Abstract
The LD50 oral ingestion values for the common commercial fatty acids are in the range which are considered nontoxic; 24 hour primary skin irritation is considered positive for octanoic acid but negative for decanoic acid and upwards; 4 hour skin corrosivity is considered positive for decanoic acid and lower, negative for lauric acid and higher; eye irritation is considered positive for lauric acid and lower, negative for myristic acid and higher. Among the fatty acid derivatives that have well recognized bacteriocidal and fungicidal properties are undecanoic acid and its salts, sodium and zinc particularly, (athlete’s foot fungus), fatty amine quaternary salts, (general bacteriocide properties), fatty amide derivatives, and sodium salts of common fatty acids. The highly purified monoglyceride prepared from high C-12 fatty acid has unprecedented activity and sanitizing properties.
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References
“Pharmacological Role of Lipids”, Edited by J.J. Kabara, AOCS, Champaign, IL 1979.
Kayden, H.J., J.R. Senior, and F.H. Mattson, J. Clin. Invest 46:(11) 1695 (1967).
Mattson, F.H., and Volpenhein, R.A., J. Biol. Chem. 234:2792 (1964).
Johnston, J.M., Aliment. Canal 3:1353 (1968).
Porter, K.B., Fed. Proc. Sympos 28:35, (1969).
Senior, J.R., J. Lipid Res. 5:495 (1964).
Lehininger, A., “Biochemistry-The Molecular Basis of Cell Structure and Function,” Worth Publ. Inc., New York, 1970.
Florey, E., “An Introduction to General and Comparative Animal Physiology”, W.B. Saunders, Co., Philadelphia, PA, 1966, p. 713.
Buensod, M., and P. Favarger, Helv. Physiol. Pharmacol. Aeta. 14:299 (1956).
Lang, K., and F.B. Schmidt, Z. Ernaehrungswiss 10:111 (1970).
Koppanyi, T., and V.G. Dardin, FDA Food Additive Petition, No. 552, 37, 1973.
Sourkes, T.L., and T. Koppanyi, J. Am. Pharm. Assoc. 39:275.
Farber, L., and A.M. Wynne, Biochem. J. 29:2323 (1935).
Zuckerman, I.C., C.M. Jacobi, B. Kogut, and B. Klein, Am. J. Digest Dis. Nutr. 7:208 (1940).
Pinter, K., I.P. Karle, and J. Hamilton, Fed. Proc. 23:399 (1964).
Frazer, A.C., Fed. Proc. 20:146, 161 (1961).
Issel bacher, K.J., Fed. Proc. Sympos. 26:1420 (1967).
Porter, K.R., Ibid. 28:35 (1969).
Briggs, G.B., R.L. Doyle, and J.A. Young, Am. Ind. Hyg. Assoc. J. April, 251–253 (1976).
Kaunitz, H., in “Pharmacological Effects of Lipids”, Edited by J. Kabara, AOCS, Champaign, IL, 1979.
Braun, W.Q., and C.L. Shrewsburg, Oil Soap 18:249 (1941).
Anonymous, GRAS Food Ingredients-Glycerine and Glycerides, Ordering Number PB-221–227, National Technical Information Service, USD of Commerce, Springfield, VA, 1973.
Eagle, E., and C.E. Poling, Food Res. 21:348 (1956).
Krantz, J.C., Jr., P.J. Culver, C.J. Carr, and C.M. Jones, Bull. School Med. (Univ. of Maryland) 36:48 (1951).
Elworthy, P.H., and J.F. Treon, in “Nonionic Surfactants”, Vol. 1, Edited by M.J. Schick, Marcel Dekker, New York, 1967, p. 923.
Ambrose, M.A., D.J. Robbins, and A.J. Cox, Jr., Food Res. 23:536 (1959).
Solomides, J., Compt Rend Soc de Biol 138:832 (1944).
Hine, C.H., H.H. Anderson, H.D. Moon, M.K. Dunlap, and M.S. Morse, Arch. Indust. Hyg. and Occup. Med. 7:282 (1953).
Li, R.C., P.P.T. Suh, and H.H. Anderson, Proc. Soc. Exp. Biol. Med. 46:26 (1941).
Ambrose, A.M., and D.J. Robbins, J. Am. Pharm., Assoc. Sci. 45:282 (1956).
Hertig, D.C. and R.C. Crain, Proc. Soc. Exp. Biol. Med. 48:347 (1958).
Anon, Food Additive Petition, Number 771.
Wrestlind, A., Acta Physiol. Scand. 40:338 (1957).
Fitzhugh, O.G., A.R. Bourke, A.A. Nelson, and J.P. Frawley, J. Toxicol Appl. Pharmacol 1:315 (1959).
Mattson, F.H., F.J. Baur, and L.W. Beck, JAOCS 28:386 (1951).
Ames, S.R., M.P.O. Grady, N.D. Embree, and P.L. Harris, Ibid. 28:31 (1951).
Braun, W.O., and C.L. Shrewsburg, Oil Soap 18:249 (1941).
Harris, R.S., and H. Sherman, Food Res. 19:257 (1954).
Ambrose, A.M., and D.J. Robbins, J. Am. Pharmacol. Assoc. Sci., 45:282 (1956).
Ambrose, A.M., D.J. Robbins, and A.J. Cox, Food Res. 23:536 (1958).
Mattson, F.H., J.C. Alexander, F.J. Baur, and H.H. Reller, J. Nutr. 59:277 (1956).
