Abstract
Following oral administration to human subjects, isonicotinuric acid was hydrolyzed within the gastrointestinal tract to isonicotinic acid. This metabolism did not occur following intravenous administration. Evidence is presented indicating that most of the ingested isonicotinuric acid escaped absorption from the small intestine and passed into the large intestine, where gastrointestinal bacteria hydrolyzed it to isonicotinic acid. The latter compound was subsequently absorbed into the systemic circulation, where some was reconjugated with glycine, forming the originally administered compound, isonicotinuric acid.
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This work was supported in part by National Science Foundation Grant GY 10651 and National Institutes of Health Training Grant GM 00728, U.S. Public Health Service, Bethesda, Maryland.
This paper was submitted to a Consulting Editor who served as the Journal Editor during its review process.
National Science Foundation Undergraduate Research Participant, Summer 1973, under Grant GY 10651.
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Boxenbaum, H.G., Jodhka, G.S., Ferguson, A.C. et al. The influence of bacterial gut hydrolysis on the fate of orally administered isonicotinuric acid in man. Journal of Pharmacokinetics and Biopharmaceutics 2, 211–237 (1974). https://doi.org/10.1007/BF01059763
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DOI: https://doi.org/10.1007/BF01059763