic lesions in the posterior cranial fossa.
The typical MR imaging finding in VA dissection is an increased diameter of the affected artery, with eccentric narrowing of the arterial lumen caused by an intramural hematoma [25, 31, 32]. The intramural hematoma appears as an iso-intensity or high intensity signal on T1-weighted spin echo images, depending on the age of the hematoma, and may be crescentic, oval, or circumferential (Figs. 1 and 2). Because the high signal intensity of subacute intramural hematomas (methemoglobin) may be obscured by adjacent fat, a fat-suppressed T1-weighted sequence is recommended in patients suspected of having VA dissection. A T2-weighted sequence is not helpful in the diagnosis of intracranial VA dissection, because the high signal intensity of a subacute intramural hematoma can be obscured by adjacent high-signal cerebrospinal fluid [32]. T2-weighted images may be helpful for detecting decreased signal intensity of an acute-stage intramural hematoma (deoxyhemoglobin).
Various MR angiographic techniques have been used to diagnose VA dissection. Projection images of three-dimensional time-of-flight (3D TOF) MR angiography (MRA) may demonstrate patterns similar to those on catheter angiograms, such as vascular luminal narrowing or occlusion and aneurysmal dilatation. However, these MR angiographic findings are nonspecific. Thus, projection images alone are less useful than MR angiographic source images or T1-weighted images with fat saturation [33]. A double lumen with an intimal flap, a specific sign of arterial dissection, is better visualized on source images than on projection images of 3D TOF MRA (Fig. 5). In addition, projection images of 3D TOF MRA are insufficient to separate residual flow from intramural hematoma with high signal intensity [25, 34]. Contrast-enhanced 3D MRA using gadolinium chelates has the advantage of being able to differentiate residual lumen from intramural hematoma and is thus considered the technique of choice for the evaluation of VA dissection [2, 35].
Essential MR sequences for the diagnosis of intracranial VA dissection include axial, non-contrast, fat-suppressed, T1-weighted, spin echo images; axial, T2-weighted, spin echo images; and contrast-enhanced, 3D, MR angiograms covering the region from aortic arch to circle of Willis.
Computed tomography angiographic findings
With the advent of multidetector helical computed tomography (CT), multidetector CT (MDCT) angiography has been increasingly used in the diagnosis of intracranial VA dissection. Axial source images of MDCT angiography afford high-resolution images of the vessel in cross-section, and post-processed images can provide angiographic images at various angles (Fig. 4). Recently, Chen et al. [36] reported that CT angiography is excellent for detecting VA dissection, having a sensitivity of 100% and a specificity of 98%. The most important CT angiographic criteria the researchers used for diagnosing VA dissection were an increased external diameter and crescent-shaped mural thickening.
CT and MR imaging, non-invasive imaging techniques, are now replacing catheter angiography in the diagnosis of intracranial VA dissection. The choice of initial imaging modality for intracranial VA dissection depends on the clinical presentation of the patient. CT and CT angiography are recommended for patients with acute SAH due to a ruptured VA dissecting aneurysm. MR imaging and MRA are preferred for the diagnosis of VA dissection in patients with posterior fossa ischemic symptoms.
Endovascular treatment of intracranial vertebral artery dissection
Acute subarachnoid hemorrhage
Because mortality rates for patients with rebleeding are high, surgical or endovascular interventions should be promptly performed to prevent rebleeding in patients with ruptured dissecting aneurysms. The goal of treatment is to isolate the dissecting aneurysm from the cerebral circulation to prevent re-rupture. A ruptured VA dissecting aneurysm can be excluded from posterior circulation by either open surgery or endovascular treatment. Surgical treatment options include ligation of the proximal VA and direct clipping or trapping of the aneurysms. It has been reported that open surgical procedures are associated with high mortality rates and high rates of postoperative complications, such as lower cranial nerve palsy and brain stem infarction [29, 30, 37].
Endovascular treatment has largely replaced surgery as the treatment of choice for ruptured VA dissecting aneurysms [37–44]. Initially, proximal occlusion of the VA (parent vessel occlusion) with detachable balloons or coils was attempted [45, 46]. However, these procedures are not always effective in preventing re-rupture, and some investigators have reported rebleeding after proximal occlusion [40, 47]. Complete occlusion of the dissecting aneurysm with detachable coils (internal trapping), and concomitant occlusion of the parent artery, is considered the most effective method for treating ruptured VA dissection in the acute stage (Fig. 6). A high technical success rate and a low complication rate have been reported with this technique [38, 40, 41, 44]. Mortality rates for patients treated with endovascular trapping have been reported to be 0%–38% [38–40, 43, 48–50], whereas those for untreated patients range from 36% to 67% [29, 30, 40]. Poor neurologic grade on admission and early rebleeding are predictive of poor clinical outcome after endovascular treatment in patients with VA dissecting aneurysms [42].
