Abstract
Estrogen (E2) and plasma progesterone (P4) levels are valuable parameters for follicular development in in vitro fertilization (IVF) cycles. Furthermore, the progesterone concentration prior to, during, and following human chorionic gonadotropin (hCG) administration is an important marker for the detection of early luteinization and premature ovulation. The pattern of hormonal profile in relation to the number of oocytes retrieved, fertilized, and cleaved and the fate of the pregnancies achieved were compared in three groups of patients treated by the same protocol. Group I included 22 women who conceived with high progesterone levels on day hCG+1 (P4'>2.5 ng/ml). Group II included 43 women who conceived with low P4 values (P4'<2.5 ng/ml), while group III included 46 patients in whom no pregnancies occurred. A significant decrease in fertilization, cleavage, and pregnancy rates was observed in patients with high progesterone levels on day hCG+1, compared to those with normal levels. Nevertheless, it is suggested that cycles with high P4 levels in the preovulatory phase should not be canceled, as a fair chance for pregnancy still exists.
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Laufer N, DeCherney AH, Haseltine FP et al. Steroid secretion by human egg-corona-cumulus complex in culture. J Clin Endocrinol Metabol 1984;58:1153–1157
Laufer N, DeCherney AH, Haseltine FP, et al.: The use of high-dose human menopausal gonadotropin in an in-vitro fertilization program. Fertil Steril 1984;40:734–741
Taylor PJ, Trounson A, Besanko M, et al.: Plasma progesterone and prolactin changes in superovulated women before during and immediately after laparoscopy for in vitro fertilization and their relation to pregnancy. Fertil Steril 1986;45:680–686
Dlugi A, Laufer N, DeCherney AH, et al.: The periovulatory and luteal phase of conception cycles following in vitro fertilization and embryo transfer. Fertil Steril 1984;41:530–537
Cedard L, Guichard A, Janssens Y, et al.: Progesterone and estradiol in saliva after in-vitro fertilization and embryo transfer. Fertil Steril 1987;42:278–283
Stanger JD, Yovich JM, Tuvic AI, et al.: Hormonal profiles in the follicular phase, luteal phase and first trimester of pregnancies arising from in vitro fertilization. Br J Obstet Gynecol 1985;92:374–384
Stanger JD, Yovich JM: Reduced in vitro fertilization of human oocytes from patients with raised basal luteinizing hormone levels during the follicular phase. Br J Obstet Gynecol 1985;92:385–393
Carson RS, Trounson AO, Findlay JK: Successful fertilization of human oocytes in vitro: concentration of 17 beta estradiol, progesterone and androstenedione in the antral fluid of donor follicles. J Clin Endocrinol Metab 1982;55:798–800
Trounson AO, Calabrese R: Changes in plasma progesterone concentration around the time of luteinizing hormone surge in women superovulated for in vitro fertilization. J Clin Endocrinol Metab 1984;59:1075–1080
Jones HW, Jones GS, Andrews MC, et al.: The program for in vitro fertilization in Norfolk. Fertil Steril 1982;38:14–21
Forman R, Fries N, Testart J, et al.: Evidence for an adverse effect of elevated serum estradiol concentration on embryo implantation. Fertil Steril 1988;49:118–122
Speroff L, Glass RH, Kase NG: Clinical Gynecolgic Endocrinology & Infertility, 3rd ed. Baltimore, Williams & Wilkins, 1982, pp 535–541
Katz M: Polycystic ovaries. Clin Obstet Gynecol 1981;8: 715–731.
Tyler J, Collins W: The effect of progesterone and estradiol on gonadotrophin induced oocyte maturation in isolated ovarian follicles from mice. Gamete Res 1980;3:59–64
Smith DM, Tenney D: Effects of steroids on mouse oocyte maturation in vitro. J Reprod Fertil 1980;60:331–338
Moor RM, Polge C, Nillandsen S: Effects of follicular steroids on the maturation and fertilization of mammalian oocytes. J Exp Embryol Morphol 1980;56:319–335
Martel D, Frydman R, Glissant M, Maggioni C, Roche D, Psychoyos A: Scanning electron microscopy of postovulatory human endometrium in spontaneous and stimulated cycles. J Endocrinol 1987;114:319–324
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Feldberg, D., Goldman, G.A., Ashkenazi, J. et al. The impact of high progesterone levels in the follicular phase of in vitro fertilization (IVF) cycles: A comparative study. J Assist Reprod Genet 6, 11–14 (1989). https://doi.org/10.1007/BF01134575
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DOI: https://doi.org/10.1007/BF01134575