Summary
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1.
Fifty-seven determinations of functional residual capacity (FRC) were performed by the closed-circuit helium dilution technique in both conscious and anaesthetized subjects breathing 100 per cent oxygen. In all these subjects we demonstrated the occurrence of miliary atelectasis as indicated by a decrease in FRC and arterial oxygen tension.
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2.
Thirty-seven determinations were repeated in subjects breathing a 50 per cent oxygen-50 per cent nitrogen mixture. In these instances, neither FFC nor arterial oxygen tension was found to undergo significant change.
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The importance of denitrogenation and renitrogenation as related to anaesthesia is emphasized,
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Our study suggests that the lung marifestations of hyperoxia might not be entirely related to the toxicity of oxygen itself, but to the lack of adequate nitrogenation.
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Déry, R., Pelletter, J., Jacques, A. et al. Alveolar collapse induced by enitrogenation. Can. Anaes. Soc. J. 12, 531–544 (1965). https://doi.org/10.1007/BF03004416
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DOI: https://doi.org/10.1007/BF03004416