Abstract
Deoxysugars and the oligosaccharides derived from them belong to one of the most important, but often most neglected, group of biological compounds. As a result of important recent progress in their chemical synthesis as well as insights into their various biochemical aspects, one can expect a major boom in the amount of research devoted to this promising field. In this chapter, the most significant aspects of the biochemistry and chemistry of deoxysugars and deoxysugar-containing oligosaccharides are discussed: (1) biosynthetic, biochemical, and molecular biological studies, including deoxygenation mechanisms, glycosyl transfer, and genes involved in biosynthesis; (2) recent experiments aimed at determining how monoor oligosaccharide moieties of bioactive natural products contribute to biological activity, i. e., the mode of action of these compounds; and (3) synthetic aspects such as chemical glycosidation and enzymatic methods for the construction of deoxysugar oligosaccharides. The information presented here is based on literature published until mid-1996.
Dedicated to Heinz G. Floss.
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Kirschning, A., Bechthold, A.F.W., Rohr, J. (1997). Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides. In: Rohr, J. (eds) Bioorganic Chemistry Deoxysugars, Polyketides and Related Classes: Synthesis, Biosynthesis, Enzymes. Topics in Current Chemistry, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0119234
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