Abstract
A mathematical model was developed to analyze the elimination kinetics of drug interactions in the rat. The model is based on physiological blood flow rates and organ weights and includes Michaelis-Menten equations for enzymatic processes which are involved in the elimination of the drug;competitive inhibition interactions are computed for shared pathways. Using data from the single drugs, the model can simulate the results of experiments of the acute warfarin-BSP interactions in rats.
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This work was supported in part by Grant HL15698 from the USPHS.
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Luecke, R.H., Wosilait, W.D. Drug elimination interactions: Analysis using a mathematical model. Journal of Pharmacokinetics and Biopharmaceutics 7, 629–641 (1979). https://doi.org/10.1007/BF01061211
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DOI: https://doi.org/10.1007/BF01061211