Abstract
Antifungal activity of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of the composition Cu(2-MeSNic)2(MeNia)2·4H2O (where MeNia isN-methylnicotinamide), and Cu(2-MeSNic)2(Nia)2·2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide, iNia, or ethyl nicotinate, EtNic) were tested on various strains of filamentous fungi by the macrodilution method. Most sensitive against copper(II) adducts with bioactive ligands wereRhizopus oryzae andMicrosporum gypseum (IC50 1.5–2.3 mmol/L). The adducts with Nia, MeNia and EtNic at 5 mmol/L induced morphological changes in growing hyphae ofBotrytis cinerea, mainly their intensive branching attached to release of cytoplasm with partial growth inhibition. Inhibition of sporulation (>90%) ofAlternaria alternata by Cu(2-MeSNic)2·H2O was observed as a change in the color of the colonies. The highest resistance was marked byB. cinerea andFusarium moniliforme (average IC50 values 4.25 and 3.13 mmol/L, respectively). The presence of all bioactive ligands in copper(II) complexes caused an increase in the inhibition effect against model fungi (except significant inhibition activity of EtNic onR. oryzae).
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Bláhová M., Sokolík J., Lahitová N., Murín A.: Mutagenic activity of phenoxyacetatocopper(II) complexes.Čes. Slov. Farm. 43, 240–242 (1994).
Bláhová M., Tûmová I., Sokolík J., Orosová I., Švec P.: Antiinflammatory activity of (cresoxyacetato)copper(II) complexes.Čes. Slov. Farm. 47, 166–169 (1998).
Čík G., Bujdanová H., Sersen F.: Study of fungicidal and antibacterial effect of the Cu(II)-complexes of thiophene oligomers synthesized in ZSM-5 zeolite channels.Chemosphere 44, 313–319 (2001).
Dudová B., Hudecová D., Pokorný R., Mikulášová M., Palicová M., Segl'a P., Melník M.: Copper complexes with bioactive ligands. Part I. Antimicrobial activity.Folia Microbiol. 46, 379–384 (2001).
Gabriel J., Shah V., Nesměrák K., Baldrian P., Nerud F.: Degradation of polycyclic aromatic hydrocarbons by the copper(II)-hydrogen peroxide system.Folia Microbiol. 45, 573–575 (2000).
Hudecová D., Jantová S., Melník M., Uher M.: New azidometalkojates and their biological activity.Folia Microbiol. 41, 473–476 (1996).
Hudecová D., Varečka L', Vollek V., Betina V.: Growth and morphogenesis ofBotrytis cinerea. Effects of exogenous calcium ions, calcium channel blockers and cyclosporin A.Folia Microbiol. 39, 269–275 (1994).
Mikloš D., Segl'a P., Palicová M., Kopcová M., Melník M., Valko M., Glowiak T., Koraibik M., Mrozinski J.: Synthesis, spectral and magnetic properties, and crystal structures of copper(II) 2-methylthionicotinate adducts with chelating ligands.Polyhedron 20, 1867–1874 (2001).
Mikulášová M., Szabová E., Melník M.: Antimutagenic effect of copper(II) complexes.Biologia 53, 719–726 (1998).
Moncol' J., Koman M., Melník M., Černáková, M., Glowiak T.: Study of copper(II) chloro- and dichloropropionates, crystal and molecular structure oftrans-bis(methyl-3-pyridylcarbamate)bis(α,α-dichloropropionato)copper(II).Polyhedron 19, 2573–2577 (2000).
Sokolík J., Bláhová M., Lučanská B., Mlynarčík D., Valent A., Andrezálová L., Švajlenová O., Žemlička M.: Antimicrobial activity of selected aqua-carboxyl-cupric complexes.Čes. Slov. Farm. 41, 40–46 (1992).
Strigáčová J., Hudecová D., Varečka L', Lásiková A., Végh D.: Some biological properties of new quinoline-4-carboxylic acid and quinoline-4-carboxamide derivatives.Folia Microbiol. 45, 305–309 (2000).
Urbančíková M., Jantová S.: The effect of Cu2+ complex induces partial restoration of actin filamentous structures in transformed cells. (In Slovak)Vojenské zdravotnícke listy, Suppl. 66, 16–17 (1997).
Author information
Authors and Affiliations
Corresponding author
Additional information
Part I: Copper complexes with bioactive ligands. Antimicrobial activity.Folia Microbiol.46, 379–384 (2001).
Rights and permissions
About this article
Cite this article
Dudová, B., Hudecová, D., Pokorný, R. et al. Copper complexes with bioactive ligands. Folia Microbiol 47, 225–229 (2002). https://doi.org/10.1007/BF02817642
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02817642