Abstract
The occurrence and environmental risk of eight endocrine disrupting compounds (EDCs), namely dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), nonyl phenol (NP), bisphenol A (BPA), 17α-ethinylestradiol (EE2) and estrone (E1), from four water sources (Pingshantou, Wanfenggang, Shisi, and Shiyi) of Huai River (Huainan section) were investigated in this study. Except for DMP only found in Pingshantou, all of the selected EDCs existed widely in the source water. DMP, DEP, BBP, DBP, NP, BPA, EE2, and E1 had the ranges of nd (cannot be detected)-130 ng/L, 25–310, 76–1351, 431–1299, 215–627, 23–107, nd-0.174, and 0.143–0.334 ng/L, respectively. Therefore, the studied water sources were associated with notable levels of EDCs, wherein the concentrations of BBP, DBP, and NP were much higher than the other five chemicals. The selected EDCs appeared to be higher in upstream than in downstream (p < 0.05) for each water source, suggesting that EDCs were subjected to a decreasing with water flow. Correlation analysis suggests that DEP-BP-DBP, NP-BPA, and EE2-E1 might have the same sources, respectively; and the source of NP, EE2, and E1 was different from that of BBP, BEP and BBP, and DEP, respectively. It was observed that both the TAS (total ambient severity) and RQ (risk quotient) were less than 1, indicating that EDCs in Huai River (Huainan section) posed little or no thread to the health of local inhabitants and ecological environmental.
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Endocrine disrupting compounds (EDCs), including natural androgens, natural estrogens, artificial synthetic androgens and estrogens, phytoestrogens, as well as other industrial compounds, are a heterogeneous group of chemicals, generally present in water environments in very low concentrations and causing adverse effects in living organisms (Zhang et al. 2011; Gmurek et al. 2017). The changes in sex and reproductive ability of animals are an important characteristic of EDCs (Santoro and Melvin 2017). Because the adverse biological effect of EDCs on animals was detected, there has been a raised concern due to their adverse effect to both wildlife and humans (Mirzaei et al. 2016).
EDCs from wastewater, pharmaceuticals, agricultural fertilizers, and wastes of human and animals are constantly released into environment through direct discharge, sewage treatment plant effluent, and through runoff (Carvalho et al. 2016; Tijani et al. 2013; Sackett et al. 2015). As a result, EDCs has been widely detected in different water bodies, such as wastewater effluents (Plahuta et al. 2017; Barber et al.2015), surface water (e.g., Lange et al. 2015; Feng et al. 2016; Sun et al. 2016), sediment (Wang et al. 2016; Bayen et al. 2016), and aquatic organisms (Salgueiro-Gonzalez et al. 2015; Liu et al. 2017), with concentrations ranging from ng/L to μg/L in water.
However, EDCs cannot be completely removed by the conventional water treatment processes (Guo et al. 2017). If these compounds appear in water sources, finally they also will be detected in the effluent of drinking water treatment plants (Padhye et al. 2014; Murray et al. 2017). Even the EDCs in aquatic environments exist with a low level, but still they could lead to unfavorable reactions of the normal hormone function and physiological status in humans (Zhang et al. 2011; Omar et al. 2016). It is, therefore, necessary to detect their levels in water source to evaluate the risks to humans, protect the ecosystem, and provide useful information for drinking water treatment (Feng et al. 2016).
The Huai River with averaged water flow of 4.53 × 1010 m3/year is one of the seven major rivers in China. It originates in Tongbai Mountain in Henan province, flows through southern Henan, northern Anhui, and northern Jiangsu and enters the Yangtze River at Jiangdu, Yangzhou City. Huai River is a very important water source, providing more than 4.0 × 1010 m3/year water for the use of life, industry, agriculture, and municipal engineering of 15 cities from Henan, Anhui and Jiangsu Province, with population of more than 7.5 × 1010. The estimated volume of discharges of wastewater on the river was more than 4.0 × 109 m3/year. In Huainan City from Anhui province, the life of residents (3.8 × 106 persons) and the development of industry and economy are greatly related to Huai River, because this river is almost the only water source with water supply of more than 2.0 × 109 m3/year. Hundreds of studies have reported the occurrence, transport, and fate in source water in China (Li et al. 2010; Dong et al. 2010; Zhang 2011; Feng et al. 2016; Yang et al. 2017). However, the studies were mainly conducted in the water source of Songhua River, Huangpu River, Yellow River, and Yangtze River. Few studies focused on the Huai River have been included in the present investigation. As a result, it is very important to pursue the EDCs appearing in the water sources from Huai River. The objectives of this study were to investigate the concentration and distribution of eight EDCs from the source water of Huai River in the section of Huainan City and to assess the environmental risk.
