Abstract
Follicle-stimulating hormone (FSH) was used in high doses (6 ampoules/day:6FSH) for ovarian hyperstimulation for in vitro fertilization in women with a previous voor response to stimulation with the equivalent of “4FSH.” Luteinizing hormone levels did not differ between stimulations, but both FSH and estradiol levels were higher in the 6FSH compared to the 4FSH cycle. There were fewer cancellations in the 6FSH cycle, but similar numbers of preovulatory oocytes were retrieved, fertilized, and transferred. The pregnancy rates per attempt and retrieval were higher in the 6FSH cycle. We conclude that raising and maintaining FSH levels during stimulation in low responders reduced cancellations and may improve in vitro fertilization outcome.
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Garcia JE, Jones GS, Acosta AA, Wright G Jr: Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration: Phase II, 1981. Fertil Steril 1983:39:174–179
Rosenwaks Z, Muasher SJ: Recruitment of fertilizable eggs.In In Vitro Fertilization, HW Jones, Jr, GS Jones, GD Hodgen, Z Rosenwaks (eds) Baltimore, Williams and Wilkins, 1986, pp 30–51
Jones GS, Muasher SJ, Rosenwaks Z, Acosta AA, Liu H-C: The perimenopausal patient in vitro fertilization: The use of gonadotropin-releasing hormone. Fertil Steril 1980;46:885–891
de Ziegler D, Cedars MI, Randle D, Lu JKH, Judd HL, Meldrum DR: Suppression of the ovary using a gonadotropin-releasing hormone agonist prior to stimulation for oocyte retrieval. Fertil Steril 1987;48:807–810
Serafini P, Stone B, Kerin J, Batzofin J, Quinn P, Marrs RP: An alternate approach to controlled ovarian hyperstimulation in “poor responders”: Pretreatment with a gonadotropin-releasing hormone analog. Fertil Steril 1988;49:90–95
Awadalla SG, Friedman CI, Chin NW, Dodds W, Park JM, Kim MH: Follicular stimulation for in vitro fertilization using pituitary suppression and human menopausal gonadotropins. Fertil Steril 1987;48:811–815
Muasher SJ, Oehninger S, Simonetti S, Matta J, Ellis LM, Liu HC, Jones GS, Rosenwaks Z: The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril 1988;50:298–307
Jones GS: Use of purified gonadotropins for ovarian stimulation in IVF. Clin Obstet Gynecol 1985;12:775–784
Rosenwaks Z, Muasher SJ, Acosta AA: Use of hMG and/or FSH for multiple follicle development. Clin Obstet Gynecol 1986;29:148–157
Muasher SJ, Garcia JE, Rosenwaks Z: The combination of follicle-stimulating hormone and human menopausal gonadotropin for the induction of multiple follicular maturation for in vitro fertilization. Fertil Steril 1985;44:62–69
Veeck LL, Wortham JWE, Jr, Witmeyer J, Sandow BA, Acosta AA, Garcia JE, Jones GS, Jones HW, Jr: Maturation and fertilization of morphologically immature human oocytes in a program of in vitro fertilization. Fertil Steril 1983;39:594–602
Jones HW, Jr, Acosta AA, Andrews MC, Garcia JE, Jones GS, Mayer J, McDowell JS, Rosenwaks Z, Sandow BA, Veeck LL, Wilkes CA: Three years of in vitro fertilization at Norfolk. Fertil Steril 1984;42:826–834
Jones GS: Update on in vitro fertilization. Endocrine Rev 1984;5:62–75
Metcalf MG, Livesey JH: Gonadotrophin excretion in fertile women: Effect of age and the onset of the menopausal transition. J Endocrinol 1985;105:357–361
Benadiva CA, Ben-Rafeal Z, Strauss JF, III, Mastroianni L, Jr, Flickinger GL: Ovarian response of individuals to different doses of human menopausal gonadotropin. Fertil Steril 1988;49:997–1001
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Hofmann, G.E., Toner, J.P., Muasher, S.J. et al. High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization. J Assist Reprod Genet 6, 285–289 (1989). https://doi.org/10.1007/BF01139183
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DOI: https://doi.org/10.1007/BF01139183