Abstract
The multidrug resistance P-glycoprotein (P-gp) is an active drug transporter which can expel hydrophobic compounds from cells. Expression of P-gp has many effects on cells and tissues and the physiological function, or functions, of P-gp are still unclear. Recently, expression of P-gp has been associated with altered activity of chloride channels which play a role in regulating cell volume of response to osmotic shock or nutrient uptake. The nature and physiological role of this association has been a subject of some debate. In this article, mechanisms by which P-gp might influence cell volume-activated chloride currents is discussed, and the potential physiological role of this regulation considered.
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Altenbcrg, G. A., Vanoye, C. G., Han, E. S., Deitmer, J. W., and Reuss, L. (1994a).J. Biol. Chem. 269, 7145–7149.
Altenberg, G. A., Deitmer, J. W., Glass, D. C. and Ruess, L. (1994b).Cancer Res. 54, 618–622.
Anderson, M. P., Gregory, R. J., Thompson, S., Souza, D. W., Paul, S., Mulligan, R. C., Smith, A. E., and Welsh, M. J. (1991).Science 253, 202–205.
Ashford, M. L. J., Bond, C. T., Blair, T. A., and Adelman, J. P. (1994).Nature (London) 370, 456–459.
Bear, C. E., Kartner, N., Bridges, R. J., Jensen, T. J., Ramjeesingh, M., and Riordan, J. R. (1992).Cell 68, 809–818.
Breuer, W., Slotki, I. N., Ausiello, D. A., and Cabantchik, I. Z. (1994).Am. J. Physiol. 265, C1711-C1715.
Bryan, J., Aguilar-Bryan, L., Nichols, C., and Nelson, D. (1994). “The high-affinityα/Β-cell sulfonylurea receptor is a novel member of the ATP-binding cassette superfamily,” NIDDK Workshop on the Novel ATPases and Disease, Lister Hill Auditorium, USA.
Chambers, T. C., Pohl, J., Raynor, R. L., and Kuo, J. F. (1993).J. Biol. Chem. 268, 4592–4595.
Chang, X-B., Tabcharani, J. A., Hou, Y-X., Jensen, T. J., Kartner, N., Alon, Hanrahan, J. W., and Riordan, J. R. (1993).J. Biol. Chem. 268, 11304–11311.
Cheng, S. H., Rich, D. P., Marshall, J., Gregory, R. J., Welsh, M. J., and Smith, A. E. (1991).Cell 66, 1027–1036.
Diaz, M., Valverde, M. A., Higgins, C. F., Racareanu, C., and Sepulveda, F. V. (1993).Eur. J. Physiol. 422, 347–353.
Dong, Y., Chen, C., Duran, G. E., Kouyama, K., Chao, A. C., Sikic, B. I., Gollapudi, S. V., Gupta, S., and Gardner, P. (1994).Cander Res. 54, 5029–5032.
Egan, M., Flotte, T., Afione, S., Solow, R., Zeitlin, P. L., Carter, B. J., and Guggino, W. B. (1993).Nature (London) 358, 581–584.
Gabriel, S. E., Clarke, L. L., Boucher, R. C., and Stutts, M. J. (1993).Nature (London) 363, 263–266.
Gill, D. R., Hyde, S. C., Higgins, C. F., Valverdc, M. A., Mintenig, G. M., and Sepulveda, F. V. (1992).Cell 71, 23–32.
Gottesman, M. M., and Pastan, I. (1993).Annu. Rev. Biochim. 62, 385–427.
Grunder, S., Thieman, A., Pusch, M., and Jentsch, T. J. (1992).Nature, (London),360, 759–762.
Han, E. S., Vanoye-Trevino, C. Altenberg, G. A., and Reuss, L. (1995). “Different properties of swelling activated Cl− currents in P-glycoprotein (Pgp) expressing and control cells,” Biological Society (abstract).
Hardy, S. P., Goodfellow, H. R., Valverde, M. A., Gill, D. R., Sepulveda, F. V., and Higgins, C. F. (1995).EMBO J. 14, 101–108.
Higgins, C. F. (1992).Annu. Rev. Cell Biol. 8, 67–113.
Hoffmann, E. K., and Simonsen, L. O. (1989).Physiol. Rev. 69, 315–382.
