Abstract
Abstract
Three short prepubertal children with X-linked hypophosphataemia were treated with 1 IU recombinant human growth hormone (rhGH)/kg per weck sc in addition to calcitriol and phosphate supplementation over a period of 3 years. Improvement of height standard deviation score (SDS) ranged from 1.0–1.7 SD based on an increase in sitting height of 1.5–2.9 SD, whereas subischial leg length improved only slightly by 0.3–0.9 SD. In all three patients, renal phosphate threshold concentration increased slightly and transient hyperparathyroidism was noted.
Conclusion
Treatment of stunted children with X-linked hypophosphataemia is effective in improving growth velocity, but appears to aggravate the pre-existent disporportionate stature of such children.
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Abbreviations
- GFR :
-
glomerular filtration rate
- GH :
-
growth hormone
- rhGH :
-
recombinant human growth hormone
- TmP/GFR :
-
renal threshold phosphate concentration
- XLH :
-
X-linked hypophosphataemia
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Haffner, D., Wühl, E., Blum, W.F. et al. Disproportionate growth following long-term growth hormone treatment in short children with X-linked hypophosphataemia. Eur J Pediatr 154, 610–613 (1995). https://doi.org/10.1007/BF02079060
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DOI: https://doi.org/10.1007/BF02079060