Abstract
A most compelling stimulus to investigate the influence of actively-induced immunity in experimental coccidioidomycosis is found in the epidemiologic studies ofSmith (35) andSmith et al. (37–39). Their serologic and skin test surveys among residents in areas of coccidioidal endemicity directed attention to a role apparently played by actively-acquired immunity in man exposed toCoccidioides immitis. It was found that after recovery from illness, or after the acquisition of dermal sensitivity to coccidioidin in the absence of manifest illness, there was very little likelihood of a second symptomatic coccidioidal episode.Smith (personal communication) inferred from the above observation thatC. immitis was endowed with effective immunogens and speculated (37) that live or killed coccidioidal vaccines could be of profound public health significance. During the two decades following the report ofSmith et al. (39) on the use of coccidioidin, workers explored the efficacies and advantages of live and killed vaccines in experimentally produced coccidioidomycosis in animals.
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This work was sponsored by the Office of Naval Research, the Bureau of Medicine and Surgery, United States Navy and the Armed Forces Epidemiological Board, Commission on Acute Respiratory Diseases, under contracts with the Regents of the University of California. Reproduction in whole or in part is permitted for any purpose of the United States Government.
Paper read at the Eighth International Congresses for Tropical Medicine and Malaria, September 1968, Teheran (Iran).
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Levine, H.B., Pappagianis, D. & Cobb, J.M. Development of vaccines for coccidioidomycosis. Mycopathologia et Mycologia Applicata 41, 177–185 (1970). https://doi.org/10.1007/BF02051493
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DOI: https://doi.org/10.1007/BF02051493