Summary
In the outbreak of abortions, premature births, stillbirths and congenital arthrogryposis-hydranencephaly (AH) syndrome in Japan during the summer through winter of 1972–73 and 1973–74, precolostral sera from calves with congenital AH syndrome and normal calves were tested for neutralizing antibodies against some arboviruses,i. e. Akabane, Aino, Getah and Japanese encephalitis (JE) viruses. The incidence of antibody for Akabane virus was very high in calves with AH syndrome (49/59 or 83 per cent) as compared with normal calves (3/11 or 27 per cent), indicating an intimate correlation between the AH syndrome and precolostral anti-Akabane antibody. Three stillborn fetuses also had anti-Akabane antibody. On the other hand, no precolostral serum antibody for the other viruses was detected in any of the calves tested. The mothers of these calves, normal and with AH syndrome, had anti-Akabane antibody in high percentages (44/52 or 85 per cent and 7/8 or 88 per cent), whereas a few of the mothers had antibodies for the other viruses.
Serological surveys indicate a wide dissemination of Akabane virus in epizootic areas during the summer months of 1972 and 1973. Thus, 8 groups of cattle in epizootic areas showed high rates of seroconversion for Akabane virus during the 1972 or 1973 summer. Very high incidences of Akabane antibody were shown among cattle in epizootic areas but extremely low incidences in near-by non-epizootic areas. The geographic distribution of anti-Akabane antibody among cattle throughout the country in the 1973 spring generally agrees with the pattern of case distribution in the 1972–73 outbreak.
All these findings strongly suggest that Akabane virus is the etiological agent of the outbreaks. Further studies are needed, particularly isolation of the virus, demonstration of infection with the virus in lesions by immunofluorescence and production of intrauterine infection by experimental infection of pregnant cows.
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References
Blood, D. C.: Arthrogryposis and hydranencephaly in newborn calves. Aust. vet. J.32, 25–131 (1956).
Brambell, F. W. R.: The Transmission of passive Immunity from Mother to Young. Amsterdam — London: North-Holland Publ. Co., 1970.
Doherty, R. L., J. G. Carley, H. A. Standfast, A. L. Dyce, andW. A. Snowdon: Virus strains isolated from arthropods during an epizootic of bovine ephemeral fever in Queensland. Aust. vet. J.48, 81–86 (1972).
Doherty, R. L., T. D. St. George, andJ. G. Carley: Arbovirus infections of sentinel cattle in Australia and New Guinea. Aust. vet. J.49, 574–579 (1973).
Dunne, H. W., S. M. Ajinkya, G. R. Bubash, andL. C. Griel: Parainfluenza-3 and bovine enteroviruses as possible important causative factors in bovine abortion. Amer. J. vet. Res.34, 1121–1126 (1973).
Hamana, K., H. Otsuka, Y. Kaseda, D. Nasaka, M. Usui, andM. Hataya: Outbreaks of abortion-arthrogryposis-hydranencephaly syndrome in cattle in Japan, 1972/73. II. Clinical findings of defective calves. Bull. Miyazaki Univ. Agricul. Faculty20, 293–310 (1973). (In Japanese.)
Hataya, M.: Prevalence of obstetrical anomaly among cattle. II. Clinical aspects of abnormal births prevailing among cattle. J. Japan. vet. med. Ass.26, 503–510 (1973). (In Japanese.)
Hartley, W. J., andR. A. Wanner: Bovine congenital arthrogryposis in New South Wales. Aust. vet. J.50, 185–188 (1974).
Horner, G. W., R. H. Johnson, D. P. Dennett, andW. R. Lane: A serological study of bovine fetal immunoglobulins. Aust. vet. J.49, 325–329 (1973).
Hubbert, W. T., J. H. Bryner, A. L. Fernelius, G. H. Frank, andP. C. Estes: Viral infection of the bovine fetus and its environment. Arch. ges. Virusforsch.41, 86–98 (1973).
Inui, S., andY. Maruyama: Pathological studies on the skull and central nervous system of calves in congenital malformation (hydrocephalus and anencephaly). Bull. nat. Inst. Anim. Hlth55, 63–73 (1967). (In Japanese.)
Ishihara, T.: Prevalence of obstetrical anomaly among cattle. I. Epizootiology of abnormal births prevailing among cattle in Japan. State of occurrence in the Kyushu region. J. Japan. vet. med. Ass.26, 491–496 (1973). (In Japanese.)
Kahrs, R. F., F. W. Scott, andA. de Lahunta: Bovine viral diarrhea-mucosal disease, abortion and congenital cerebellar hypoplasia in a dairy herd. J. Amer. vet. med. Ass.156, 851–856 (1970).
