Abstract
Organ blood flow can be quantitatively measured by positron emission tomography (PET). As the liver has dual blood supplies, arterial and portal, regional hepatic blood flow had not been measured quantitatively. However, we succeeded in simultaneously measuring both regional hepatic arterial and portal blood flow by PET in non-stressed patients. Mean regional portal hepatic blood flow in patients with normal liver and cirrhotic liver was 57.5 and 36.7 ml/minutes/100 g, respectively. Mean regional arterial blood flow was 42.5 and 30.7 ml/minutes/100 g, respectively. A significant difference between regional portal hepatic blood flows in normal and cirrhotic patients was noted. Mean regional portal hepatic blood flow in the lateral, medial, anterior, and posterior segments of the liver was 29.8, 43.4, 50.0, and 40.9 ml/minutes/100 g, respectively. Mean regional arterial blood flow in each liver segment was 37.6, 30.0, 28.2, and 31.6 mi/minutes/100 g, respectively. A significant difference between regional portal hepatic blood flows in lateral and anterior segment was noted. The p value was less than 0.025 and the 95 % confidence interval of the difference between means was from −20.2 to −2.7 ml/minutes/100 g by ANOVA. These results showed that regional hepatic blood flow is not the same in all the liver segments.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Huang SC, Carson RE, Phelps ME: Measurement of local blood flow and distribution volume with shortlived isotopes: A general input technique.J Cereb Blood Flow Metab 2: 99–108, 1982
Herscovitch P, Markham J, Raichle ME: Brain blood flow measured with intravenous H2 15O; Theory and error analysis.J Nucl Med 24: 782–789, 1983
Huang SC, Carson RE, Hoffman EJ, Mcdonald N, Barrio JR, Phelps ME: Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and15O-water.J Cereb Blood Flow Metab 3: 141–153, 1983
Bergman SR, Fox KAA, Rand AL, McElvany KD, Welch MJ, Markham JM, Sobel BE: Quantification of regional myocardial blood flow in vivo with H2 15O.Circulation 70: 724–733, 1984
Ketty SS: The theory and applications for the exchange of inert gas at the lungs and tissues.Pharmacol Rev 3: 1–41, 1951
Neider JA, Mead R: A simplex method for function minimization.Computer J 7: 308–313, 1965
Caesar J, Shaldon S, Chiandussi L, Guevara L, Sharlock S: The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function.Clin Sci 21: 43–57, 1961
Moriyasu F, Nishida O, Nakamura T et al: Measurement of portal vascular resistance in patients with portal hypertension.Gastroenterol 90: 710–717, 1986
Moreno AH, Burchell AR, Reddy RV: Portal blood flow in cirrhosis of the liver.J Clin. Invest 46: 436–445, 1967
Shepherd AP, Riedel GL: Kiel JW, Haumschild DJ, Maxwell LC: Evaluation of infrared Laser-Doppler blood flowmeter.Am J Physiol 252: G832-G839, 1987
Sato N, Hagihara, Kamada T, et al: Non destructive measurement of tissue oxidative functions: Measurement of concentration of respiratory enzymes and the rate of oxygen consumption in living liver tissue by reflectance spectrophotometry. In Frontiers in Biological and Energetics, Scarpa A, et al eds. Academic Press, New York, 1978, pp 1507
Sarper R, Fajman WA, Rypius EB, Henderson JM, Tarcan YA, Galambos JT, Warren WD: A non-invasive method for measuring portal venous/total hepatic blood flow by hepatosplenic radionuclide angiography.Radiology 141: 179–184, 1981
Fleming JS, Ackery DM, Walmsley BH, Karran SJ: Scintigraphic estimation of arterial and portal blood supplies to the liver.J Nucl Med 24: 1108–1113, 1983
Rees JR, Reeding VJ, Ashfield R: Hepatic blood-flow measurement with xenon 133; Evidence for separate hepatic-arterial and portal-venous pathway. Lancet 2: 562–563, 1964
Yasuhara Y, Miyauchi S, Hamamoto K: A measurement of regional portal blood flow with Xe-133 and balloon catheter in man.Eur J Nucl Med 15: 346–350, 1989
Hollenberg M, Dougherty J: Liver blood flow measured by portal venous and hepatic arterial routes with Kr85.Am J Physiol 210: 926–932, 1966
Lautt WW, Legare DJ, Ezzat WR: Quantitation of hepatic arterial buffer response to graded change in portal blood flow.Gastroenterology 98: 1024–1028, 1990
Tilyou SM: Yesterday, today, and tomorrow: The evolution of positron emission tomography.J Nucl Med 32: 15N-26N, 1991
Huang SC, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, Phelps ME: Quantitative measurement of local cerebral blood flow in humans by position computed tomography and15O-water.J Cereb Blood Flow Metab 3: 141–153, 1983
Chilton HM, Hawkins RA, Maddahi JM, Phelps ME, Hubner KF, Frick MP: Planning and financing a PET center.J. Nucl Med 32: 35N-51N, 1991
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Taniguchi, H., Oguro, A., Takeuchi, K. et al. Difference in regional hepatic blood flow in liver segments —Non-invasive measurement of regional hepatic arterial and portal blood flow in human by positron emission tomography with H2 15O—. Ann Nucl Med 7, 141–145 (1993). https://doi.org/10.1007/BF03164957
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164957