Materials and Methods
Study Area and Sampling Collection
The sample points were selected based on the consideration that the sample points should not only cover the area from upstream to downstream of the river but also be affected by different human (urban, industrial, and agricultural) activities upstream or in the vicinity. Therefore, based on the geographical location, Shiyi, Shisi, Wangfenggang, and Pingshantou were selected as the representative study sites. Sampling was taken from the upstream, midstream, and downstream of selected water sources during January 2010 (Fig. 1). Water samples were collected using precleaned brown glass bottle and transported to the laboratory immediately after sampling. Temperature, pH, dissolved oxygen (DO), and electrical conductivity (EC) were measured in situ. The water samples were stored under refrigeration at 4 °C until analysis. The analysis was performed within 4 days. In addition to the basic water parameters (Table 1), eight EDCs (dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), nonyl phenol (NP), bisphenol A (BPA), 17α-ethinylestradiol (EE2) and estrone (E1)) were determined. The goals of measuring the basic water parameters were to provide more information of source water and pursue the correlation between these basic water parameters and the selected EDCs.
Chemicals and Materials
Standard compounds, including DMP, DEP, BBP, DBP, NP, BPA, EE2, and E1, are all HPLC grade. All reagents of HPLC grade used (methanol, ether, dichloromethane, and acetonitrile) were obtained from TEDIA (USA). The other chemicals were used as 98% purity. Oasis hydrophilic lipophilic balance (HLB) cartridges (6 cc, 200 mg) (Waters Corporation, USA) and C18 cartridges (3 mL, 200 mg; 3 mL, 500 mg) (BESEP, Germany) were used for solid-phase extraction (SPE).
Sample Preparation
Water samples were filtered through prebaked glass fiber filters (0.45 µm) to remove insoluble materials, adjusted its pH to 7.0 using HCl and extracted using SPE method (Fig. 2). Three liters of source water was extracted using HLB solid-phase extraction cartridges, which had been preconditioned with a 6-mL mixture of methanol and ether (methanol: ether = 5: 95), 6 mL of methanol and 6 mL of water. During extraction, the cartridges were forced under vacuum at a flow rate of ~5 mL/min and then kept under vacuum aspiration for several min to dry the residual water. The cartridges were eluted successively with a 5-mL mixture of methanol and water (methanol: water = 5: 95) and 9-mL mixture of methanol and ether (methanol: ether = 5: 95) with a flow rate of 1 mL/min, and the elution was moved into a brown bottle, which had been added 1 g of anhydrous sodium sulfate to keep for one night. Then, the extract was blown down to 0.5 mL under a nitrogen stream and brought to the volume of 1 mL with methanol for the analysis of DMP, DEP, BBP, and DBP.
One liter of source water was extracted using C18 solid-phase extraction cartridges (3 mL, 500 mg, BESEP), which had been preconditioned with 10 mL of methanol and 10 mL of water. During extraction, the cartridges were forced under vacuum at a flow rate of approximately 4 mL/min. Then, the cartridges were eluted with a 10-ml mixture of methanol and dichloromethane (methanol: dichloromethane = 20: 80) with a flow rate of 4 mL/min. Finally, the extract was blown down to 0.5 mL under a nitrogen stream and then brought to the volume of 1 mL with methanol for the analysis of NP and BPA.
Five liters of source water was extracted using C18 solid-phase extraction cartridges (3 mL, 200 mg, BESEP) preconditioned with 4 mL of methanol and 4 mL of water. For extraction, the cartridges were forced under vacuum at a flow rate of approximately 4 mL/min. After water dropping out, the cartridges were eluted in sequence with 4 mL of water and 5 mL of methanol with a flow rate of 4 mL/min. Finally, the extract was blown down to 0.5 mL under a nitrogen stream and then brought to the volume of 1 mL with acetonitrile for the analysis of EE2 and E1.
High-Performance Liquid Chromatography Analyses
The samples were analyzed by Hitachi L-2000 high-performance liquid chromatography (HPLC) (reversed-phase), wherein a capillary column Kromasil 100-5C18 (reversed phase, 150 mm × 4.6 mm × 5 um) and L-2485 DAD detector were used for the separation of the analyses for DMP, DEP, BBP, and DBP, Apollo C18 (reversed phase column, 250 mm × 4.6 mm × 5 um) and L-2455 fluorescence detector for NP and BPA while Apollo C18 (reversed phase column, 250 mm × 4.6 mm × 5 um) and L-2485 DAD detector for EE2 and E1, respectively. The analysis conditions are summarized in Table 2 and Fig. 3.