VA dissection involving the origin of the PICA, bilateral VA dissections, and VA dissection with a hypoplastic contralateral VA remain therapeutic challenges. Treatment of VA dissection involving the origin of the PICA is problematic because inadvertent occlusion of the PICA might cause brain stem or cerebellar infarctions. In these patients, bypass surgery (occipital artery–PICA anastomosis), followed by endovascular internal trapping of the dissecting aneurysm, is generally recommended [44]. Proximal parent artery occlusion, leaving the aneurysm itself, can be performed emergently to prevent rebleeding before elective bypass surgery or when surgery is contraindicated [40]. Use of an intravascular stent is another therapeutic option for patients with dissecting aneurysms involving the origin of the PICA. Placement of intravascular stents, followed by coil embolization of the pseudoaneurysm, can preserve the arterial lumen while excluding the aneurysm from the circulation (Fig. 7). This technique can also be used in patients with VA dissection with a hypoplastic contralateral VA or in patients with bilateral VA dissections, to preserve adequate blood flow to the posterior circulation [38]. Surgical occlusion to treat a ruptured aneurysm on one side potentially leads to rupture of the contralateral lesion in cases involving dissecting aneurysms of the bilateral VAs [51].
The use of stents in patients with ruptured dissecting aneurysm has several limitations. These “reconstructive” techniques may be associated with aneurysm recurrence and, thus, requires close clinical and angiographic follow-up (Fig. 8), [52]. Use of a stent in an acutely ruptured dissecting aneurysm might also lead to catastrophic complications, such as vessel rupture during placement of the stent or coils. Another problem is that acute thrombotic occlusion of the stent or thromboembolic complications might occur after stent placement, because adequate anticoagulation therapy and antiplatelet therapy are not feasible in the acute stage of SAH [43, 44].
Fusiform dissecting aneurysm can be treated with double-stent placement [53, 54]. Placement of overlapping stents theoretically decreases stent porosity, which may impede intra-aneurysmal blood flow considerably and thus accelerate intrasaccular thrombus formation [53]. Although there are successful case reports of fusiform dissecting aneurysms treated with double stents or stents and subsequent coiling of the aneurysm, this therapy has not been established for larger patient series and must therefore be considered as experimental in nature.
Posterior circulation ischemic symptoms
The goal of treatment in patients with posterior circulation ischemic symptoms caused by intracranial VA dissection is to prevent further thromboembolic events. Although no randomized controlled trials have been performed to determine optimal drug therapy, anticoagulation with intravenously administered heparin followed by oral administration of warfarin is considered the treatment of choice for patients with posterior circulation ischemic symptoms. Anticoagulation with a target international normalized ratio of 2.0–3.0 is generally used for the first 3–6 months [1].
Endovascular treatment has a limited role in the treatment of patients with posterior fossa ischemic symptoms [55, 56]. Endovascular coil occlusion should be considered in patients with ischemic symptoms who have a dissecting aneurysm of “pearl and string” appearance on angiographic images, because VA dissection with this aneurysmal morphology has the potential to grow and subsequently rupture, regardless of initial presentation (Fig. 9) [57]. Stent-assisted angioplasty may be performed in patients who have recurrent symptoms of ischemia despite adequate anticoagulation or in those in whom anticoagulation is contraindicated [56, 58]. Stents allow apposition of the dissected segment to the vessel wall and obliteration of the false lumen and thus can limit the occurrence of further embolic events [59]. It is believed that the risk of vessel rupture is higher than in intracranial atherosclerosis if stent-assisted angioplasty is performed in patients with VA dissection. Thus, extremely slow inflation with a screw-type inflation device is needed to prevent arterial rupture when the balloon is inflated.
Posterior fossa mass effect
A chronic dissecting aneurysm causing mass effect on the brain stem or cranial nerves can be successfully managed by endovascular trapping of the aneurysm (Fig. 10). Complete occlusion of the parent VA proximal and distal to the aneurysm should also be performed, to prevent recanalization of the dissecting aneurysm. Improvement of symptoms related to mass effect after endovascular aneurysm occlusion has been reported in the literature. The mechanism for symptomatic improvement could be the elimination of the persistent pulsation of the aneurysm in close contact with the brain stem, although the mass effect by the coil mass itself remains [60].
It is noteworthy that there are occasional case reports in which chronic, dissecting, thrombosed, giant, aneurysms continued to enlarge, despite the complete thrombosis of the aneurysm [61–64]. The suggested mechanism to account for continued growth after complete endovascular occlusion is the adventitial neovascularization by the vasa vasorum on the occluded VA. Thus, it is recommended that surgical clip placement and resection of the aneurysm should be considered in such cases that are refractory to endovascular treatment [64].
Summary
Imaging findings of intracranial VA dissections vary according to the specific clinical presentation. MR imaging and MDCT angiography, non-invasive imaging techniques, are replacing catheter angiography in the diagnosis of intracranial VA dissection. Endovascular treatment is now considered a major therapeutic option for patients with a ruptured dissecting aneurysm or a chronic dissecting aneurysm. Anticoagulation therapy is currently considered the initial treatment of choice in patients with posterior circulation ischemic symptoms. Endovascular treatment, such as stent-assisted angioplasty or coil occlusion at the dissection site, can be performed in selected patients with posterior fossa ischemic symptoms.
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Yoon, W., Seo, J.J., Kim, T.S. et al. Dissection of the V4 segment of the vertebral artery: clinicoradiologic manifestations and endovascular treatment. Eur Radiol 17, 983–993 (2007). https://doi.org/10.1007/s00330-006-0272-8
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DOI: https://doi.org/10.1007/s00330-006-0272-8