Abstract
In this study histologic slides of 165 patients who were diagnosed as RCC between 1983 and 1993 were re-evaluated and each tumour was graded according to Thoenes, Fuhrman, Arner and Skinner's grading systems. According to Thoenes' system, patients with grade (G) 2 and 3 tumours had significantly shorter survival compared to patients with G 1 tumours. The survival difference between the subgroups of Fuhrman and Skinner's grading systems did not reach statistical significance. When the histologic differentiation was grouped as low grade (G 1&2) and high grade (G 3&4) tumours in Fuhrman and Skinner's systems, a statistically significant difference was noted between the groups in terms of survival.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Peterson, R. O.: Kidney. In: Urologic Pathology, 2nd edition. J. B. Lippincott Company, Philadelphia 1992, pp. 50–100.
Thrasher, B., Paulson, F.: Prognostic factors in renal cancer.Urol. Clin. North. Am., 20, 247 (1993).
Thoenes, W., Störkel, S., Rumpelt, H. J.: Histopathology and classification of renal cell tumors (Adenomas, Oncocytomas and Carcinomas). The basic cytological and histopathological elements and their use for diagnostics.Path. Res. Pract., 181, 125 (1986).
Nadasdy, T., Bane, B. L., Silva, F. G.: Adult renal diseases. In: Sternberg, S. (ed.): Diagnostic Surgical Pathology, 2nd edition. Raven Press, New York 1994, pp. 1705–1730.
Strohmeyer, T., Ackermann, R.: Classic and modern prognostic indicators in renal cell carcinoma. Review of the literature.Urol. Int., 47, 203 (1991).
Arner, O., Blanck, C., von Schreeb, T.: Renal adenocarcinoma: Morphology—grading of malignancy—prognosis: A study of 197 cases.Acta Chir. Scand. (Suppl.),346, 11 (1965).
Skinner, D., Colvin, R. B., Vermillion, C. D., Tfister, R. C., Leadbetter, W. F.: Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases.Cancer, 28, 1165 (1971).
Fuhrman, S. A., Lasky, L. C., Limas, C.: Prognostic significance of morphologic parameters in renal cell carcinoma.Am. J. Surg. Pathol., 6, 655 (1982).
Robson, C. J., Churchill, B. M., Anderson, W.: The results of radical nephrectomy for renal cell carcinoma.J. Urol., 101, 297 (1969).
Takashi, M., Nakano, Y., Sakata, T., Miyake, K., Hamajima, N.: Multivariate evaluation of prognostic determinants for renal cell carcinoma.Urol. Int., 50, 6 (1993).
Selli, C., Hinshaw, W. M., Woodard, B. H., Paulson, D. F.: Stratification of risk factors in renal cell carcinoma.Cancer, 52, 899 (1983).
Boxer, R. J., Waisman, J., Lieber, M., Skinner, D. G.: Renal carcinoma: Computer analysis of 96 patients treated by nephrectomy.J. Urol., 122, 598 (1979).
Neves, R. J., Zincke, H., Taylor, W. F.: Metastatic renal cell cancer and radical nephrectomy: Identification of prognostic factor and patient survival.J. Urol., 139, 1173 (1988).
Golimbu, M., Joshi, P., Sperber, A., Tessler, A., Al-Askari, S., Morales, P.: Renal cell carcinoma: Survival and prognostic factors.Urology, 27, 291 (1986).
Gelb, A. B., Shibuya, R. B., Weiss, L. M., Medeiros, L. J.: Stage 1 renal cell carcinoma: A clinicopathologic study of 82 cases.Am. J. Surg. Pathol., 17, 275 (1993).
Tomera, K. M., Farrow, G. M., Lierber, M. M.: Well differentiated (grade 1) clear renal cell carcinoma.J. Urol., 129, 933 (1983).
Naito, S., Kimiya, N., Sakamoto, N., Soejima, T., Ueda, T., Kumazawa, J., Osada, Y., Sagiyama, K., Ariyoshi, A.: Prognostic factors and value of adjunctive nephrectomy in patients with stage 4 renal cell carcinoma.Urology, 37, 95 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Usubütün, A., Uygur, M.C., Ayhan, A. et al. Comparison of grading systems for estimating the prognosis of renal cell carcinoma. International Urology and Nephrology 30, 391–397 (1998). https://doi.org/10.1007/BF02550216
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02550216