Quality Assurance and Quality Control (QA/QC)
Recoveries were first obtained to evaluate the method performance by the analyses of spiked water samples for each chemical. The extraction and cleanup methods resembled the procedure described in the section of “sample preparation.” A solvent and matrix blank were processed through the entire procedure prior to and after every six samples. The limit of detection (LOD) was determined as signal-to-noise ratio of 3:1. The LODs for source water were 0.04 ng/L for DMP, 0.03 ng/L DEP, 0.04 ng/L for BBP, 0.05 ng/L for DBP, 0.01 ng/L for NP, 0.02 ng/L for BPA, 0.12 pg/L for EE2, and 0.22 pg/L for E1 for source water. The recoveries of eight EDCs ranged from 95.3 to 102.2%.
To avoid contamination during the sampling and sample preparation processes, sampling bottles and all glassware involved in the study were cleaned by soaking chromic acid solution overnight, washing three times with tap water, distilled water, acetone and methanol, and burning in an oven at 105 °C for 8 h.
Ambient Severity
Multimedia Environmental Goals (MEG), suggested by the United States Environmental Protection Agency (USEPA), are levels of significant contaminants or degradents (in ambient air, water, or land or in emissions of effluents conveyed to the ambient media) that are judged to be (1) appropriate for preventing certain negative effects in the surrounding populations or ecosystems, or (2) representative of the control limits achievable through technology (USEPA USEP 2004). The ratio of the actual concentration to the MEG is called the Ambient Severity (AS) (Gao et al. 2011). In this paper, the negative effects of certain substance on the surrounding populations and ecosystems are described as health severity (ASH) and ecological severity (ASE), respectively, which are calculated by the following equation:
in which, AS i is ASH or ASE, C i is the environmental exposure concentration and C MEGi is the environmental (health or ecological) target for the chemical i in water, respectively. The grade of AS of specific chemical can be classified as: AS < 1, no any obvious risk; AS > 1, significant potential risk (Liu et al. 2014).
In fact, the synergy and antagonism between the pollutants should be taken into account; therefore, the formula above was amended as follows (Liu et al. 2014):
C im is the lower concentration of molecule i or m and C MEGim is the C MEGi value considering the synergistic or antagonistic effects. When a = 0, there is no synergistic and antagonism; a = 1, there is synergy; a = −1, there is antagonism. However, due to the complex mechanism, C MEGi has not been worked out considering the synergistic or antagonistic effect (Liu et al. 2014). Based on the assumption that not only all organic pollutants have the same AS value and exert the same potential hazards to people and the environment, but also there is a linear relationship between AS and the potential hazards, the effect of various pollutants (Total Ambient Severity, TAS) can be calculated as follows (Liu et al. 2014):
Risk Quotients
Environmental risk assessment on toxic chemicals often employs risk quotient (RQ) to show the risk quantitatively. RQ is a ratio of exposure to effect, typically obtained by dividing an environmental exposure value by a toxicity end-point value (Liu et al. 2014, Peterson 2006). Therefore, RQ can be employed by risk analysts and other decision makers to evaluate whether the value exceeds any predetermined threshold levels of concern (Peterson 2006). It was calculated using the following equation:
To provide a better estimation of the risk, the calculation of RQ can be further elaborated by two approaches:
The best-case RQ (denoted as RQbcs) and the worst-case RQ (denoted as RQwcs) can be used to screen contaminants that may need a more refined analysis. As the RQbcs for a certain pollutant is higher than 1, the risk posed is probably of concern; as the RQwcs is smaller than 1, adverse effects from exposure to the pollutant may be minimal (Liu et al. 2014). When the RQbcs is higher than 1 or RQwcs smaller than 1, there is usually sufficient information to make a judgment on the level of risk without the aid of a more refined risk assessment (Wei et al. 2006).
Results and Discussion
Abundance of EDCs in Studied Source Water
The EDCs along the river are possibly sourced from stormwater runoff from urban and agricultural areas, effluents from wastewater treatment plants, and unorganized discharge of domestic sewage. Table 3 presents the levels of selected EDCs from all the samples. Water samples from all the 12 sampling sites contained detectable concentrations of EDCs, which means that these contaminants are widespread in the studied area. Meanwhile, the presence of the selected compounds in source water varied spatially. DEP, BBP, DBP, NP, BPA, and E1 were quantified in all water samples, with concentration ranges of 25–31, 76–1351, 431–1299, 215–627, 23–107, and 0.143–0.334 ng/L, respectively. EE2 was detected in 11 samples with 1 below LOD, ranging from nd (cannot be detected) to 0.174 ng/L. However, DMP was only quantified in two samples from upstream and midstream of Pinshantou water source, with concentrations of 20–130 ng/L. Overall, the studied water sources were associated with much higher BBP, DBP, and NP than the other five chemicals. Furthermore, correlation between basic water parameter and the level of EDCs was performer, and it is found the level of EDCS was not correlated with the basic water parameter except for NP, which is negatively related to both DO and TOC. This is possibly because NP exerted toxic effect on the Algae (Yang 2013), resulting in decreased biomass (TOC) and weakened photosynthesis.