Anon, Food Additive, Petition Number 884.
Ibid. Anon, Food Additive, Petition Number 31.
Ibid. Anon, Food Additive, Petition Number 35.
McManus, T.B., C.B. Bender, and O.F., Ganett, J. Dairy Sci. 26:13 (1943).
Orten, J.M., and R.N. Dajan, Food Res. 22:529 (1957).
Krantz, J.C., Jr., P.J. Culver, C.J. Carr, and C.M. Jones, Bull. School Med. (University of Maryland) 36:48 (1951).
Elworthy, P.H., and J.F. Treon in “Nonionic Surfactants”, Vol. 1, Edited by M.J. Schick, Marcel Dekker, New York, 1967, p. 923.
Fitzhugh, O.G., A.R. Bourke, A.A. Nelson, and J.P. Frawley, Toxicol. Appl. Pharmacol. 1:315 (1959).
Chow, B.F., J.M. Burnett, C.T. Ling, and L. Barrows, J. Nutr. 49:563 (1953).
Oser, B.L., and M. Oser, Ibid. 60:489 (1956).
Ibid. 61:149 (1957).
Ibid. 61:253 (1957).
Treon, J.F., L.E. Gongwer, M.F. Nelson, and J.C. Kirschman, Proc. Int. Congr. 4th, 1964, 3:381 (1967).
Culver, P.J., C.S. Wilcox, C.M. Jones, and R.S. Rose, Jr., J. Pharmacol. Exp. Ther. 103:377 (1951).
King, W.R., W.R. Michael, and R.H. Coots, Toxicol. Appl. Pharmacol. 20:327 (1971).
Mitchell, W.R., and R.H. Coots, Ibid. 20:334 (1971).
Babayan, V.K., H. Kaunitz, and C.A. Slanetz, JAOCS 41:434 (1964).
Babayan, V.K., T.G. Kaufman, H. Lehman, and R.J. Traczuk, J. Soc. Cosmet. Chem. 15:473 (1964).
Fisherman, E.W., and G.N. Cohen, Ann. Allerg. 32:307 (1974).
Kabara, J.J., in “Pharmacological Effects of Lipids,” Edited by J.J. Kabara, AOCS Champaign, IL, 1979, p. 11.
Bayliss, M., J. Bacteriol. 31:489 (1936).
Dodicek, E., Soc. Exp. Biol. Symp. 3:217 (1949).
Nieman, C., Bacteriol. Rev. 18:147 (1954).
Chattaway, F.W., C.C. Thompson, and A.J.E. Barlow, Biochem. J. 63:648 (1956).
Glassman, H.M., Bacteriol. Rev. 12:105 (1948).
Prince, H.N., J. Bacteriol. 78:788 (1959).
Stock, C.C., and T. Francis, Jr. J. Exp. Med. 71:661 (1940).
Stock, C.C., and T. Francis, Jr., Ibid. 77:323 (1943).
Stock, C.C., and T. Francis, Jr., J. Immunol. 47:303 (1943).
Ando, E., S. Suzuki, K. Suzuki, K. Kodama, A. Kato, G. Tumura, and K. Arima, J. Antibiot. XXI:690 (1968).
Hotchkiss, R.D., Ann. NY Acad. Sci. 46:479 (1946).
Baker, Z., R.W. Harrison, and B.F. Miller, J. Exp. Med., 74:621 (1941).
Baker, Z., R.W. Harrison, and B.F. Miller, Ibid. 73:249 (1941).
Glassman, H.N., Bacteriol. Rev. 12:105 (1949).
Hawking, F., and J.S. Lawrence, “The Sulphonamides”, Lewis Press, London, 1950.
Lawrence, C.A., “Surface Active Quaternary Ammonium Germicides,” Academic Press, Inc., New York, 1950.
Kabara, J.J., D.M. Swieczkowski, A.J. Conley, and J.P. Truant, Antimicrob. Agents Chemother, 2:23 (1972).
Conley, A.J., and J.J. Kabara, Ibid. 4:501 (1973).
Kabara, J.J., A.J. Conley, and J.P. Truant, Ibid. 2:492 (1972).
Kabara, J.J., R. Vrable, I. Ikeda, and M. Okahara, JAOCS 54:316 (1977).
Kabara, J.J., JAOCS 54:202 (1977).
Ferguson, J., Proc. Roy. Soc. (London), 127B, 387 (1939).
Schwartz, A.M., J.W. Perry, and J. Berch, “Surface Active Agents and Detergents,” R.E. Krieger Publishing Company, Huntington, New York, 1977, p. 230.
Kabara, J.J., R. Vrable, and M. Lie Ken Jie, Lipid 9:753 (1977).
Kabara, J.J., A.J. Conley, D.J. Swieczkowski, I.A. Ismail, M. Lie Ken Jie, and F.D. Gunstone, J. Med. Chem. 16:1060 (1972).
Kabara, J.J., (to Med-Chem Labs, Inc.) U.S. Patent 4067 997, 1978.
Wyss, V., B.J. Ludwig, and R.R. Joiner, Arch. Biochem. 7:415 (1945).
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Kabara, J.J. Toxicological, bacteriocidal and fungicidal properties of fatty acids and some derivatives. J Am Oil Chem Soc 56, 760A–767A (1979). https://doi.org/10.1007/BF02667439
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DOI: https://doi.org/10.1007/BF02667439