Summary
The concentration ofα 2HS-glycoprotein was measured in the serum and urine of normal individuals and of patients with osteogenesis imperfecta. The serum concentration ofα 2HS-glycoprotein was higher in normal children than in adults. In women values showed a progressive agerelated decrease, from 632 mg/l at 21–30 years to 573 mg/l at 51–60 years. In men there was no such age-related variation, and values were higher than in women of comparable age; the mean value for men aged 20–60 years was 648 mg/l. Of 48 patients with osteogenesis imperfecta, 11 had an abnormally high concentration ofα 2HS-glycoprotein in serum; the cause of this is not clear. In urine of 24 normal individuals the mean value of the ratio albumin:α 2HS-glycoprotein was 20±3; in serum the corresponding ratio was 70. Urine excretion ofα 2HS-glycoprotein was lowest in female children (132±29 µg/24 h) and highest in male adults (592±91 µg/24 h); values in patients with osteogenesis imperfecta did not differ from normal.
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Dickson, I.R., Bagga, M. & Paterson, C.R. Variations in the serum concentration and urine excretion ofα 2HS-glycoprotein, a bone-related protein, in normal individuals and in patients with osteogenesis imperfecta. Calcif Tissue Int 35, 16–20 (1983). https://doi.org/10.1007/BF02405000
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DOI: https://doi.org/10.1007/BF02405000