In addition, the selected EDCs appeared to have a higher level in upstream than in downstream (p < 0.05) for each water source while the concentration of some compound were increased from midstream to downstream (DEP and BPA in Pingshantou, BPA and EE2 in Shisi, DEP and E2 in Shiyi) (Fig. 3), which means that even though all the EDCs were subjected to a decreasing, some chemicals were still input to the water source. Based on the investigation on the activities nearby the water sources, there was no significant industrial discharge of wastewater. Therefore, from midstream to downstream of selected water source the increase of DEP and BPA in Pingshantou was due to the entrance of runoff, BPA and EE2 in Shisi related to the input of runoff and small-scale unorganized discharge of domestic sewage respectively, whereas DEP and E2 in Shiyi also was attributed to the small scale unorganized discharge of domestic sewage. However, it also was observed that the EDCs level was not always reduced or even was increased for some compounds as Huai River went through Huainan City (Fig. 3), which indicates that the Huai River was continuously contaminated by EDCs. Hence, the attention should not only be paid to the water sources area but also the places where input of EDCs possibly occurs.
Comparison with Other Sources Water in China
Table 4 summarizes the levels of selected EDCs appearing in the other water sources of China. In China the concentrations of DMP are mainly <2000 ng/L. However, the DMP from Songhua River and Yangshupu water source was obviously higher, especially in Yangshupu water source where the average of DMP concentration was 124,000 ng/L. For DEP, in the source water from Suzhou City, Changzhou City, Wuxi City, Xuzhou City, and Yancheng City, the related averages were lower than 100 ng/L. Similarly, the relative high concentration of DEP also appeared in Songhua River and Yangshupu water source due to the significant contributors of DMP and DEP in these two places. Among the five cities from Jiangsu province, the content of BBP varied between <1 and 348 ng/L, and the distribution of BBP was greatly related to the economy and industry. The document available shows that the BBP concentration was 10–163,800 ng/L, wherein the highest took place in Songhua River (123,300–163,800 ng/L). It can be concluded that the source water from Huai River has been susceptible to phthalate esters (PAEs) contamination to some extent (Fig. 4).
The concentrations of ∑PAEs (DMP, DEP, BBP, and DBP) ranged from 1251–2960, 773–1985, 739–1699, and 785–1591 ng/L in the source water of Shiyi, Shisi, Wangfengang, and Pingshantou, respectively. Also, BBP and DBP account for the most part of ∑PAEs. So, BBP and DBP were main pollutants of PAEs in the studied water source. Overall, the ∑PAEs concentrations declined as the river flowed down due the effects, such as sorption, dilution, and degradation. However, the increase of specific species of PAEs in the water source should be paid more attention. On the other hand, the concentration of NP and BPA reported in the literatures available varied between <30 (Xiliu River) and 46,700 ng/L (Suzhou City) and between <1380 (Minhang, Shanghai city) and 26,000 ng/L (Yangshupu, Shanghai city), respectively. However, the concentrations of EE2 and E1 are widely reported in the literature. Songhua River might have higher concentrations of EE2 and E1. One-way analysis suggests that the studied water sources have been contaminated by EDCs, especially by BPA (p < 0.05), to a level that should be taken seriously.
Interregional comparisons based on the data available were conducted. The conclusion is that the major rivers in China, including Yangtze River, Yellow River, Songhua River, and Huai River, have been subjected to EDCs pollution to some degree. The levels of EDCs in the water possibly are governed greatly by the chemical industry from upstream reach of water source. Concentrations of EDCs in source water from the cities located at the downstream of the watershed is relatively higher. The EDCs of the water sources from Jiangsu Province (Suzhou, Wuxi, Xuzhou, Yancheng) seem to have lower concentrations than that from the other areas, possibly due to better management for pollution.
Correlation Analysis Between Selected EDCs in the Studied Source Water
Correlation analysis is a useful method to provide the interesting information on the sources and pathways of chemicals based on the assumption that if the compounds come from the same source(s) they are correlated with amounts (Peng et al. 2008; Yoon et al. 2010). In this paper, Pearson Correlation Analysis, which is performed using SPSS (Version 20.0), is employed and the result is summarized in Table 5.
