Abstract
Carrageenan-induced hind paw oedema has been studied in rats deprived of copper for different lengths of time.
A common feature observed in normally fed and copper-deficient rats was the rise of serum copper levels coccurring between 10 and 24 h after the injection of the irritant.
After 1 month of copper-deficient diet no differences are seen in the oedema developed by controls and copperdeprived animals, while after 3 months the oedema developed by copper-deficient rats was significantly greater compared with the controls.
These results are briefly discussed.
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Milanino, R., Mazzoli, S., Passarella, E. et al. Carrageenan oedema in copper-deficient rats. Agents and Actions 8, 618–622 (1978). https://doi.org/10.1007/BF01998891
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DOI: https://doi.org/10.1007/BF01998891