Abstract
Fourteen kinds of medicinal plants were screened for determining inhibitory activities on monoamine oxidase B. The extracts ofArtemisia Messer-Schmidtiana (herba),Chrysanthemum indicum (flos),Ericibe obtusifolia (radix et rhizoma) andSophora japonica (flos) strongly inhibited the enzyme. Among them, Chrysanthemi flos was chosen for elucidating its active principles, and some flavonoids were isolated and identified as acacetin (I), 5,7-dihydroxy chromone (II), diosmetin (III), apigenin (IV), eriodictyol (V) and luteolin (VI). IC50-dihydroxy chromone (II), diosmetin (III), apigenin (IV), eriodictyol (V) and luteolin (VI). IC50 were determined as following: I, 2.46; II, 0.19; III. 2.11mM, and the others showed weak inhibition.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Literature Cited
Neff, N.H. and Yang, H.-Y.T.: Another look at the monoamine oxidases and the monoamine oxidase inhibitor drugs.Life Sci. 14, 2061 (1974).
Fowler, C.J., Callingham, B.A., Mantle, T.J. and Tipton, K.F.: Monoamine oxidase A and B: a useful concept?Biochem. Pharmac. 27, 97 (1978).
Cawthon, R.M., Pintar, J.E., Haseltine, F.P. and Breakefield, X.O.: Differences in structure of A and B forms of human monoamine oxidase.J. Neurochem. 37, 363 (1981).
Ban, T.A.: Psychopharmacology, Williams & Wilkins, Baltimore (1969).
Quitkin, F., Rifkin, A. and Klein, D.F.: Monoamine oxidase inhibitors: a review of antidepressant effectiveness.Archs gen. Psychiat. 36, 749 (1979).
Riederer, P., Reynolds, G.P., Jellinger, K., Seemann, D. and Danielczyk, W.: Tranylcypronine isomers in Parkinson’s disease. Effect of low doses on monoamine oxidase inhibition and blood pressure response.Modern Problems of Pharmacopsychiatry Vol. 19 Monoamine oxidase and its selective inhibitors. S. Karger, p 154 (1983).
Birkmayer, W., Knoll, J. Riederer, P. and Youdim, M.B.H.: (−)-Deprenyl leads to prolongation of L-dopa efficacy in Parkinson’s disease. Vol. 19 p 231 (1983).
Stern, G.M., Lees, A.J., Hardie, R., and Sandler, M.: Clinical and pharmacological aspects of (−)-deprenyl treatment in Parkinson’s disease. p. 231 (1983).
Rigal, F. and Zarifian, E.: MAO inhibitors in psychiatric therapy: effects and side effects., p 162 (1983).
Marley, E.: Monoamine oxidase inhibitors and drug interactions; in Grahame-Smith,Drug Interactions, p 171, Macmillan, London (1977).
Abeies, R.H. and Maycock, A.L.: Suicide enzyme inactivators.Acc. Chem. Res. 9, 313 (1976).
Singer, T.P. and Salach, J.I.: Interaction of suicide inhibitors with the active site of monoamine oxidase; in Youdim, Paykel,Monoamine oxidase inhibitors-the state of the art, p 17, Wiley, Chichester (1981).
Tipton, K.F. and Mantle, T.J.: The inhibition of rat liver monoamine oxidase by clorgyline and deprenyl,ibid. in Youdim, Paykel,Monoamine oxidase inhibitors-the state of the art, p. 17, Wiley, Chichester, p 3 (1981).
Stoiaova-Ivanova, B., Budzikiewicz, H., Koumanova, B., Tsoutsoulova, A., Mladenova, K. and Brauner, A.: Essential oil ofChrysanthemum indicum.Planta Medica 49, 236 (1983).
Uchio, Y., Tomosue, K., Nakayama, M., Yamamura, A. and Waki, T.: Constituents of the essential oils from three tetraploid species of Chrysanthemum.Phytochem. 20, 2691 (1981).
He, Y., Li, R. and Li, S.: Separation and identification of flavonoids from the flower ofChrysanthemum indicum L..Chem. Abs. 98, 68830z (1983).
Chatterjee, A., Sarkar, S. and Saha, S.K.: Acacetin 7-O-β-d-galactopyranoside fromChrysanthemum indicum.Phytochem. 20, 1760 (1981).
Han, B.H., Park, J.H., Park, M.H. and Han, Y.N.: β-Carboline alkaloids ofPolygala tenuifolia.Arch. Pharm. Res. 8, 243 (1985).
Kermank, W.O., Perkin, W.H. and Robinson, R.: Harmine and harmaline Part V, the synthesis of norharman.J. Chem. Soc. 119, 1602 (1921).
Zeller, E.A.: Oxidation of amines, in Sumner, J.B., Myrbäck (eds.),The Enzymes, 1st ed. Vol II. Academic Press, New York, p 536 (1951).
Mabry, T.J., Markham, K.R. and Thomas, M.B.:The systematic identification of flavonoids p 52 Springer, New York (1970).
Timmermann, B.N., Mues, R., Mabry, T.J. and Powell, A.M.: 6-Methoxyflavonoids fromBrickellia laciniata (Compositae).Phytochem. 18, 1855 (1979).
Brieskorn, C.H. and Riedel, W.: Flavonoids fromColeus amboinicus.Planta Medica 31, 308 (1977).
Harbone, J.B., Mabry, T.J. and Mabry, H.:The flavonoids, Academic Press, New York (1975).
Wollenweber, E.: Flavones and flavonols in exudate ofSalvia glutinosa.Phytochem. 13, 753 (1974).
Bourweig, D. and Pohl, R.:Planta Medica 24, 304 (1973).
Ho, B.T.: Monoamine oxidase inhibitors.J. Pharm. Sci. 61, 82 (1972).
Han, Y.N., Ryu, S.Y. and Han, B.H.: unpublished data
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Han, Y.N., Noh, D.B. & Han, D.S. Studies on the monoamine oxidase inhibitors of medicinal plants I. Isolation of MAO-B inhibitors fromChrysanthemum indicum . Arch. Pharm. Res. 10, 142–147 (1987). https://doi.org/10.1007/BF02857780
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02857780