Abstract
The aim of the study was to simulate gastric electrical stimulation using a computer model of gastric electrical activity and suggest a possible avenue toward reliable gastric pacing. Modeling was based on the conoidal dipole model of gastric electrical activity described earlier. It was assumed that local, nonpropagated contractions can be produced circumferentially using 4 rings of stimulating electrodes supplied with 2-sec phase-locked bipolar trains of 50 Hz, 15 V (peak to peak) rectangular voltage. Temporal and propagation organizations of gastric electrical activity described in the conoidal dipole model were used to derive the geometry of the stimulating electrodes and the time shifts for phase-locking of the electrical stimuli applied to the different circumferential electrode sets. The major assumptions and findings of the model were tested on two unconscious dogs. The model produced completely controllable simulated gastric contractions that could be propagated distally by phase-locking the stimulating voltage. The values of interelectrode distances in different rings, as well as the distances between the successive rings, were also derived. The concept of invoked circumferential contractions that are artifically propagated by phase-locking the stimulating voltage could be an avenue toward reliable gastric pacing of gastroparetic patients.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Bellahsene, B. E., C. D. Lind, B. D. Schirmer, O. L. Updike, and R. W. McCallum. Acceleration of gastric emptying with electrical stimulation in a canine model of gastroparesis.Am. J. Physiol. 262 (5 Pt. 1):G826-G834, 1992.
Berger, T., J. Kewenter, and N. G. Kock. Response to gastrointenstinal pacing: antral, duodenal and jejunal motility in control and postoperative patients.Ann. Surg. 164:139–144, 1965.
Chen, J. D., B. D. Schirmer, and R. W. McCallum. Serosal and cutaneous recordings of gastric myoelectrical activity in patients with gastroparesis.Am. J. Physiol. 266(1 Pt. 1): G90-G98, 1994.
Daniel, E. E., and S. K. Sarna. Distribution of excitory vagal fibers in canine wall to control motility.Gastroenterology 71:608–613, 1976.
Familoni, B. O., T. L. Abell, G. Voeller, A. Salem, O. Gaber, and D. Nemoto. Long-term electrical stimulation of the human stomach.Gastroenterology 106:A496, 1994.
Mintchev, M. P., and K. L. Bowes. Conoidal dipole model of the electrical field produced by the human stomach.Med. Biol. Eng. Comput. 33:179–185, 1995.
Mirrizzi, N., R. Stella, and U. Scafoglieri. A model of extracellular waveshape of the gastric electrical activity.Med. Biol. Eng. Comput. 23:33–37, 1985.
Mirrizzi, N., R. Stella, and U. Scafoglieri. Model to simulate the gastric electrical control activity on the stomach wall and on abdominal surface.Med. Biol. Eng. Comput. 24:157–163, 1986.
Sarna, S. K., K. L. Bowes, and E. E. Daniel. Gastric pacemakers.Gastroenterology 70:226–231, 1976.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mintchev, M., Bowes, K. Computer model of gastric electrical stimulation. Ann Biomed Eng 25, 726–730 (1997). https://doi.org/10.1007/BF02684849
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02684849