Summary
Study of the humeral cortex of 89 acute cadavers showed that an important factor contributing to the physiologic bone loss of aging is increasing bone porosity. Mean cortical porosity increases in both sexes with age, from 4.6% in men and 4% in women at 40 years of age to 10% and more at age 80. In the population studied, no significant difference of porosity was observed between men and women. Apparent mineral density is linked to porosity, and decreases markedly with age in women. Changes in men are lesser in magnitude and show a larger difference of density values. Correction of the apparent mineral density, by a factor reflecting the proportion of vascular and resorption spaces in the cortical bone, produces a true mineral density which does not vary significantly with age in either sex. The density values obtained for the proximal humerus differ from those in the literature which represent the femur. However, they are more readily compared with the results of clinical densitometry and may have greater clinical applications.
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References
Garn SM (1970) The earlier gain and the later loss of cortical bone. C. C. Thomas, Springfield
Dequeker J (1980) Measurement of bone mass and bone remodelingin vivo: Value of the radiogrammetric approach. Acta Rhum 4:40–75
Virtama P, Helelä T (1969) Radiographic measurements of cortical bone. Acta Radiol (Suppl 293) Stockholm
Bloom RA (1980) A comparative estimation of the combined cortical thickness of various bone sites. Skeletal Radiol 5:167–170
Bernard J, Laval-Jeantet M (1962) L'épaisseur relative de la corticale du tibia: Application à l'évaluation des ostéoporoses et des ostéoscléroses. Presse Méd 70:889–890
Jowsey J (1960) Age changes in human bone. Clin Orthop 17:210–218
Atkinson PJ (1965) Changes in resorption spaces in femoral cortical bone with age. J Pathol Bact 89:173–178
Martin RB, Pickett JC, Zinaich S (1980) Studies of skeletal remodeling in aging men. Clin Orthop 149:268–282
Laval-Jeantet AM, Goldman S, Laval-Jeantet M (1977) Densitométrie osseuse de précision sur films sans écrans. J Radiol Electrol 58:63–68
Laval-Jeantet AM, Chateau JY, Bergot C, Laval-Jeantet M, Kuntz D (1981) Comparaison de la radiodensitométrie et de l'histomorphométrie dans l'étude de l'os normal et pathologique. Pathol Biol 29:155–161
Bloom RA, Laws JW (1970) Humeral cortical thickness as an index of osteoporosis in women. Br J Radiol 43:522–527
Meunier A, Dallant P, Christel P, Sedel L (1983) A microcomputer laboratory technic to quantify cortical bone microstructure. 29th Annual ORS Anaheim California, March 8–10 1983
Jowsey J (1968) Age and species differences in bone. Cornell Vet 57 (Suppl Jan) 74–94
Currey JD (1964) Some effects of ageing in human haversian systems. J Anat London 98:69–75
Singh M, Gunberg DL (1970) Estimation of age at death in human males from quantitative histology of bone fragments. Am J Phys Anthrop 33:373–382
Thompson DD (1980) Age changes in bone mineralization, cortical thickness, and haversian canal area. Calcif Tissue Int 31:5–11
Atkinson PJ, Weatherell JA (1967) Variation in the density of the femoral diaphysis with age. J Bone Joint Surg 49B:781–788
Bergot C, Bocquet JP (1976) Etude systématique en fonction de l'âge de l'os spongieux et de l'os cortical de l'humérus et du fémur. Bull Mém Soc Anthropol Paris, 3 (Série XIII):215–242
Lindahl O, Lindgren A (1967) Cortical bone in man. I. Variation of the amount and density with age and sex. Acta Orthop Scand 38:133–140
Arnold JS (1970) Focal excessive endosteal resorption in aging and senile osteoporosis. In: Barzel US (ed) Osteoporosis. Grune & Stratton, New York, pp 80–100
Bergot C, Prêteux F, Mark AS, Laval-Jeantet AM, Serra J (1982) Automatic analysis of microradiographs: Porosity of humeral cortical bone during aging. In: Silbermann M, Slavkin HC (eds) Current advances in skeletogenesis. Excerpta Medica, Amsterdam, pp 490–497
Baud CA (1968) Submicroscopic structure and functional aspects of the osteocyte. Clin Orthop 56:227–236
Black J, Mattson RU (1982) Relationship between porosity and mineralization in the haversian osteon. Calcif Tissue Int 34:332–336
Boyde A (1980) Evidence against “osteocytic osteolysis.” In: Jee WSS, Parfitt AM (eds) Bone histomorphometry. Suppl to Metab Bone Dis Rel Res, S.N.P.M.D., Paris, pp 239–255
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Laval-Jeantet, AM., Bergot, C., Carroll, R. et al. Cortical bone senescence and mineral bone density of the humerus. Calcif Tissue Int 35, 268–272 (1983). https://doi.org/10.1007/BF02405044
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DOI: https://doi.org/10.1007/BF02405044