Abstract
An inverse correlation was found between the serum aspirin esterase activity in human subjects and the biological half-life of salicylic acid in serum and a direct relationship between the values of the elimination rate constant and the activity of this enzyme. The rate of acetylsalicylic acid breakdown may be one of the factors which influences the biological half-like of salicylates in the organism and may participate also in determining the individual response to the administered drug.
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R.K.S. Lim, F. Guzman, D.W. Rodgers, K. Goto, C. Braun, G.D. Dickerson andR.J. Engle,Site of Action of Narcotic and Non-Narcotic Analgesics Determined by Blocking Bradykinin Evoked Visceral Pain, Arch. int. Pharmacodyn.152, 25–32 (1964).
R. Menguy, L. Desbaillets, S. Okabe andY.F. Masters,Abnormal Aspirin Metabolism in Patients with Cirrhosis and its Possible Relationship to Bleeding in Cirrhotics, Ann. Surg.176, 412–418 (1972).
R. Menguy, L. Desbaillets, Y.F. Masters andS. Okabe,Evidence for a Sex-Linked Difference in Aspirin Metabolism, Nature239, 102–103 (1972).
M. Rowland, S. Riegelman, Ph.A. Harris andS.D. Sholkoff,Absorption Kinetics of Aspirin in Man Following Oral Administration of an Aqueous Solution, J. Pharm. Sci.61, 379–385 (1972).
A. Windorfer, W. Kuenzer andR. Urbanek,The Influence of Age on the Activity of Acetylsalicylic Acid-Esterase and Protein-Salicylate Binding, Eur. J. clin. Pharmac.7, 227–231 (1974).
B.B. Brodie, S. Udenfriend andA.F. Coburn,The Determination of Salicylic Acid in Plasma, J. Pharmac. exp. Ther.80, 114–117 (1994).
J.R. Leonards,Presence of Acetylsalicylic Acid in Plasma Following Oral Ingestion of Aspirin, Proc. Soc. exp. Biol. Med.110, 304–308 (1962).
G. Levy andL.E. Hollister,Variation in Rate of Salicylate Elimination by Humans, Br. med. J.2, 286–288 (1964).
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Trnavský, K., Zachar, M. Correlation of serum aspirin esterase activity and half-life of Salicylic acid. Agents and Actions 5, 549–552 (1975). https://doi.org/10.1007/BF01972693
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DOI: https://doi.org/10.1007/BF01972693