DEP showed a significant relation with four compounds (BBP, DBP, NP, and BPA), BBP with four (DEP, DBP, BPA, and E1), DBP with six (DEP, BBP, NP, BPA, EE2, and E1), NP with five (DEP, DBP, BPA, EE2, and E1), BPA with six (DEP, BBP, DBP, NP, EE2, and E1), EE2 with four (DBP, NP, BPA, and E1) and E1 with five (BBP, DBP, NP, BPA, and EE2), respectively. This result suggests that at least four compounds could appear in same source; and DEP-BP-DBP, NP-BPA, and EE2-E1 might have the same sources, respectively. However, NP was not related to BBP, EE2 was not to BEP and BBP, and E1 was not related to DEP, respectively. Therefore, the source of NP was different from that of BBP, EE2 different from that of BEP, and BBP and E1 was different from that of DEP.
EDCs in water bodies are originally from wastewater, pharmaceuticals, agricultural fertilizers and pesticides, and wastes of human and animals. Considering the use of selected EDCs in life and industry, the surroundings of each water source as well as the environment between the water sources in the studied area, it can be concluded that the DMP only present in Pingshantou water source was possibly from the effluents of domestic sewage treatment plants and the direct discharge of domestic sewage (small scale) and runoff from agricultural area, DEP effluents of industrial wastewater treatment plants, BBP and DBP effluents of industrial wastewater treatment plants and domestic sewage treatment plants, NP and BPA effluents of industrial wastewater treatment plants and domestic sewage treatment plants, as well as the discharge from agricultural area and EE2 and E2 were from the effluents of pharmaceutical wastewater treatment plants and domestic sewage treatment plants and the direct discharge of domestic sewage (small scale), respectively.
Risk Assessment
Health and ecological ambient severity in Huai River (Huainan section) were calculated to evaluate the potential adverse effects from exposure to selected compounds. It has been documented that the TAS for human and ecological health were in the range of 0.15–0.52 for Taihu Lake (Pan and Xie 1994). The human and ecological health risk due to exposure organic pollutants from surface water in Shijiazhuang city were less than 1, with the maximum TAS value 0.80 (Pei and Su 2000). In addition, the ranges of TAS for human and ecological health were found to be 0.13–0.39 and 0.17–0.79 respectively for Liuxihe Reservoir, which supply the drinking water for 60% inhabitants of Guangzhou City (Liu et al. 2013). The calculated TAS of this study is shown in Table 6. The TAS values both for human health risk human and ecological health risk of EDCs in the source water from the Huai River (Huainan section) were less than 1, wherein the highest for human health risk were 1.86E−03 for DMP, 4.43E−03 for DEP, 1.04E−03 for BBP, and 1.86E−02 for DBP. The highest for ecological health risk were 4.33E−03 for DMP, 1.03E−02 for DEP, 2.70E−05 for BBP, and 4.33E−02 for DBP. It is suggested that TAS of source water from the Huai River (Huainan section) were lower than the highest value of healthy severity. The water may pose little or no threat to humans potentially, which also was considered relatively safe from an ecological perspective. Moreover, the highest TAS appearing in the upstream followed by midstream and downstream for each water source; therefore, it is recommended to draw water from downstream of the each water source.
The RQs of EDCs were summarized in Table 7 as estimated for local residents in the Huai River (Huainan section). The RQ analysis was conducted only on the pollutants whose corresponding health guidelines were available. The calculated RQs for most analyses were smaller than unity under both worst-case and best-case scenarios, suggesting that these pollutants posed little or no threat to the health of local consumers.
Due to the lack of native reference values, in China, USEPA reference values have been used commonly to purse the environmental risk of EDCs (Gao et al. 2011; Liu et al. 2014; Li et al. 2015). However, the targeted (suggested) concentration of pollutants from the USEPA may not be completely applicable in China (Wei et al. 2006). For one thing, population susceptibilities (age, immune status, etc.) are greatly related to the adverse health outcome from exposure to contaminants (Fung et al. 2005; Liu et al. 2014), whereas the way and level of exposure are different between Chinese and American. The structures of aquatic ecosystem of between China and America also are inconsistent. These differences may result in different dose–effect on human and ecological system. Therefore, more studies should be performed and different methods should be employed under different applicable conditions. In addition, to provide more recommendations, the genetic data as well the variation of EDCs level as the source water flows to the water plants will be investigated in a future study.
