Summary
In order to evaluate the expression of HLA-DR antigen in glandular cells in eutopic and ectopic endometrium in patients with endometriosis, 19 infertile patients with endometriosis were analyzed immunohistochemically by labelled streptavidin biotin (LSAB) method. Nineteen infertile patients without endometriosis were studied as controls. The results showed that the expression of HLA-DR antigen in the glandular cells in both eutopic and ectopic endometrium was increased significantly as compared with that in the controls (P<0.01). It is likely that aberrant expression of HLA-DR antigen in endometriotic tissue is involved in abormal immunogenesis of endometriosis.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Halme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am J Obstet Gynecol, 1984, 148: 85
Gleicher N. The role of humoral immunity in endometriosis. Acta Obstet Gynecol Scand Suppl, 1994, 159: 15
Gleicher N, Ei-Roeiy A, Confino Eet al. Is endometriosis an autoimmune disease? Obsete Gynecol, 1987, 70: 115
American Fertility Society. Revised American Fertility Society classification of endometriosis: 1985. Feril Steril, 1985, 43: 351
Hanafusa T, Fujino-Rurihara H, Miyazaki Aet al. Expression of class II major histocompatibility complex antigen on pancreatic B cells in the NOD mouse. Lancet, 1983, 11: 1115
Bottazzo G F, Dear B M, McNally I Met al. In situ characterization of autoimmune phenomena and expression of HLA molecules in the panereas in diabetic insulitis. N Engl J Med, 1985, 313: 353
Tabibzadeh S S, Bettica A, Gerber M A. Variable expression of Ia antigens in human endometrium and in chronic endometritis. Am J Clin Pathol, 1986, 86: 153
Kreiner D, Fromowitz F B, Richardson D Aet al. Endometrial immunofluorescence associated with endometriosis and pelvic inflammatory disease. Fertil Steril, 1986, 46: 243
Ota H, Maki M. content of immunoglobulin G and complent components C3 and C4 in endometriotic tissue or endometrium in women with adenomyosis or endometriosis. Med Sci Res, 1990, 18: 727
Ota H, Igarashi S. Expression of major histocompatibility complex class II antigen in endometriotic tissue in patients with endometriosis and adenomyosis. Fertil Steril, 1993, 60: 834
Author information
Authors and Affiliations
Additional information
Liu Yi, male, born in 1968, Associate Professor
Rights and permissions
About this article
Cite this article
Yi, L., Lilan, L. & Haibo, Z. Immunohistochemical study of HLA-DR antigen in endometrial tissue of patients with endometriosis. Current Medical Science 22, 60–61 (2002). https://doi.org/10.1007/BF02904791
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02904791