Abstract
Six groups of rats were fed diets low, but adequate, in α-tocopherol but high in γ-tocopherol. The six diets differed only in their contents (0, 0.25, 0.5, 1.0, 2.0, and 4.0 g/kg, respectively) of sesamin, a lignan from sesame oil. After four weeks ofad libitum feeding, the rats were sacrificed and the concentrations of α- and γ-tocopherols were measured in the plasma, livers, and lungs. Sesamin-feeding increased γ-tocopherol and γ-/α-tocopherol ratios in the plasma (P<0.05), liver (P<0.001), and lungs (P<0.001). The increase was non-significant for α-tocopherol. Thus, sesamin appears to spare γ-tocopherol in rat plasma and tissues, and this effect persists in the presence of α-tocopherol, a known competitor to γ-tocopherol. This suggests that the bioavailability of γ-tocopherol is enhanced in phenol-containing diets as compared with purified diets.
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Abbreviations
- α-T:
-
α-tocopherol
- γ-T:
-
γ-tocopherol
- GTL:
-
γ-tocopherol levels
- HPLC:
-
high-performance liquid chromatography
- SL:
-
sesamin levels
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Kamal-Eldin, A., Pettersson, D. & Appelqvist, LÅ. Sesamin (a compound from sesame oil) increases tocopherol levels in rats fedad libitum . Lipids 30, 499–505 (1995). https://doi.org/10.1007/BF02537023
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DOI: https://doi.org/10.1007/BF02537023