Abstract
Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots ofAgastache rugosa (Labiatae). Compound1 and2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with IC50 values of 360 and 87 μM, respectively.
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Chen, K., Shi, Q., Fujioka, T., Zhang, D. C., Hu, C. Q., Jin, J. Q., Kilkuskie, R. E., and Lee, K. H., Anti-AIDS agents 4. Tripterifordin, a novel anti-HIV principle fromTripterygium wilfordii: isolation and structural elucidation.J. Nat. Prod., 55, 88–92 (1992).
Chen, K., Shi, Q., Fujioka, T., Nakano, T., Hu, C. Q., Jin, J. Q., Kilkuskie, R. E., and Lee, K. H., Anti-AIDS agents 4. Neotripterifordin, a novel anti-HIV principle fromTripterygium wilfordii: isolation and structural elucidation.Bioorg. Med. Chem., 3, 1345–1348 (1995).
El-Mekkawy, S. Meselhy, M. R., Nakamura, N., Tezuka, Y., Hattori, M., Kakiuchi, N., Shimotohno, K. Kawahata, T., and Otake, T., Anti-HIV and anti-HIV-protease substances fromGanoderma lucidum Phytochemistry, in press (1998).
Gustafson, K. R., Cardellina II, J. H., McMahon, J. B., Gulakowski, R. J., Ishitoya, J., Szallasi, Z., Lewin, N. E., Blumberg, P. M., Weislow, O. S., Beutler, J. A., Buckheit Jr. R. W., Cragg, G. M., Cox, P. A., Bader, J. P., Boyd, M. R., A non-promoting phorbol from the Samoan medicinal plantsHomalanthus nutans, inhibits cell killing by HIV-1.J. Med. Chem. 35, 1978–1986 (1992).
Henderson, L. E., Benveniste, R. E., Sowder, R., Copeland, T. D., Schultz, A. M., and Oroszlan, S., Molecular characterization of gag proteins from simian immunodeficiency virus (SIVMne).J. Virol., 62, 2587–2585 (1988).
Ido, E., Han, H. P., Kezdy, F. J., and Tang, J., Kinetic studies of human immunodeficiency virus type I protease and its active-site hydrogen bond mutant A28S.J. Biol. Chem., 266, 24359–24366 (1991).
Kusumoto, I. T., Nakabayashi, T., Kida, H., Miyashiro, H., Hattori, M., Namba, T., and Shimotohno, K., Screening of various plants extracts used in Ayurvedic medicine for inhibitory effects on human immuno-deficiency virus type-1 (HIV-1) protease.Phytother. Res., 9, 180–184 (1995).
Lee, H. K., Byon, S. J., Oh, S. R., Kim, J. I., Kim, Y. H. and Lee, C. O., Diterpenoids from the roots ofAgastache rugosa and their cytotoxic activities.Kor. J. Pharmacog., 25, 319–327 (1994).
Lee, H. K., Oh, S. R., Kim, J. I., Lee, C. O., Agastaquinone, a new cytotoxic diterpenoid quinone fromAgastache rugosa.J. Nat. Prod. 58, 1718–1721 (1995).
Matsuse, I. T., Nakabayashi, T., Lim, Y. A., Hussein, G., Miyashiro, H., Kakiuchi, N., Hattori, M., Stardjo, S. and Shimotohno, K., A human immunodeficiency virus protease inhibitory substance fromSwietenia mahagoni.Phytother. Res., 11, 433–436 (1997).
Min, B. S., Nakamura, N., Miyashiro, H., Bae, K. H., and Hattori, M., Triterpenes from the spores ofGanoderma lucidum and their inhibitory activity against HIV-1 protease.Chem. Pharm. Bull., 46, 1607–1612 (1998).
Mitsuya, H. and Broder, S., Strategies for antiviral therapy in AIDS.Nature 325, 773–778 (1987).
Piacente, S., Aquino, R., De Tommasi, N., Pizza, C., Lock De Ugaz, O., Chevez Orellana, H., and Mahmood, N., Constituents ofWerneria ciliolata and theirin vitro anti-HIV activity.Phytochemistry, 36, 991–996 (1994).
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Min, B.S., Hattori, M., Lee, H.K. et al. Inhibitory constituents against HIV-1 protease fromAgastache rugosa . Arch Pharm Res 22, 75–77 (1999). https://doi.org/10.1007/BF02976440
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DOI: https://doi.org/10.1007/BF02976440