Conclusions
This study investigated the concentration, distribution, and human and ecological health risk of eight EDCs in the source water of Huai River (Huainan section). The studied water sources had been associated with notable levels of EDCs, especially for BBP, DBP, and NP. However, as the water of Huai River went through Huainan City, some EDCs were continuously discharged into Huai River. EDCs in Huai River (Huainan section) posed little or no threat to the health of local consumers and ecological environment. It is a good strategy to draw water from downstream of the each water source, considering the overall decreased threat to the human health and ecological risk with water flow direction for each water source. The rapid economic development of Huainan City had resulted in obvious environmental impacts on the water quality of the Huai River; special attention needs to be paid to diminish the inputs external source of EDCs to avoid the deterioration of water quality of source water. Specifically, more efficient management should be taken to eliminate the input of EDCs, which is not only from the area in the upper reach of water source but also from the runoff and unorganized discharge of home sewage around the water source. Reduction strategies for EDCs also should be designed effectively in a further study on the removal of EDCs both in water plants and wastewater treatment plants.
References
Barber LB, Loyo-Rosales JE, Rice CP, Minarik TA, Oskouie AK (2015) Endocrine-disrupting alkylphenolic chemicals and other contaminants in wastewater treatment plant effluents, urban streams, and fish in the Great Lakes and Upper Mississippi River Regions. Sci Total Environ 517:195–206
Bayen S, Estrada ES, Juhel G, Kit LW, Kelly BC (2016) Pharmaceutically active compounds and endocrine disrupting chemicals in water, sediments and mollusks in mangrove ecosystems from singapore. Mar Pollut Bull 109(2):716–722
Carvalho AR, Cardoso V, Rodrigues A, Benoliel MJ, Duarte E (2016) Fate and analysis of endocrine-disrupting compounds in a wastewater treatment plant in Portugal. Water Air Soil Pollut 227(6):202
Chen Y (2013) Investigation on pollution of nonylphenol in major water bodies, drinking water and dining utensils in Suzhou and the removal efficiency of some water treatment techniques. Dissertation, Suzhou University (in Chinese)
Chen T, Yun X, Na G, Zhang Y, Yao Z (2009) Determination of estrone, estriol, estradiol in seawater by liquid chromatography-tandem mass spectrometry. Chin J Anal Lab 28(11):41–44 (in Chinese)
Dong J, Wang W, Shang K (2010) Water environment health risk assessment of phthalic acid esters in Lanzhou reach of Yellow River. J Agro Environ Sci 29(5):963–968 (in Chinese)
Fang L (2004) The study on the determination and migration of phthalic acid esters environmental hormones. Dissertation, Beijing University of Technology (in Chinese)
Feng L, Yang G, Zhu L, Xu J, Xu X, Chen Y (2016) Distribution and risk assessment of endocrine-disrupting pesticides in drinking water sources from agricultural watershed. Water Air Soil Pollut 227(1):23
Fung C, Zheng G, Connell D et al (2005) Risks posed by trace organic contaminants in coastal sediments in the Pearl River Delta, China. Mar Pollut Bull 50(10):1036–1049
Gao X, Shi X, Cui Y, Li M, Zhang R, Qian X, Jiang Y (2011) Organic pollutants and ambient severity for the drinking water source of western Taihu Lake. Ecotoxicology 20(5):959–967
Gmurek M, Olak-Kucharczyk M, Ledakowicz S (2017) Photochemical decomposition of endocrine disrupting compounds: a review. Chem Eng J 310:437–456
Guo H, Deng Y, Yao Z et al (2017) A highly selective surface coating for enhanced membrane rejection of endocrine disrupting compounds: mechanistic insights and implications. Water Res 121:197–203
Hou S, Xun J, Wang L, Sun H, Dai S, Liu X (2005) Primary study on nonylphenol and nonylphenol polyethoxylates in aquatic environment at lanzhou reach of yellow river. Environ Chem 24(3):250–254 (in Chinese)
Jin X (2004) Analytical method for endocrine-disrupting chemicals of bisphenol A, 4-tert-oetyiphenol, 4-nonylphenol and their distributions in typical districts in Beijing and Tianjin, China. Dissertation, Nankai University (in Chinese)
Lange C, Kuch B, Metzger JW (2015) Occurrence and fate of synthetic musk fragrances in a small German river. J Hazard Mater 282:34–40
Li Y (2006) Test and degradation of endocrine-disrupting chemicals in drinking water. Dissertation, Tongji University (in Chinese)
