Abstract
A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4+ 8– T-cell subset in the thymus and a marked decrease in CD4+ T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.
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Received: 15 July 1998 / Revised: 27 October 1998
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Benavides, F., Giordano, M., Fiette, L. et al. Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency. Immunogenetics 49, 413–419 (1999). https://doi.org/10.1007/s002510050514
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DOI: https://doi.org/10.1007/s002510050514