Abstract
E-cadherin is a Ca2+-dependent cell adhesion molecule involved in cell-cell interaction. In its normal physiological function it plays an important role in embryonic development and tissue morphogenesis. Recent studies have shown that in cancer development E-cadherin can act as a suppressor of invasion. Indeed, in several kinds of carcinomas allelic loss of the E-cadherin/Uvomorulin locus and decreased E-cadherin expression have been described. The importance of E-cadherin in human cancer development may be substantiated by molecular analysis of the E-cadherin transcript. Therefore, we isolated and characterized the human E-cadherin cDNA. Comparison of the nucleotide and deduced amino acid sequences revealed that the human E-cadherin is highly homologous to the mouse E-cadherin (uvomorulin) and to other members of the cadherin family.
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Bussemakers, M.J.G., van Bokhoven, A., Mees, S.G.M. et al. Molecular cloning and characterization of the human E-cadherin cDNA. Mol Biol Rep 17, 123–128 (1993). https://doi.org/10.1007/BF00996219
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DOI: https://doi.org/10.1007/BF00996219