Abstract
Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits ofOpuntia ficus-indica var.saboten Makino throughin vitro bioassay-guided isolation for the inhibition on monoamine oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Alard, D., Wray, V., Grotjahn, L., Reznik, H. and Strack, D., Neobetanin: isolation and identification fromBeta vulgaris.Phytochemistry, 24, 2383–2385 (1985).
Chung, M.-S. and Kim, K. H., Stability of betanine extracted fromOpuntia ficus-indica var.saboten.Korean J. Food Sci., 12, 506–510 (1996).
Han, Y. N., Noh, D. B. and Han, D. S., Studies on the monoamine oxidase inhibitors of medicinal plants I. Isolation of MAO-B inhibitors fromChrysanthemum indicum.Arch. Pharm. Res., 10, 142–147 (1987).
Impellizzeri, G. and Piattelli M., Biosynthesis of indicaxanthin inOpuntia ficus-indica fruits.Phytochemistry, 11, 2499–2502 (1972).
Jeong, S. J., Jun, K. Y., Kang, T. H., Ko, E. B. and Kim, Y. C., Flavonoids from the fruits ofOpuntia ficus-indica var.saboten.Kor. J. Pharmacogn., 30, 84–97 (1999).
Kim, I.-W., Kim, M.-H., Kim, H.-M., and Kim, Y.-E., Effect of antioxidants on the thermostability of red pig-ment in prickly pear.Korean J. Food Sci. Technol., 27, 1013–1016 (1995).
Lee, Y.-C., Hwang, K. H., Han, D. H. and Kim, S. D., Compositions ofOpuntia ficus-indica.Korean J. Food Sci. Technol., 29, 847–853 (1997).
Lee, Y.-C., Shin, K.-A., Jeong, S.-W., Moon, Y.-I., Kim, S.-D., and Han, Y.-N., Quality characteristics of wet noodle added with powder ofOpuntia ficus-indica.Korean J. Food Sci. Technol., 31, 1604–1612 (1999).
McGarvie, D. and Parolis, H., The acid-labile, peripheral chains of the mucilage ofOpuntia ficus-indica.Carbohydrate Research, 94, 57–65 (1981).
Park, E. H., Hwang, S.-E. and Kahng, J.-H., Anti-inflammatory activity ofOpuntia ficus-indica.Yakhak Hoeji, 42, 621–626 (1998).
Ryu, S. Y., Han, Y. N. and Han, B. H., Monoamine oxidase-A inhibitors from medicinal plants.Arch. Pharm. Res., 11, 230–239 (1988).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Han, Y.N., Choo, Y., Lee, YC. et al. Monoamine oxidase B inhibitors from the fruits ofOpuntia ficus-indica var.saboten . Arch Pharm Res 24, 51–54 (2001). https://doi.org/10.1007/BF02976493
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02976493