Kahrs, R. F., F. W. Scott, andA. de Lahunta: Congenital cellebellar hypoplasia and ocular defects in calves following bovine viral diarrhea-mucosal disease infection in pregnant cattle. J. Amer. vet. med. Ass.156, 1443–1450 (1970).
Kniazeff, A. J., V. Rimer, andL. Gaeta: γ-Globulin in foetal bovine sera: Significance in virology. Nature (Lond.)214, 805–806 (1967).
Konno, S.: Prevalence of obstetrical anomaly among cattle. IV. Pathological aspects of abnormal births prevailing among cattle. J. Japan. vet. med. Ass.26, 515–521 (1973). (In Japanese.)
Markusfeld, O., andE. Mayer: An arthrogryposis and hydranencephaly syndrome in calves in Israel, 1969/70. Epidemiological and clinical aspects. Refuah vet.28, 51–61 (1971).
Matsuyama, T., T. Nakamura, K. Isahai, A. Oya, andM. Kobayashi: Haruna virus, a Group A arbovirus isolated from swine in Japan. Virus18, 11–14 (1968).
McKercher, D. G., J. K. Saito, andK. V. Singh: Serological evidence of an etiologic role for bluetongue virus in hydranencephaly of calves. J. Amer. vet. med. Ass.156, 1044–1047 (1970).
Miura, Y., S. Hayashi, T. Ishihara, Y. Inaba, T. Omori, andM. Matsumoto: Neutralizing antibody against Akabane virus in precolostral sera from calves with congenital arthrogryposis-hydranencephaly syndrome. Arch. ges. Virusforsch. (In Press.)
Nobel, T. A., U. Klopfer, andF. Neuman: Pathology of an arthrogryposis-hydranencephaly syndrome in domestic ruminants in Israel, 1969/70. Refuah vet.28, 144–151 (1971).
Nosaka, D., S. Tateyama, H. Ashizawa, N. Nakamura, H. Yago, T. Shimizu, andT. Murakami: Outbreaks of abortion-arthrogryposis-hydranencephaly syndrome in cattle in Japan, 1972/73. III. Pathological findings of defective calves. Bull. Miyazaki Univ. Agricul. Faculty20, 311–344 (1973). (In Japanese.)
Ohashi, Y.: Prevalence of obstetrical anomaly among cattle. I. Epizootiology of abnormal births prevailing among cattle in Japan. State of occurrence all over the country. J. Japan. vet. med. Ass.26, 487–490 (1973). (In Japanese.)
Omori, T.: Prevalence of obstetrical anomaly among cattle. III. Etiological aspects of abnormal births prevailing among cattle. J. Japan vet. med. Ass.26, 510–515 (1973). (In Japanese.)
Otsuka, H., K. Hamana, M. Hataya, K. Ohira, andY. Matsukata: Outbreaks of abortion-arthrogryposis-hydranencephaly syndrome in cattle in Japan, 1972/73. I. Incidence in Miyazaki Prefecture. Bull. Miyazaki Univ. Agricul. Faculty20, 273–291 (1973). (In Japanese.)
Oya, A., T. Okuno, T. Ogata, I. Kobayashi, andT. Matsuyama: Akabane virus, a new arbor virus isolated in Japan. Jap. J. med. Sci. Biol.14, 101–108 (1961).
Schultz, R. D.: Developmental aspects of fetal bovine immune response. Review. Cornell Vet.63, 507–535 (1973).
Schultz, R. D., H. W. Dunne, andC. E. Heist: Ontogeny of the bovine immune response. Infect. Immun.7, 981–991 (1973).
Solomon, J. B.: Foetal and Neonatal Immunology. Amsterdam — London: North-Holland Publ. Co., 1971.
Takahashi, K., A. Oya, T. Okada, R. Matsuo, M. Kuma, andH. Noguchi: Aino virus, a new member of Simbu group of arboviruses from mosquitoes in Japan. Jap. J. med. Sci. Biol.21, 95–101 (1968).
Watanabe, Y., K. Kisu, R. Iwata, andA. Shimotoku: Prevalence of obstetrical anomaly among cattle. I. Epizootiology of abnormal births prevailing among cattle in Japan. State of occurrence in Chiba Prefecture. J. Japan vet. med. Ass.26, 499–503 (1973). (In Japanese.)
Whittem, J. H.: Congenital abnormalities in calves, arthrogryposis and hydranencephaly. J. Path. Bact.73, 375–387 (1957).
Young, J. S.: Ephemeral fever and congenital deformation in calves. Aust. vet. J.45, 574–576 (1969).
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Kurogi, H., Inaba, Y., Goto, Y. et al. Serologic evidence for etiologic role of Akabane virus in epizootic abortion-arthrogryposis-hydranencephaly in cattle in Japan, 1972–1974. Archives of Virology 47, 71–83 (1975). https://doi.org/10.1007/BF01315594
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DOI: https://doi.org/10.1007/BF01315594