Li X, Zou S, Luan T, Weng S, Lin L (2010) Distribution of the three phenolic endocrine disrupting chemicals in the water of Pearl River Estuary, Guangdone. J Saf Environ 10(2):96–101 (in Chinese)
Li Z, Xiang X, Li M, Ma Y, Wang J, Liu X (2015) Occurrence and risk assessment of pharmaceuticals and personal care products and endocrine disrupting chemicals in reclaimed water and receiving groundwater in China. Ecotoxicol Environ Saf 119:74–80
Lin X (2003) Study on phthalic acid esters of environmental hormone in water in Beijing area. Dissertation, Beijing University of Technology (in Chinese)
Liu F, Liu L, Zhang R, Qian X, Li M (2013) Ambient severity evaluation and toxicity effect of organic pollutants in Liuxihe Reservoir, China. J Agro Environ Sci 32(4):756–763 (in Chinese)
Liu D, Wu S, Xu H, Zhang Q, Zhang S, Shi L et al (2017) Distribution and bioaccumulation of endocrine disrupting chemicals in water, sediment and fishes in a shallow Chinese freshwater lake: Implications for ecological and human health risks. Ecotox Environ Safe 140:222–229
Liu F, Liu Y, Jiang D, Zhang R, Cui Y, Li M (2014) Health risk assessment of semi-volatile organic pollutants in Lhasa River China. Ecotoxicology 23(4):567–576
Mirzaei A, Chen Z, Haghighat F, Yerushalmi L (2016) Removal of pharmaceuticals and endocrine disrupting compounds from water by zinc oxide-based photocatalytic degradation: a review. Sustain Cities Soc 27:407–418
Murray A, Örmeci B, Lai EP (2017) Use of sub-micron sized resin particles for removal of endocrine disrupting compounds and pharmaceuticals from water and wastewater. J Environ Sci China 51:256–264
Nie M (2012) Occurrence and phase distribution of selected estrogens in the water of the water source protection area of upper reach of Huangpu River. Dissertation, East China Normal University (in Chinese)
Omar TFT, Ahmad A, Aris AZ, Yusoff FM (2016) Endocrine disrupting compounds (EDCs) in environmental matrices: review of analytical strategies for pharmaceuticals, estrogenic hormones, and alkylphenol compounds. TrAC Trends Anal Chem 85:241–259
Padhye LP, Yao H, Kung’u FT, Huang CH (2014) Year-long evaluation on the occurrence and fate of pharmaceuticals, personal care products, and endocrine disrupting chemicals in an urban drinking water treatment plant. Water Res 51:266–276
Pan S, Xie J (1994) Ambient severity evaluation of organic compounds in underground water. Environ Monit China 10(6):35–37 (in Chinese)
Pei Q, Su G (2000) An assessment of healthy severity of surface water source in Shijiazhuang city. Geogr Territ Res 16(1):67–70 (in Chinese)
Peng X, Yu Y, Tang C, Tan J, Huang Q, Wang Z (2008) Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta, South China. Sci Total Environ 397(1):158–166
Peng X, Xiong S, Ou W et al (2017) Persistence, temporal and spatial profiles of ultraviolet absorbents and phenolic personal care products in riverine and estuarine sediment of the Pearl River catchment, China. J Hazard Mater 323:139–146
Peterson RK (2006) Comparing ecological risks of pesticides: the utility of a risk quotient ranking approach across refinements of exposure. Pest Manag Sci 62(1):46–56
Plahuta M, Tišler T, Toman MJ, Pintar A (2017) Toxic and endocrine disrupting effects of wastewater treatment plant influents and effluents on a freshwater isopod Asellus aquaticus (Isopoda, Crustacea). Chemosphere 174:342–353
Sackett DK, Pow CL, Rubino MJ et al (2015) Sources of endocrine disrupting compounds in North Carolina waterways: a geographic information systems approach. Environ Toxicol Chem 34(2):437–445
Salgueiro-Gonzalez N, Turnes-Carou I, Besada V, Muniategui-Lorenzo S, Lopez-Mahia P, Prada-Rodriguez D (2015) Occurrence, distribution and bioaccumulation of endocrine disrupting compounds in water, sediment and biota samples from a European river basin. Sci Total Environ 529:121–130
Santoro G, Melvin SD (2017) Salinity and sensitivity to endocrine disrupting chemicals: a comparison of reproductive endpoints in small-bodied fish exposed under different salinities. Chemosphere 183:186–196
Shao X, Ma J (2008) Preliminary investigation on 13 endocrine disrupting chemicals in the Songhua River. Acta Sci Circum 89:1910–1915 (in Chinese)
Shao X, Ma J, Wen G (2008) Investigation of endocrine disrupting chemicals in a drinking water work located in Songhua River Basin. Environ Sci 29(10):2723–2728 (in Chinese)
Shi W, Zhang FX, Hu GJ et al (2012) Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environ Int 42:117–123
Sun J, Ji X, Zhang R et al (2016) Endocrine disrupting compounds reduction and water quality improvement in reclaimed municipal wastewater: a field-scale study along Jialu River in North China. Chemosphere 157:232–240
