Abstract
Purpose
To assess cigarette smoking of female patients prior to starting in vitrofertilization cycle and possible affect on subsequent in vitrofertilization-embryo transfer outcome.
Methods
Retrospective study involving 340 consecutive patient questionnaires filled out at time of in vitrofertilization program entry. Only cycles resulting in embryo transfer after transvaginal ultrasound directed ovum retrieval (n=253) were considered. The three patient pregnancy outcomes of not pregnant, spontaneous abortion, and live birth, were cross-referenced with smoking and nonsmoking patients.
Results
No significant difference found in overall pregnancy rate per embryo transfer for smokers (35%) vs nonsmokers (31%). However, the abortion rate was significantly higher for the smokers (73%) vs nonsmokers (24%) with a Pvalue < 0.001.
Conclusions
Results suggest preentry in vitrofertilization cycle cigarette smoking has adverse affect on potential pregnancy outcome by increasing spontaneous abortion. Preconception health consultation concerning adverse cigarette smoking effects should be implemented prior to program entry.
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Maximovich, A., Beyler, S.A. Cigarette smoking at time ofin vitro fertilization cycle initiation has negative effect onin vitro fertilization-embryo transfer success rate. J Assist Reprod Genet 12, 75–77 (1995). https://doi.org/10.1007/BF02211373
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DOI: https://doi.org/10.1007/BF02211373