Abstract
The ability of Moloney murine leukemia virus to accelerate lymphomagenesis in Eμ-myc transgenic mice is frequently associated with proviral integration within a locus denotedbmi-1. This locus contains not only thebmi-1 gene implicated as a collaborator withmyc in lymphomagenesis but also just upstream an unknown gene denotedbup. The nucleotide sequence reported here forbup cDNA and flanking genomic sequences reveals that this widely expressed gene comprises at least 7 exons and potentially encodes a polypeptide of 195 amino acid residues. Computer searches with this polypeptide sequence revealed no close homolog in the databases, nor any conserved motifs, and it is unrelated to the product of themel-13 gene, which lies just upstream from thebmi-1 homologmel-18.
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Haupt, Y., Barri, G. & Adams, J.M. Nucleotide sequence ofbup, an upstream gene in thebmi-1 proviral insertion locus. Mol Biol Rep 17, 17–20 (1993). https://doi.org/10.1007/BF01006395
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DOI: https://doi.org/10.1007/BF01006395