Abstract.
The eosinophil ribonucleases, eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are two closely related proteins with intriguing functional and evolutionary properties. While both EDN and ECP maintain the structural and catalytic residues typical of the RNase A superfamily, the role of ribonuclease activity in the physiologic function of these proteins remains unclear. The biochemistry and physiology of EDN, ECP and the recently discovered ribonuclease k6 (RNase 6) will be reviewed in this chapter.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Author information
Authors and Affiliations
Additional information
Rights and permissions
About this article
Cite this article
Rosenberg, H. The eosinophil ribonucleases. CMLS, Cell. Mol. Life Sci. 54, 795–803 (1998). https://doi.org/10.1007/s000180050208
Issue Date:
DOI: https://doi.org/10.1007/s000180050208