Abstract
Chitin synthase activity in total membrane fractions from two polyene-resistant, ergosterol-deficient mutants ofCandida albicans was significantly higher in comparison to the parental polyene-sensitive strain. The zymogen component from membrane preparations of stationaryphase cells of ergosterol mutants was more susceptible to trypsin digestion than those from the parental polyene-sensitive strain. Mechanisms that might explain the effect of changes in membrane composition in the mutant strains on chitin synthase activity are discussed.
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Pesti, M., Campbell, J.M. & Peberdy, J.F. Alteration of ergosterol content and chitin synthase activity inCandida albicans . Current Microbiology 5, 187–190 (1981). https://doi.org/10.1007/BF01578527
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DOI: https://doi.org/10.1007/BF01578527