Abstract
Several neurochemical parameters were studied in brain regions of rats chronically treated with a high concentration of manganese chloride (20 mg MnCl2.4H2O per ml. of drinking water) throughout development until adulthood. Large increases in Mn accumulation were found in all brain regions (hypothalamus, +530%; striatum, +479%; other regions, +152 to +250%) of Mn-treated adult rats. In these animals, Ca levels were decreased (−20 to −46%) in cerebellum, hypothalamus, and cerebral cortex but were increased (+186%) in midbrain. Mg levels were decreased (−12 to −32%) in pons and medulla, midbrain, and cerebellum. Fe levels were increased (+95%) in striatum but were decreased (−28%) in cerebral cortex. Cu levels were increased (+43 to +100%) in pons and medulla and striatum but Zn levels were decreased (−30%) in pons and medulla. Na levels were increased (+22%) in striatum but those of K and Cl remained unchanged. Type A monoamine oxidase activities were decreased (−13 to −16%) in midbrain, striatum, and cerebral cortex, but type B monoamine oxidase activities decreased (−13%) only in hypothalamus. Acetylcholinesterase activities were increased (+20 to +22%) in striatum and cerebellum. The results are consistent with out hypothesis that chronic manganese encephalopathy not only affects brain metabolism of Mn but also that of other metals.
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We dedicate this paper to Professor Alan N. Davison. Professor Davison has conducted pioneering research in several important areas including: brain development and myelination, aging and Alzheimer's disease, and multiple sclerosis. He encouraged us to investigate the neurochemical mechanisms of neurotoxicity of metal ions, particularly in connection with neurological diseases. His encouragement and continued support facilitated the launching of our multidisciplinary research program in the long-term effects of manganese toxicity on brain development and aging.
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Lai, J.C.K., Chan, A.W.K., Leung, T.K.C. et al. Neurochemical changes in rats chronically treated with a high concentration of manganese chloride. Neurochem Res 17, 841–847 (1992). https://doi.org/10.1007/BF00993259
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DOI: https://doi.org/10.1007/BF00993259