Hyde, S. C., Emsley, P., Hartshorn, M. J., Mimmack, M. M., Gileadi, U., Pearce, S. R., Gallagher, M. P., Gill, D. R., Hubbard, R. E., and Higgins, C. F. (1990).Nature (London) 346, 362–365.
Jirsch, J., Deeley, R. G., Cole, S. P. C., Stewart, A. J., and Fedida, D. (1993).Cancer Res. 53, 4156–4160.
Jirsch, J. D., Loe, D. W., Cole, S. P. C., Deeley, R. G., and Fedida, D. (1994).Am. J. Physiol. 267, C688-C699.
Krapivinsky, G. B., Ackerman, M. J., Gordon, E. A., Krapivinsky, L. D., and Clapham, D. E. (1994).Cell 76, 439–448.
Luckie, B., Krouse, M. E., Harper, K. L., Law, T. C., and Wine, J. J. (1984).Am. J. Physiol. 267, C650-C658.
McEwan, G. T. A., Hunter, J., Hirst, B. H., and Simmons, N. L. (1992).FEBS Lett. 304, 233–236.
Mintenig, G. M., Valverde, M. A., Sepulveda, F. V., Gill, D. R., Hyde, S. C., Kirk, J., and Higgins, C. F. (1993).Receptors and Channels 1, 305–313.
Nilius, B., Sehrer, J., and Droogmans, G. (1994).Br. J. Pharmacol. 112, 1049–1056.
Orr, G. A., Han, E. K.-H., Browne, P. C., Nieves, E., O'Connor, B. M., Yang, C-P. H., and Horwitz, S. B. (1993).J. Biol. Chem. 268, 25054–25062.
Parra-Lopez, C., Lin, R., Aspedon, A., and Groisman, E. A. (1994).EMBO J. 13, 3964–3972.
Paulmichl, P., Li, Y., Wickman, K., Ackerman, M., Peralta, E., and Clapham, D. (1992).Nature (London) 356, 238–241.
Rasola, A., Galietta, L. J. V., Gruenert, D. C. and Romeo, G. (1994).J. Biol. Chem. 269, 1432–1436.
Rich, D. P., Gregory, R. J., Anderson, M. P., Manavalan, P., Smith, A. E., and Welsh, M. J. (1991).Science 253, 205–207.
Sardini, A., Mintenig, G. M., Valverde, M. A., Sepulveda, F. V., Gill, D. R., Hyde, S. C. Higgins, C. F., and McNaughton, P. A. (1994).J. Cell Sci. 107, in press.
Sarkadi, B., and Parker, J. C. (1991).Biochim. Acta 1071, 407–427.
Sole, C. K., and Wine, J. J. (1991).Am. J. Physiol. 261, C658-C674.
Thiemann, A., Grunder, S., Pusch, M., and Jentsch, T. J. (1992).Nature (London) 356, 57–60.
Trezise, A. E. O., Romano, P. R., Gill, D. R., Hyde, S. C., Sepulveda, F. V., Buchwald, M., and Higgins, C. F. (1992).EMBO J. 11, 4291–4303.
Valverde, M. A., Diaz, M., Sepulveda, F. V., Gill, D. R., Hyde, S. C., and Higgins, C. F. (1992).Nature (London),355, 830–833.
Valverde, M. A., Mintenig, G. M. and Sepulveda, F. V. (1993).Eur. J. Physiol. 425, 552–554.
Wang, X., Wall, D. M., Parkin, J. D., Zalcberg, J. R., and Kemm, R. P. (1994).Clin. Exp. Pharmacol. Physiol. 21, 101–108.
Zhang, J. J., and Jacob, T. J. C. (1994).Am. J. Physiol., in press.
Zhang, J. J., Jacob, T. J. C., Valverde, M. A., Hardy, S. P., Mintenig, G. M., Sepulveda, F. V., Gill, D. R., Hyde, S. C., Trezise, A. E. O., and Higgins, C. F. (1994).J. Clin. Invest. 94, 1690–1697.
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Higgins, C.F. P-glycoprotein and cell volume-activated chloride channels. J Bioenerg Biomembr 27, 63–70 (1995). https://doi.org/10.1007/BF02110332
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DOI: https://doi.org/10.1007/BF02110332