Tain H, Shu W, Cao J (2003) Organic pollutants in drinking source water of the Chang River and Jialing River (Chong Reach). Resour Environ Yangtze Basin 12(2):20–25 (in Chinese)
Tijani JO, Fatoba OO, Petrik LF (2013) A review of pharmaceuticals and endocrine-disrupting compounds: sources, effects, removal, and detections. Water Air Soil Pollut 224(11):1770
USEP (United States Environmental Protection Agency) (2004). EPA science inventory. https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=47217&keyword=MEG&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=77067908&CFTOKEN=11711089. Accessed 18 June 2017
Wang X (1995) Separation and analysis of trace phthalic acid esters of environmental samples. Chin J Anal Chem 23(12):1425–1428
Wang L, Lin A, Fan K, Huang C, Zhou H, Hu J, Qang Z (2006) Research on RDCs and NPEOs in water in Beijing. China Water Wastewater 22:284–287 (in Chinese)
Wang Y, Yuan T, Hu Y (2009) Behaviors and environmental risk assessment of estrogenic endocrine disruptors in anaerobic domestic wastewater treatment. Environ Sci 30(6):1716–1720 (in Chinese)
Wang W, Ndungu AW, Wang J (2016) Monitoring of endocrine-disrupting compounds in surface water and sediments of the Three Gorges reservoir region, China. Arch Environ Contam Toxicol 71(4):509–517
Wei S, Lau R, Fung C et al (2006) Trace organic contamination in biota collected from the Pearl River Estuary, China: a preliminary risk assessment. Mar Pollut Bull 52(12):1682–1694
Xu C, Shu WQ, Luo CH (2007) Water environmental health risk assessment of PAHs and PAEs in the three gorges reservoir. Res Environ Sci 20(5):57–60 (in Chinese)
Xu P (2005) Removal performance and mechanism of typical endocrine disrupting chemicals in water. Postdoctoral thesis, Tongji University (in Chinese)
Yan L, Zheng E, Yang X, Cao Q, Ding J, Shi R (2007) Simultaneously determination of bisphenol A and dibutyl phthalate in drinking water by solid-phase extraction and liquid chromatography hyphenated to mass spectrometry. Chinese Journal of Analysis Laboratory 26(6):10–14
Yan R, Cheng W, Pang Y, Liu Y, Pao C (2009) Pollution characteristics of Sunan canal and the solutions. Yangtze River 21:66–70 (in Chinese)
Yang C (2008) Stability tests of oestrone,17β-oestradiol and 17α-ethinyl oestradiol in sewage samples. Chem Res Appl 20(8):965–971 (in Chinese)
Yang J (2013) Distribution and environmental behavior of typical endocrine disrupting chemicals in water environment of Pearl River Delta. Dissertation, University of Chinese Academy of Sciences (in Chinese)
Yang Y, Li C, Li Y, Liang Y (2017) Research on temporal-spatial migration and transformation of typical endocrine disrupting chemicals in the drinking water source area of Chengdu. China Rural Water Hydropower 5:118–123 (in Chinese)
Yi C (2002) The Research of SPE on the environmental endocrine disruptors in sewage. Dissertation, Beijing University of Technology (in Chinese)
Yoon Y, Ryu J, Oh J, Choi BG, Snyder SA (2010) Occurrence of endocrine disrupting compounds, pharmaceuticals, and personal care products in the Han River (Seoul, South Korea). Sci Total Environ 408(3):636–643
Yu Q, Wang H, An K (2008) Determination of estrogens in water by solid phase extraction-high performance liquid chromatography. J Environ Health 25(5):438 (in Chinese)
Zhang X (2001) Reversed phase liquid chromatography for the analysis of phthalic acid esters from sewage. Petrochem Ind Tech 8(4):225–228 (in Chinese)
Zhang F (2011) Bioanalytical and instrumental analysis of thyroid hormone disrupting organics in water source and drinking water in Jiangsu Province. Dissertation, Nanjing University (in Chinese)
Zhang Y (2012) Study on pollution of bisphenol A in major types of water bodies, drinking water and dining utensils in Suzhou and the technique for removing bisphenol A. Dissertation, Suzhou University (in Chinese)
Zhang Z, Feng Y, Gao P, Wang C, Ren N (2011) Occurrence and removal efficiencies of eight EDCs and estrogenicity in a STP. J Environ Monitor 13(5):1366–1373
Acknowledgements
The water plants provided us with the basic information of studied water sources and issued the permission to conduct the sampling in water sources. The authors are grateful for the support.
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Niu, S., Zhang, C. Endocrine Disrupting Compounds from the Source Water of the Huai River (Huainan City), China. Arch Environ Contam Toxicol 74, 471–483 (2018). https://doi.org/10.1007/s00244-017-0445-2
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DOI: https://doi.org/10.1007/s00244-017-0445-2