Abstract
The marine diatom Haslea ostrearia was immobilized in a tubular agar gel layer introduced into a photobioreactor of original design with internal illumination for the continuous synthesis of marennin, a blue-green pigment of biotechnological interest. Marennin was produced for a long-term period (27–43 days) and the volumetric productivity was maximum (18.7 mg day−1 l−1 gel) at the highest dilution rate (0.25 day−1) and lowest agar layer thickness (3 mm). Heterogeneous cell distribution in the agar layer revealed diffusional limitation of light and nutrients. However, the 3 mm gel thickness led to a more homogeneous cell distribution during incubation and to an increase of the whole biomass in the agar gel layer.
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Received: 22 October 1999 / Received revision: 14 February 2000 / Accepted: 18 February 2000
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Lebeau, T., Gaudin, P., Junter, GA. et al. Continuous marennin production by agar-entrapped Haslea ostrearia using a tubular photobioreactor with internal illumination. Appl Microbiol Biotechnol 54, 634–640 (2000). https://doi.org/10.1007/s002530000380
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DOI: https://doi.org/10.1007/s002530000380