Abstract
The encapsulated form of hepatocellular carcinoma (HCC) is a pathologic subtype that has been found to occur with variable frequency in typical HCC in Japanese radiological, surgical, and autopsy series. It is a well-differentiated tumor that tends to grow slowly and noninvasively, and has a better prognosis than other gross forms of HCC.
Among the 73 cases of typical HCC in patients of non-Asian extraction in our files, 11 could be positively identified as encapsulated based on strict pathological criteria. The purpose of this study was to review the radiographic appearance of these encapsulated tumors.
Radiographically, the tumors demonstrated a hyperdense rim in 5 of 9 cases with postinfusion computed tomography scans, an anechoic halo in 4 of 6 cases with ultrasonograms, and an avascular rim on the capillary phase in 5 of the 8 cases with angiograms.
Encapsulated HCC can be found in non-Asian patients, and the radiographic and pathologic findings are similar to the descriptions in the Japanese series.
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Edmondson HA, Steiner PE: Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies.Cancer 7:462–503, 1954
Okuda K, Ohtsuki T, Obata H, et al: Natural history of hepatocellular carcinoma and prognosis in relation to treatment: study of 850 patients.Cancer 56:918–928, 1985
Nakashima T, Kojiro M, Sakamoto K, et al: Studies of primary liver carcinoma. I. Proposal of new gross anatomical classification of primary liver cell carcinoma.Acta Hepatol Jpn 15:219–291, 1974
Shimokawa Y, Kubo Y, Arishima T, et al: Studies of primary liver carcinoma. III. Clinicopathological characteristics of gross anatomy of hepatocellular carcinoma according to the Nakashima-Okuda classification.Acta Hepatol Jpn 16:752–762, 1975
Okuda K, Obata H, Shigenobu J, et al: Angiographic assessment of gross anatomy of hepatocellular carcinoma: comparison of celiac angiograms and liver pathology in 100 cases.Radiology 123:21–29, 1977
Okuda K, Musha H, Nakajima J, et al: Clinicopathologic features of encapsulated hepatocellular carcinoma: a study of 26 cases.Cancer 40:1240–1245, 1977
Itoh K, Nishimura K, Togashi K, et al: Hepatocellular carcinoma: MR imaging.Radiology 164:21–25, 1987
Ebara M, Ohto M, Watanabe Y, et al: Diagnosis of small hepatocellular carcinoma: correlation of MR imaging and tumor histologic studies.Radiology 159:371–377, 1986
Itai Y, Furui S, Ohtomo K, et al: Dynamic CT features of arterioportal shunts in hepatocellular carcinoma.AJR 146:723–727, 1986
Rummeny E, Weissleder R, Stark DD, et al: Primary liver tumors: diagnosis by MR imaging.AJR 152:63–72, 1986
Tanaka N, Okamot E, Toyosaka A, et al: Pathological evaluation of hepatic dearterialization in encapsulated hepatocellular carcinoma.J Surg Oncol 29:256–260, 1985
Maramatus Y, Takayasu K, Moriyama N, et al: Peripheral low-density area of hepatic tumors: CT-pathologic correlation.Radiology 160:49–52, 1986
Burgener FA, Hamlin DJ: Contrast enhancement of focal hepatic lesions on CT: effect of size and histology.AJR 140:297–301, 1983
Tanaka S, Kitamura T, Imaoka S, et al: Hepatocellular carcinoma: sonographic and histologic correlation.AJR 140:297–301, 1983
Marchal GJ, Pylyser K, Tshibwabwa-Tumba EA, et al: Anechoic halo in solid liver tumors: sonographic, microangiographic and histologic correlation.Radiology 156:479–483, 1985
Takayasu K, Shima T, Muramatsu Y, et al: Angiography of small hepatocellular carcinomas: analysis of 105 resected tumors.AJR 147:525–529, 1986
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The opinion and assertions contained herein are the private views of the authors, and are not to be construed as official or reflective of the views of the Department of the Army, the Department of the Navy, or the Department of Defense.
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Ros, P.R., Murphy, B.J., Buck, J.L. et al. Encapsulated hepatocellular carcinoma: Radiologic findings and pathologic correlation. Gastrointest Radiol 15, 233–237 (1990). https://doi.org/10.1007/BF01888783
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DOI: https://doi.org/10.1007/BF01888783